-
1
-
-
0035874522
-
Human natural killer cells: A unique innate immunoregulatory role for the CD56(bright) subset
-
Cooper MA, Fehniger TA, Turner SC, et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood. 2001;97:3146-3151.
-
(2001)
Blood
, vol.97
, pp. 3146-3151
-
-
Cooper, M.A.1
Fehniger, T.A.2
Turner, S.C.3
-
2
-
-
33750121077
-
A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
-
Vosshenrich CA, Garcia-Ojeda ME, Samson-Villeger SI, et al. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol. 2006;7:1217-1224.
-
(2006)
Nat Immunol
, vol.7
, pp. 1217-1224
-
-
Vosshenrich, C.A.1
Garcia-Ojeda, M.E.2
Samson-Villeger, S.I.3
-
4
-
-
0036194976
-
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
-
Colucci F, Schweighoffer E, Tomasello E, et al. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol. 2002;3:288-294.
-
(2002)
Nat Immunol
, vol.3
, pp. 288-294
-
-
Colucci, F.1
Schweighoffer, E.2
Tomasello, E.3
-
5
-
-
0027939928
-
Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity
-
Bonnema JD, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J Exp Med. 1994;180:1427-1435.
-
(1994)
J Exp Med
, vol.180
, pp. 1427-1435
-
-
Bonnema, J.D.1
Karnitz, L.M.2
Schoon, R.A.3
Abraham, R.T.4
Leibson, P.J.5
-
6
-
-
0037600740
-
NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway
-
Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ. NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat Immunol. 2003;4:557-564.
-
(2003)
Nat Immunol
, vol.4
, pp. 557-564
-
-
Billadeau, D.D.1
Upshaw, J.L.2
Schoon, R.A.3
Dick, C.J.4
Leibson, P.J.5
-
7
-
-
0038549067
-
PI3K in lymphocyte development, differentiation and activation
-
Okkenhaug K, Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol. 2003;3:317-330.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 317-330
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
8
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu S. The role of PI3K in immune cells. Nat Immunol. 2003;4:313-319.
-
(2003)
Nat Immunol
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
9
-
-
1342292522
-
Phosphoinositide 3-kinase: Diverse roles in immune cell activation
-
Deane JA, Fruman DA. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol. 2004;22:563-598.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 563-598
-
-
Deane, J.A.1
Fruman, D.A.2
-
10
-
-
0034653608
-
The PI3K-PDK1 connection: More than just a road to PKB
-
Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J. 2000;346(pt 3):561-576.
-
(2000)
Biochem J
, vol.346
, Issue.PART 3
, pp. 561-576
-
-
Vanhaesebroeck, B.1
Alessi, D.R.2
-
11
-
-
18844449626
-
Vav-family proteins in T-cell signalling
-
Tybulewicz VL. Vav-family proteins in T-cell signalling. Curr Opin Immunol. 2005;17:267-274.
-
(2005)
Curr Opin Immunol
, vol.17
, pp. 267-274
-
-
Tybulewicz, V.L.1
-
12
-
-
0034092567
-
Tec family kinases in lymphocyte signaling and function
-
Schaeffer EM, Schwartzberg PL. Tec family kinases in lymphocyte signaling and function. Curr Opin Immunol. 2000;12:282-288.
-
(2000)
Curr Opin Immunol
, vol.12
, pp. 282-288
-
-
Schaeffer, E.M.1
Schwartzberg, P.L.2
-
14
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, Nussbaum RL. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem. 1999;274:10963-10968.
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Wynshaw-Boris, A.4
Nussbaum, R.L.5
-
15
-
-
0036185944
-
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
-
Bi L, Okabe I, Bernard DJ, Nussbaum RL. Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome. 2002;13:169-172.
-
(2002)
Mamm Genome
, vol.13
, pp. 169-172
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Nussbaum, R.L.4
-
16
-
-
0033555829
-
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
-
Suzuki H, Terauchi Y, Fujiwara M, et al. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science. 1999;283:390-392.
-
(1999)
Science
, vol.283
, pp. 390-392
-
-
Suzuki, H.1
Terauchi, Y.2
Fujiwara, M.3
-
17
-
-
0037119630
-
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton E, Bardi G, Bell SE, et al. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med. 2002;196:753-763.
