Compositional analysis of low quantities of phase separation in hot-melt-extruded solid dispersions: A combined atomic force microscopy, photothermal fourier-transform infrared microspectroscopy, and localised thermal analysis approach

Pharmaceutical Research

Volumn 28, Issue 9, 2011, Pages 2311-2326

  Qi, Sheng ^a   Belton, Peter ^a   Nollenberger, Kathrin ^b   Gryczke, Andreas ^b   Craig, Duncan Q M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b Evonik Rohm GmbH   (Germany)

Author keywords

Hot melt extruded solid dispersion; Phase separation; Photothermal FTIR microspectroscopy; Pulsed force mode atomic force microscopy; Supersaturation

Indexed keywords

EUDRAGIT; FELODIPINE;

AGING; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISPERSION; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; HIGH TEMPERATURE PROCEDURES; INFRARED SPECTROSCOPY; NANOANALYSIS; PHASE SEPARATION; PRIORITY JOURNAL; QUANTITATIVE STUDY; SOLID DISPERSION; THERMAL ANALYSIS;

CRYSTALLIZATION; DIFFERENTIAL THERMAL ANALYSIS; FELODIPINE; HOT TEMPERATURE; MICROSCOPY, ATOMIC FORCE; PHASE TRANSITION; POLYMETHACRYLIC ACIDS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 80054726007     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0461-2     Document Type: Article

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