The potential of small-scale fusion experiments and the Gordon-Taylor equation to predict the suitability of drug/polymer blends for melt extrusion

Drug Development and Industrial Pharmacy

Volumn 27, Issue 6, 2001, Pages 549-560

  Forster, A ^a   Hempenstall, J ^b   Tucker, I ^a   Rades, T ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Drug polymer blends; Gordon Taylor equation; Melt extrusion; Solid dispersions

Indexed keywords

GLASS; INDOMETACIN; LACIDIPINE; NIFEDIPINE; PIROXICAM; POLYMER; POVIDONE; TOLBUTAMIDE;

ARTICLE; CALCULATION; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; EQUIPMENT; MELTING POINT; STOICHIOMETRY; X RAY POWDER DIFFRACTION;

ALGORITHMS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DRUG COMPOUNDING; DRUG STABILITY; ELECTROPHORESIS, CAPILLARY; HUMIDITY; MICROSCOPY, ELECTRON, SCANNING; PHARMACEUTIC AIDS; PHARMACEUTICAL PREPARATIONS; POLYMERS; POVIDONE; SOLUBILITY;

EID: 0034868680     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100105180     Document Type: Article

References (24)

1. Feste loesungen durch schmelzextrusion, ein integriertes herstellungskonzept
2. Solid dispersions by an integrated melt extrusion system
3. Polymer/drug-melt extrusion: Therapeutic and technological appeal
4. The current status of solid dispersions
5. The use of solubility parameters in pharmaceutical dosage form design
6. Solid dispersions of poorly water-soluble drugs: Early promises, subsequent problems and recent breakthroughs
7. Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates
8. Modulated differential scanning calorimetry: 4. Miscibility and glass transition behaviour in poly(methylmethacrylate) and poly(epichlorohydrin) blends
9. Glass fragility and the stability of pharmaceutical preparations - Excipient selection
10. Glassy state of pharmaceuticals. IV. Studies on pharmaceuticals by thermomechanical analysis
11. Mechanisms of dissolution of fast release solid dispersions
12. The effects of adsorbed water on the properties of amorphous mixtures containing sucrose
13. Stabilization of the amorphous state of indomethacin by solid dispersion in polyvinylpyrrolidone
14. Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions
15. Highly efficient and selective separations of a wider range of anayltes obtained by an optimized microemulsion electrokinetic chromatography method
16. Application of microemulsion electrokinetic chromatography to the analysis of a wide range of pharmaceuticals and excipients
17. Investigation of piroxicam polymorphism
18. Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates
19. Characterization of tolbutamide polymorphs (Burges Form II and IV) and polymorphic transition behaviour
20. Phase behaviour of binary and ternary amorphous mixtures containing indomethacin, citric acid and PVP
21. Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallisation
22. Effect of high molecular mobility of poly(vinylalcohol) on protein stability of lyophilized gamma-globulin formulations
23. Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures
24. Nucleation phenomena in amorphous sucrose systems