Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

Mammalian Genome

Volumn 13, Issue 3, 2002, Pages 169-172

  Bi, Lei ^a   Okabe, Ichiro ^a   Bernard, David J ^a   Nussbaum, Robert L ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; EMBRYO; EMBRYO DEATH; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SUBUNIT; GENE ISOLATION; LETHALITY; MOUSE; NONHUMAN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASE SEQUENCE; FETAL DEATH; MICE; PROTEIN SUBUNITS; SEQUENCE DELETION;

EID: 0036185944     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00335-001-2123-x     Document Type: Article

References (22)

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2. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
3. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
4. Phosphatidylinositol-3-OH kinases are Rab5 effectors
5. Fibroblast growth factor receptor 3 is a negative regulator of bone growth
6. Phosphoinositide kinases
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8. Ethanol precipitation of DNA with linear polyacrylamide as carrier
9. Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
10. The PI 3-kinase isoforms pll0(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling
11. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
12. Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors
13. Nondisjunction rates and abnormal development in a mouse cross between heterozygotes carrying a (7,18) robertsonian translocation
14. A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
15. Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
16. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
17. Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene
18. P110delta, a novel phosphoinositide 3-kinase in leukocytes
19. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
20. Synthesis and function of 3-phosphorylated inositol lipids
21. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
22. Structure and function of phosphoinositide 3-kinases