Prediction of the thermal phase diagram of amorphous solid dispersions by flory-huggins theory

Journal of Pharmaceutical Sciences

Volumn 100, Issue 8, 2011, Pages 3196-3207

  Zhao, Yinyan ^a   Inbar, Petra ^a   Chokshi, Hitesh P ^a   Malick, A Wasseem ^a   Choi, Duk Soon ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Amorphous; Formulation; Interaction; Miscibility; Phase diagram; Physical stability; Solid dispersion

Indexed keywords

COPOLYMER; INDOMETACIN; POLYMER; POVIDONE; VINYL ACETATE;

ARTICLE; CHEMICAL PARAMETERS; DISPERSION; DRUG SOLUBILITY; FLORY HUGGINS THEORY; HILDEBRAND AND SCOTT SOLUBILITY; MELTING POINT; MISCIBILITY; PREDICTION; SOLID; TEMPERATURE; THEORY; THERMODYNAMICS;

EID: 79958842268     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22541     Document Type: Article

References (28)

1. Marsac PJ, Shamblin SL, Taylor LS. 2006. Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm Res 23:2417-2426.
2. Tao J, Sun Y, Zhang GGZ, Yu L. 2009. Solubility of small-molecule crystals in polymers: d-Mannitol in PVP, indomethacin in PVP/VA, and nifedipine in PVP/VA. Pharm Res 26:855-864.
3. Friesen DT, Shanker R, Crew M, Smithey DT, Curatolo WJ, Nightingale JAS. 2008. Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: An overview. Mol Pharm 5:1003-1019.
4. Billmeyer FW, Jr. 1984. Textbook of polymer science. 3rd ed. New York: John Wiley & Sons.
5. Flory PJ. 1953. Principles of polymer chemistry. Ithaca, New York: Cornell University Press.
6. Rubinstein M, Colby RH. 2003. Polymer physics (chemistry). Chap. 4, New York: Oxford University Press.
7. Nishi T, Wang TT. 1975. Melting point depression and kinetic effects of cooling on crystallization in poly(vinylidene fluride)-poly (methyl methacrylate) mixtures. Macromolecules 8:909-915.
8. Hildebrand J, Scott R. 1950. Solubility of non-electrolytes. 3rd ed. New York: Reinhold.
9. Hoy KL. 1985. The Hoy tables of solubility parameters. South Charleston, WV: Union Carbide Corporation.
10. Hoftyzer PJ, Van Krevelen DW. 1976. Properties of polymers. 2nd ed. Chapter 7, New York: Elsevier Scientific Publication.
11. Small PA. 1953. Some factors affecting the solubility of polymers. J Appl Chem 3:71-80.
12. g, molar cohesion and polymer structure. J Appl Polym Sci 5:318-321.
13. Fedors RF. 1974. A method for estimating both the solubility parameters and molar volumes of liquids. Polym Eng Sci 14:147-154.
14. Van Krevelen DW, Te Nijenhuis K. 2009. Properties of polymers. 4th ed. Chapter 7, Oxford, UK: Elsevier Scientific Publication.
15. Scott RL. 1949. The thermodynamics of high polymer solutions. V. Phase equilibria in the ternary system: Polymer 1-polymer 2-solvent. J Chem Phys 17:279-284.
16. Marsac PJ, Li T, Taylor LS. 2009. Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters. Pharm Res 26:139-151.
17. Sun Y, Tao J, Zhang GGZ, Yu L. 2010. Solubility of crystalline drugs in polymers: An improved analytical method and comparison of solubilities of indomethacin and nifedipine in PVP, PVP/VA, and PVAc. J Pharm Sci in press.
18. Barton AFM. 1975. Solubility parameters. Chem Rev 75: 731-753.
19. Coleman MM, Serman CJ, Bhagwagar DE, Painter PC. 1990. A practical guide to polymer miscibility. Polymer 31:1187-1203.
20. Yoshioka M, Hancock BC, Zografi G. 1994. Crystallization of indomethacin from the amorphous state below and above its glass transition temperature. J Pharm Sci 83:1700-1705.
21. Andronis V, Zografi G. 2000. Crystal nucleation and growth of indomethacin polymorphs from the amorphous state. J Non-Cryst Solids 271:236-248.
22. Pan X, Julian T, Augsburger L. 2006. Quantitative measurement of indomethacin crystallinity in indomethacin-silica gel binary system using different scanning calorimetry and X-ray powder diffractometry. AAPS PharmSciTech 7:E1-E7.
23. Yoshioka M, Hancock BC, Zografi G. 1995. Inhibition of indomethacin crystallization in poly (vinylpyrrolidone) coprecipitates. J Pharm Sci 84: 983-986.
24. Wang X, de Armas HN, Blaton N, Michoel A, den Mooter GV. 2007. Phase characterization of indomethacin in binary solid dispersions with PVP VA64 or Myrj 52. Int J Pharm 345:95-100.
25. Lu X, Weiss RA. 1992. Relationship between the glass transition temperature and the interaction parameter of miscible binary polymer blends. Macromolecules 25:3242-3246.
26. Russell TP, Hjelm RP Jr, Seeger PA. 1980. Temperature dependence of the interaction parameters of polystyrene and poly (methyl methacrylate). Macromolecules 13:890-893.
27. Yuan S-L, Xu G-Y, Cai Z-T, Jian Y-S. 2003. Molecular simulation studies on the interaction between different polymers in aqueous solution. Colloid Polym Sci 281:66-72.
28. Pajula K, Taskinen M, Lehto VP, Ketolainen J, Korhonen O. 2010. Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram. Mol Pharmaceutics 7:795-804.