Essential immunoregulatory role for BCAP in B cell development and function

Journal of Experimental Medicine

Volumn 195, Issue 5, 2002, Pages 535-545

  Yamazaki, Tetsuo ^a   Takeda, Kiyoshi ^c   Gotoh, Kumiko ^a,b   Takeshima, Hiroshi ^d   Akira, Shizuo ^c   Kurosaki, Tomohiro ^a,b,e  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d KURUME UNIVERSITY   (Japan)

^e Department of Molecular Genetics   (Japan)

Author keywords

Antigen receptor; Calcium; Knockout; Mice; Phospholipase C

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CALCIUM MOBILIZATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CROSS LINKING; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; CALCIUM; CARRIER PROTEINS; ISOENZYMES; MICE; MICE, KNOCKOUT; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; RECEPTORS, ANTIGEN, B-CELL;

EID: 0037018096     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011751     Document Type: Article

References (62)

1. Antibody regulation of B cell development
2. B cell development pathways
3. B cell development: Signal transduction by antigen receptors and their surrogates
4. Clonal selection and learning in the antibody system
5. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
6. Syk tyrosine kinase required for mouse viability and B-cell development
7. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
8. The complexity of signaling pathways activated by the BCR
9. Initiation and processing of signals from the B cell antigen receptor
10. Antigen receptor signaling: Integration of protein tyrosine kinase functions
11. Genetic analysis of B cell antigen receptor signaling
12. Signal transduction from the B cell antigen-receptor
13. Adapters in lymphocyte signalling
14. Regulation of B cell function by linker proteins
15. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
16. Requirement for B cell linker protein (BLNK) in B cell development
17. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
18. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
19. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
20. Essential role of Stat6 in IL-4 signalling
21. Cutting edge: Essential role of phospholipase C-γ2 in B cell development and function
22. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
23. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
24. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
25. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
26. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
27. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
28. hi and exhibit unique signaling characteristics
29. hi splenic B cells are immature developmental intermediates in the production of long-lived marrow-derived B cells
30. Phospholipase C-γ2 is essential in the functions of B cell and several Fc receptors
31. BLNK: Connecting Syk and Btk to calcium signals
32. SHIP modulates immune receptor responses by regulating membrane association of Btk
33. Phosphatidylinositol-3,4,5-trisphosphate (Pt-dIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
34. Activation of phospholipase C-γ by PI 3-kinase-induced PH domain-mediated membrane targeting
35. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs
36. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow
37. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
38. Development and function of B-1 cells
39. B1 cells: Similarities and differences with other B cell subsets
40. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
41. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
42. Impaired expansion of mouse B cell progenitors lacking Btk
43. Defective B cell development and function in Btk-deficient mice
44. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation
45. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
46. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
47. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
48. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
49. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
50. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase
51. The Gab1 docking protein links the B cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
52. 2+ flux
53. BLNK required for coupling Syk to PLC-γ2 and Rac1-JNK in B cells
54. Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-γ on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region
55. Association of Grb2, Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
56. Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
57. Vav and the B cell signalosome
58. Xid-like phenotypes: A B cell signalosome takes shape
59. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
60. 2+ response amplitude and duration
61. Calcium oscillations increase the efficiency and specificity of gene expression
62. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection