Melt extrusion with poorly soluble drugs

International Journal of Pharmaceutics

Volumn 453, Issue 1, 2013, Pages 233-252

  Shah, Sejal ^a   Maddineni, Sindhuri ^a   Lu, Jiannan ^a   Repka, Michael A ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Amorphous system; Dissolution rate enhancement; Melt extrusion; Poorly water soluble drugs; Solid dispersion; Solid solution; Thermoplastic polymers

Indexed keywords

CELLULOSE; CYCLODEXTRIN; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; MACROGOL; MACROGOL DERIVATIVE; POLOXAMER; POLYMETHACRYLIC ACID DERIVATIVE; POVIDONE;

AREA UNDER THE CURVE; CRYSTALLIZATION; DISPERSION; DISSOLUTION; DOWNSTREAM PROCESSING; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STABILITY; EVAPORATION; GLASS TRANSITION TEMPERATURE; GOOD MANUFACTURING PRACTICE; HIGH TEMPERATURE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MELT EXTRUSION; MELTING POINT; MISCIBILITY; MOLECULAR WEIGHT; NONHUMAN; PHASE SEPARATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SCALE UP; SHEAR STRESS; SOLID STATE; SOLUBILIZATION; SPHERONIZATION; SPRAY DRYING; SUSTAINED DRUG RELEASE; TABLET FORMULATION; THERMOSTABILITY;

EID: 84884140474     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.11.001     Document Type: Review

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