-
(2002)
J Exp Med
, vol.196
, pp. 753-763
-
-
Clayton, E.1
Bardi, G.2
Bell, S.E.3
-
18
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
-
Jou ST, Carpino N, Takahashi Y, et al. Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol. 2002;22:8580-8591.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8580-8591
-
-
Jou, S.T.1
Carpino, N.2
Takahashi, Y.3
-
19
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
-
Okkenhaug K, Bilancio A, Farjot G, et al. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science. 2002;297:1031-1034.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
-
20
-
-
23844462453
-
-
Webb LM, Vigorito E, Wymann MP, Hirsch E, Turner M. Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol. 2005;175:2783-2787.
-
Webb LM, Vigorito E, Wymann MP, Hirsch E, Turner M. Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol. 2005;175:2783-2787.
-
-
-
-
21
-
-
33644765808
-
Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival
-
Swat W, Montgrain V, Doggett TA, et al. Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood. 2006;107:2415-2422.
-
(2006)
Blood
, vol.107
, pp. 2415-2422
-
-
Swat, W.1
Montgrain, V.2
Doggett, T.A.3
-
22
-
-
0028063854
-
Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction
-
Kanakaraj P, Duckworth B, Azzoni L, Kamoun M, Cantley LC, Perussia B. Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction. J Exp Med. 1994;179:551-558.
-
(1994)
J Exp Med
, vol.179
, pp. 551-558
-
-
Kanakaraj, P.1
Duckworth, B.2
Azzoni, L.3
Kamoun, M.4
Cantley, L.C.5
Perussia, B.6
-
23
-
-
0034330547
-
Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells
-
Jiang K, Zhong B, Gilvary DL, et al. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol. 2000;1:419-425.
-
(2000)
Nat Immunol
, vol.1
, pp. 419-425
-
-
Jiang, K.1
Zhong, B.2
Gilvary, D.L.3
-
24
-
-
4744369253
-
The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions
-
Zompi S, Gu H, Colucci F. The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions. J Leukoc Biol. 2004;76:896-903.
-
(2004)
J Leukoc Biol
, vol.76
, pp. 896-903
-
-
Zompi, S.1
Gu, H.2
Colucci, F.3
-
25
-
-
0038276047
-
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
-
Zompi S, Hamerman JA, Ogasawara K, et al. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol. 2003;4:565-572.
-
(2003)
Nat Immunol
, vol.4
, pp. 565-572
-
-
Zompi, S.1
Hamerman, J.A.2
Ogasawara, K.3
-
26
-
-
0036784633
-
Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells
-
Ogasawara K, Yoshinaga SK, Lanier LL. Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells. J Immunol. 2002;169:3676-3685.
-
(2002)
J Immunol
, vol.169
, pp. 3676-3685
-
-
Ogasawara, K.1
Yoshinaga, S.K.2
Lanier, L.L.3
-
27
-
-
25444436181
-
Src homology 2-containing inositol 5′-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12
-
Parihar R, Trotta R, Roda JM, et al. Src homology 2-containing inositol 5′-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12. Cancer Res. 2005;65:9099-9107.
-
(2005)
Cancer Res
, vol.65
, pp. 9099-9107
-
-
Parihar, R.1
Trotta, R.2
Roda, J.M.3
-
28
-
-
34247169493
-
p110delta is required for innate immunity to transplantable lymphomas
-
Saudemont A, Okkenhaug K, Colucci F. p110delta is required for innate immunity to transplantable lymphomas. Biochem Soc Trans. 2007;35:183-185.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 183-185
-
-
Saudemont, A.1
Okkenhaug, K.2
Colucci, F.3
-
29
-
-
23644458333
-
Licensing of natural killer cells by host major histocompatibility complex class I molecules
-
Kim S, Poursine-Laurent J, Truscott SM, et al. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature. 2005;436:709-713.
-
(2005)
Nature
, vol.436
, pp. 709-713
-
-
Kim, S.1
Poursine-Laurent, J.2
Truscott, S.M.3
-
30
-
-
24744435115
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps M, Ruckle T, Ji H, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005;11:936-943.
