Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization

Pharmaceutical Research

Volumn 16, Issue 11, 1999, Pages 1722-1728

  Matsumoto, Takahiro ^a,b   Zografi, George ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Crystallization; Glass transition; Indomethacin; Molecular dispersion; Molecular mobility; Polymer

Indexed keywords

INDOMETACIN; POVIDONE; POVIDONE DERIVATIVE; VINYL ACETATE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; ENTHALPY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; PRIORITY JOURNAL; SOLID STATE;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DENSITOMETRY; INDOMETHACIN; MOLECULAR WEIGHT; POVIDONE; PYRROLIDINES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; TIME FACTORS; VINYL COMPOUNDS; X-RAY DIFFRACTION;

EID: 0032756138     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018906132279     Document Type: Article

References (29)

1. 1. K. Yamamoto, M. Nakano, T. Arita, Y. Takayama, and Y. Nakai. Dissolution behavior and bioavailability of phenytoin from a ground mixture with microcrystalline cellulose. J. Pharm. Sci. 65:1484-1488 (1970).
2. 2. W. L. Chiou and S. T. Reigelman. Oral absorption of griseofulvin in dogs. Increased absorption via solid dispersion in polyethylene glycol 6000. J. Pharm. Sci. 59:937-942 (1970).
3. 3. H. Imaizumi, N. Nambu, and T. Nagai. Stability and several physical properties of amorphous and crystalline forms of indomethacin. Chem. Pharm. Bull. 28:2565-2569 (1980).
4. 4. M. Otsuka and N. Kaneniwa. A kinetic study of the crystallization process of noncrystalline indomethacin under isothermal conditions. Chem. Pharm. Bull. 36:4026-4032 (1988).
5. 5. V. Andronis, M. Yoshioka, and G. Zografi. Effect of sorbed water on the crystallization of indomethacin from the amorphous state. J. Pharm. Sci. 86:346-351 (1997).
6. 6. W. L. Chiou and S. T. Reigelman. Pharmaceutical application of solid dispersion systems. J. Pharm. Sci. 60:1281-1302 (1971).
7. 7. A. P. Simonelli, S. C. Mehta, and W. I. Higuchi. Dissolution rates of higher energy sulfathiazole-povidone coprecipitates 2: Characterization of form of drug controlling its dissolution rate via solubility studies. J. Pharm. Sci. 65:355-361 (1976).
8. 8. H. Imaizumi, N. Nambu, and T. Nagai. Stabilization of amorphous state of indomethacin by solid dispersion in polyvinylpyrrolidone. Chem. Pharm. Bull. 31:2510-2512 (1983).
9. 9. H. Sekizaki, K. Danjo, H. Eguchi, Y. Yonezawa, H. Sunada, and A. Otsuka. Solid-state interaction of ibuprofen with polyvinylpyrrolidone. Chem. Pharm. Bull. 43:988-993 (1995).
10. 10. M. Yoshioka, B. C. Hancock, and G. Zografi. Crystallization of indomethacin from the amorphous state below and above its glass transition temperature. J. Pharm. Sci. 83:1700-1705 (1994).
11. 11. V. Andronis and G. Zografi. The molecular mobility of supercooled amorphous indomethacin as a function of temperature and relative humidity. Pharm. Res. 15:835-842 (1998).
12. 12. C. A. Okasanen and G. Zografi. The relationship between the glass transition temperature and water vapor absorption by poly(-vinylpyrrolidone). Pharm. Res. 7:654-657 (1990).
13. 13. C. A. Okasanen and G. Zografi. Molecular mobility in mixtures of absorbed water and solid poly(vinylpyrrolidone). Pharm. Res. 10:791-799 (1993).
14. 14. M. Yoshioka, B. C. Hancock, and G. Zografi. Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates. J. Pharm. Sci. 84:983-986 (1995).
15. 15. L. S. Taylor and G. Zografi. Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. Pharm. Res. 14:1691-1698 (1997).
16. 16. V. Andronis. Crystallization of amorphous indomethacin. Ph. D. Thesis. University of Wisconsin-Madison (1997).
17. 17. V. Buhler. Kollidone, Second ed., BASF Akiengesellschaft, Ludwigshafen, 1993.
18. 18. B. C. Hancock, S. L. Shamblin, and G. Zografi. The molecular mobility of amorphous pharmaceutical solids below their glass transition temperature. Pharm. Res. 12:799-806 (1995).
19. 19. S. L. Shamblin and G. Zografi. Enthalpy relaxation in binary amorphous mixtures containing sucrose. Pharm. Res. 15:1828-1834 (1998).
20. 20. B. C. Hancock, C. R. Dalton, M. J. Pikal, and S. L. Shamblin. A pragmatic test of a simple calorimetric method for determining the fragility of some amorphous pharmaceutical materials. Pharm. Res. 15:762-767 (1998).
21. 21. R. Simha and R. F. Boyer. On a general relation involving the glass temperature and coefficients of expansion of polymers. J. Chem. Phys. 37:1003-1007 (1962).
22. 22. M. Gordon and J. S. Taylor. Ideal copolymers and the second-order transition of synthetic rubbers I. Non-crystalline co-polymers. J. Appl. Chem. 2:493-500 (1952).
23. 23. P. R. Couchman and F. E. Karasz. A classical thermodynamic discussion on the effect of composition on glass-transition temperatures. Macromol. 11:117-119 (1978).
24. 24. S. L. Shamblin, L. S. Taylor, and G. Zografi. Mixing behavior of colyophilized binary systems. J. Pharm. Sci. 87:694-701 (1998).
25. 25. J. Cowie and R. Ferguson. Physical aging studies in poly(vinylmethyl ether). I. Enthalpy relaxation as a function of aging temperature. Macromol. 22:2307-2312 (1989).
26. 26. I. M. Hodge. Enthalpy relaxation and recovery in amorphous materials. J. Non-Cryst. Solids 169:211-266 (1994).
27. 27. A. Brunacci, J. Cowie, R. Ferguson, and I. McEwen. Enthalpy relaxation in glassy polystyrenes: I. Polymer 38:865-870 (1997).
28. 28. M. D. Ediger, C. A. Angell, and S. R. Nagel. Supercooled liquids and glasses. J. Phys. Chem. 100:13200-13212 (1996).
29. 29. T. J. Kistenmacher and R. E. March. Crystal and molecular structure of an antiinflammatory agent. Indomethacin. J. Amer. Chem. Soc. 94:1340-1345 (1972).