Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

Science

Volumn 325, Issue 5945, 2009, Pages 1261-1265

  Fine, Barry ^a   Hodakoski, Cindy ^a   Koujak, Susan ^a   Su, Tao ^a,b   Saal, Lao H ^a   Maurer, Matthew ^a,b   Hopkins, Benjamin ^a   Keniry, Megan ^a   Sulis, Maria Luisa ^a,b   Mense, Sarah ^a   Hibshoosh, Hanina ^a,b   Parsons, Ramon ^a,b  

^a Howard Hughes Medical Institute   (United States)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE RAC EXCHANGER 2A; PROTEIN KINASE B; PROTEIN P110; RAC PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ABUNDANCE INDEX; ANTAGONISM; CANCER; CHROMOSOME; DISEASE CONTROL; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH RATE; HOMOLOGY; LIPID; MUTATION; RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GENETICS; CANCER GROWTH; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 69949170092     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1173569     Document Type: Article

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