Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion

Pharmaceutical Research

Volumn 29, Issue 3, 2012, Pages 806-817

  Liu, Xu ^a   Lu, Ming ^a   Guo, Zhefei ^a   Huang, Lin ^a   Feng, Xin ^a   Wu, Chuanbin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Carbamazepine; Cocrystal; Hot melt extrusion; Solid dispersion; Thermal degradation

Indexed keywords

CARBAMAZEPINE; NICOTINAMIDE; POLYMER; ANALGESIC AGENT; VITAMIN B COMPLEX;

ANALYTIC METHOD; ARTICLE; COCRYSTAL TECHNIQUE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STABILITY; HEAT SENSITIVITY; HOT MELT EXTRUSION; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; MELTING POINT; MOLECULAR STABILITY; POWDER DIFFRACTION; PRIORITY JOURNAL; THERMOGRAVIMETRY; THERMOSTABILITY; X RAY DIFFRACTION; CHEMISTRY; FREEZING; METHODOLOGY; SOLUBILITY;

ANALGESICS, NON-NARCOTIC; CALORIMETRY, DIFFERENTIAL SCANNING; CARBAMAZEPINE; CRYSTALLIZATION; DRUG STABILITY; FREEZING; NIACINAMIDE; POLYMERS; POWDER DIFFRACTION; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VITAMIN B COMPLEX; X-RAY DIFFRACTION;

EID: 84862304361     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0605-4     Document Type: Article

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