Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis

International Journal of Pharmaceutics

Volumn 226, Issue 1-2, 2001, Pages 147-161

  Forster, A ^a,b,c   Hempenstall, J ^b   Tucker, I ^a   Rades, T ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Cell Biology Unit   (United Kingdom)

Author keywords

Drug excipient interactions; Indomethacin; Lacidipine; Melt extrusion; Solubility parameters; Thermal analysis

Indexed keywords

CITRIC ACID; EXCIPIENT; GLASS; GLUCOSE; INDOMETACIN; LACIDIPINE; LACTOSE; MACROGOL; MANNITOL; POVIDONE; SUCROSE; VINYL ACETATE;

ANALYTIC METHOD; ARTICLE; CALCULATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; MISCIBILITY; PRIORITY JOURNAL; TEMPERATURE; THERMAL ANALYSIS;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DIHYDROPYRIDINES; EXCIPIENTS; INDOMETHACIN; SOLUBILITY;

EID: 0035845751     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00801-8     Document Type: Article

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