-
1
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol 11:373-384.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
2
-
-
67649422321
-
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
-
O'Neill LA, Bryant CE, Doyle SL (2009) Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 61:177-197.
-
(2009)
Pharmacol Rev
, vol.61
, pp. 177-197
-
-
O'Neill, L.A.1
Bryant, C.E.2
Doyle, S.L.3
-
3
-
-
79954577277
-
TLR-signaling networks: An integration of adaptor molecules, kinases, and cross-talk
-
Brown J, Wang H, Hajishengallis GN, Martin M (2011) TLR-signaling networks: An integration of adaptor molecules, kinases, and cross-talk. J Dent Res 90:417-427.
-
(2011)
J Dent Res
, vol.90
, pp. 417-427
-
-
Brown, J.1
Wang, H.2
Hajishengallis, G.N.3
Martin, M.4
-
4
-
-
0037199972
-
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
-
DOI 10.1074/jbc.M203298200
-
Guha M, Mackman N (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 277:32124-32132. (Pubitemid 34969025)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.35
, pp. 32124-32132
-
-
Guha, M.1
Mackman, N.2
-
5
-
-
33745868678
-
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
-
DOI 10.1074/jbc.M513861200
-
Rhee SH, Kim H, Moyer MP, Pothoulakis C (2006) Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem 281:18560-18568. (Pubitemid 44035515)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.27
, pp. 18560-18568
-
-
Sang, H.R.1
Kim, H.2
Moyer, M.P.3
Pothoulakis, C.4
-
6
-
-
0035813157
-
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
-
Re F, Strominger JL (2001) Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 276:37692-37699.
-
(2001)
J Biol Chem
, vol.276
, pp. 37692-37699
-
-
Re, F.1
Strominger, J.L.2
-
7
-
-
0037031924
-
Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
-
DOI 10.1074/jbc.M203218200
-
Monick MM, et al. (2002) Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem 277:32992-33000. (Pubitemid 34984814)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.36
, pp. 32992-33000
-
-
Monick, M.M.1
Robeff, P.K.2
Butler, N.S.3
Flaherty, D.M.4
Brent, C.A.5
Peterson, M.W.6
Hunninghake, G.W.7
-
8
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T, et al. (2002) PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 3:875-881.
-
(2002)
Nat Immunol
, vol.3
, pp. 875-881
-
-
Fukao, T.1
-
9
-
-
47049086825
-
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages
-
Kuroda S, et al. (2008) Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 38:1331-1340.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1331-1340
-
-
Kuroda, S.1
-
10
-
-
0038446051
-
Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
-
Martin M, et al. (2003) Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol 171:717-725. (Pubitemid 36871381)
-
(2003)
Journal of Immunology
, vol.171
, Issue.2
, pp. 717-725
-
-
Martin, M.1
Schifferle, R.E.2
Cuesta, N.3
Vogel, S.N.4
Katz, J.5
Michalek, S.M.6
-
11
-
-
78649615595
-
SHIP negatively regulates Flt3L-derived dendritic cell generation and positively regulates MyD88-independent TLR-induced maturation
-
Antignano F, Ibaraki M, Ruschmann J, Jagdeo J, Krystal G (2010) SHIP negatively regulates Flt3L-derived dendritic cell generation and positively regulates MyD88-independent TLR-induced maturation. J Leukoc Biol 88:925-935.
-
(2010)
J Leukoc Biol
, vol.88
, pp. 925-935
-
-
Antignano, F.1
Ibaraki, M.2
Ruschmann, J.3
Jagdeo, J.4
Krystal, G.5
-
12
-
-
50949130076
-
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
-
Ohtani M, et al. (2008) Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112:635-643.
-
(2008)
Blood
, vol.112
, pp. 635-643
-
-
Ohtani, M.1
-
13
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
DOI 10.1038/nrg1879, PII NRG1879
-
Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7:606-619. (Pubitemid 44100518)
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
14
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
15
-
-
0034507903
-
BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
-
DOI 10.1016/S1074-7613(00)00079-0
-
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (2000) BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13:817-827. (Pubitemid 32041804)
-
(2000)
Immunity
, vol.13
, Issue.6
, pp. 817-827
-
-
Okada, T.1
Maeda, A.2
Iwamatsu, A.3
Gotoh, K.4
Kurosaki, T.5
-
16
-
-
47249118882
-
Enhanced NK-cell development and function in BCAP-deficient mice
-
MacFarlane AW, 4th, et al. (2008) Enhanced NK-cell development and function in BCAP-deficient mice. Blood 112:131-140.