-
(2005)
Nat Med
, vol.11
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
-
31
-
-
33645827963
-
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
-
Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. Faseb J. 2006;20:455-465.
-
(2006)
Faseb J
, vol.20
, pp. 455-465
-
-
Lee, K.S.1
Lee, H.K.2
Hayflick, J.S.3
Lee, Y.C.4
Puri, K.D.5
-
32
-
-
23744492188
-
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
-
Condliffe AM, Davidson K, Anderson KE, et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood. 2005;106:1432-1440.
-
(2005)
Blood
, vol.106
, pp. 1432-1440
-
-
Condliffe, A.M.1
Davidson, K.2
Anderson, K.E.3
-
33
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, et al. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 2000;287:1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
-
34
-
-
14944355535
-
MHC class I molecules and KIRs in human history, health and survival
-
Parham P. MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol. 2005;5:201-214.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 201-214
-
-
Parham, P.1
-
35
-
-
23044436242
-
Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression
-
Stevenaert F, Van Beneden K, De Colvenaer V, et al. Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression. Blood. 2005;106:956-962.
-
(2005)
Blood
, vol.106
, pp. 956-962
-
-
Stevenaert, F.1
Van Beneden, K.2
De Colvenaer, V.3
-
36
-
-
0035908099
-
Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms
-
Colucci F, Rosmaraki E, Bregenholt S, et al. Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J Exp Med. 2001;193:1413-1424.
-
(2001)
J Exp Med
, vol.193
, pp. 1413-1424
-
-
Colucci, F.1
Rosmaraki, E.2
Bregenholt, S.3
-
37
-
-
18644385629
-
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
-
Huntington ND, Xu Y, Nutt SL, Tarlinton DM. A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J Exp Med. 2005;201:1421-1433.
-
(2005)
J Exp Med
, vol.201
, pp. 1421-1433
-
-
Huntington, N.D.1
Xu, Y.2
Nutt, S.L.3
Tarlinton, D.M.4
-
38
-
-
9644295710
-
-
Kovanen PE, Leonard WJ. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev. 2004;202:67-83.
-
Kovanen PE, Leonard WJ. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev. 2004;202:67-83.
-
-
-
-
39
-
-
10744230932
-
IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness
-
Sawitzki B, Kieselbach B, Fisser M, et al. IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness. J Am Soc Nephrol. 2004;15:695-703.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 695-703
-
-
Sawitzki, B.1
Kieselbach, B.2
Fisser, M.3
-
40
-
-
0036784641
-
IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway
-
Yoo JK, Cho JH, Lee SW, Sung YC. IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway. J Immunol. 2002;169:3637-3643.
-
(2002)
J Immunol
, vol.169
, pp. 3637-3643
-
-
Yoo, J.K.1
Cho, J.H.2
Lee, S.W.3
Sung, Y.C.4
-
41
-
-
0034068634
-
IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways
-
Athie MV, Flotow H, Hilyard KL, Cantrell DA. IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways. Eur J Immunol. 2000;30:1425-1434.
-
(2000)
Eur J Immunol
, vol.30
, pp. 1425-1434
-
-
Athie, M.V.1
Flotow, H.2
Hilyard, K.L.3
Cantrell, D.A.4
-
42
-
-
33749515632
-
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
-
Okkenhaug K, Patton DT, Bilancio A, Garcon F, Rowan WC, Vanhaesebroeck B. The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells. J Immunol. 2006;177:5122-5128.
-
(2006)
J Immunol
, vol.177
, pp. 5122-5128
-
-
Okkenhaug, K.1
Patton, D.T.2
Bilancio, A.3
Garcon, F.4
Rowan, W.C.5
Vanhaesebroeck, B.6
-
43
-
-
7244232917
-
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
-
Ali K, Bilancio A, Thomas M, et al. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature. 2004;431:1007-1011.
-
(2004)
Nature
, vol.431
, pp. 1007-1011
-
-
Ali, K.1
Bilancio, A.2
Thomas, M.3
-
44
-
-
3042707308
-
Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells
-
Moody JL, Jirik FR. Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells. Immunology. 2004;112:404-412.
-
(2004)
Immunology
, vol.112
, pp. 404-412
-
-
Moody, J.L.1
Jirik, F.R.2
|