-
(2008)
Blood
, vol.112
, pp. 131-140
-
-
MacFarlane IV, A.W.1
-
17
-
-
77649184739
-
The regulation of IL-10 production by immune cells
-
Saraiva M, O'Garra A (2010) The regulation of IL-10 production by immune cells. Nat Rev Immunol 10:170-181.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 170-181
-
-
Saraiva, M.1
O'Garra, A.2
-
18
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
DOI 10.1126/science.275.5300.665
-
Franke TF, Kaplan DR, Cantley LC, Toker A (1997) Direct regulation of the Akt protooncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275:665-668. (Pubitemid 27061333)
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
19
-
-
22544445221
-
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4
-
DOI 10.1002/eji.200425801
-
Aksoy E, et al. (2005) Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4. Eur J Immunol 35:2200-2209. (Pubitemid 41015059)
-
(2005)
European Journal of Immunology
, vol.35
, Issue.7
, pp. 2200-2209
-
-
Aksoy, E.1
Berghe, W.V.2
Detienne, S.3
Amraoui, Z.4
Fitzgerald, K.A.5
Haegemann, G.6
Goldman, M.7
Willems, F.8
-
20
-
-
33745013651
-
Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
-
Yang CS, et al. (2006) Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Cell Microbiol 8:1158-1171.
-
(2006)
Cell Microbiol
, vol.8
, pp. 1158-1171
-
-
Yang, C.S.1
-
21
-
-
33645801404
-
Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)- benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: Negative regulation of nuclear factor-kappaB by phosphoinositide 3-kinase
-
Hazeki K, et al. (2006) Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: Negative regulation of nuclear factor-kappaB by phosphoinositide 3-kinase. Mol Pharmacol 69:1717-1724.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1717-1724
-
-
Hazeki, K.1
-
22
-
-
0037079737
-
Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement
-
DOI 10.1182/blood.V99.2.584
-
Inabe K, Kurosaki T (2002) Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement. Blood 99:584-589. (Pubitemid 34533096)
-
(2002)
Blood
, vol.99
, Issue.2
, pp. 584-589
-
-
Inabe, K.1
Kurosaki, T.2
-
23
-
-
38949164409
-
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
-
DOI 10.1182/blood-2007-08-109769
-
Aiba Y, Kameyama M, Yamazaki T, Tedder TF, Kurosaki T (2008) Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 111:1497-1503. (Pubitemid 351213438)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1497-1503
-
-
Aiba, Y.1
Kameyama, M.2
Yamazaki, T.3
Tedder, T.F.4
Kurosaki, T.5
-
24
-
-
0037629646
-
PI3K and negative regulation of TLR signaling
-
DOI 10.1016/S1471-4906(03)00139-X
-
Fukao T, Koyasu S (2003) PI3K and negative regulation of TLR signaling. Trends Immunol 24:358-363. (Pubitemid 36830961)
-
(2003)
Trends in Immunology
, vol.24
, Issue.7
, pp. 358-363
-
-
Fukao, T.1
Koyasu, S.2
-
25
-
-
0037018096
-
Essential immunoregulatory role for BCAP in B cell development and function
-
DOI 10.1084/jem.20011751
-
Yamazaki T, et al. (2002) Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med 195:535-545. (Pubitemid 34461499)
-
(2002)
Journal of Experimental Medicine
, vol.195
, Issue.5
, pp. 535-545
-
-
Yamazaki, T.1
Takeda, K.2
Gotoh, K.3
Takeshima, H.4
Akira, S.5
Kurosaki, T.6
-
26
-
-
0034577944
-
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
-
Arbibe L, et al. (2000) Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol 1:533-540.
-
(2000)
Nat Immunol
, vol.1
, pp. 533-540
-
-
Arbibe, L.1
-
27
-
-
0036231179
-
Syk is required for integrin signaling in neutrophils
-
DOI 10.1016/S1074-7613(02)00303-5
-
Mócsai A, Zhou M, Meng F, Tybulewicz VL, Lowell CA (2002) Syk is required for integrin signaling in neutrophils. Immunity 16:547-558. (Pubitemid 34442579)
-
(2002)
Immunity
, vol.16
, Issue.4
, pp. 547-558
-
-
Mocsai, A.1
Zhou, M.2
Meng, F.3
Tybulewicz, V.L.4
Lowell, C.A.5
-
28
-
-
20644443886
-
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
-
DOI 10.1038/ni1204
-
Hamerman JA, Tchao NK, Lowell CA, Lanier LL (2005) Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 6:579-586. (Pubitemid 41710728)
-
(2005)
Nature Immunology
, vol.6
, Issue.6
, pp. 579-586
-
-
Hamerman, J.A.1
Tchao, N.K.2
Lowell, C.A.3
Lanier, L.L.4
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