Influence of formulation and process parameters on the release characteristics of ethylcellulose sustained-release mini-matrices produced by hot-melt extrusion

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 1, 2008, Pages 312-319

  Verhoeven, E ^a   De Beer, T R M ^a   Van den Mooter, G ^b   Remon, J P ^a   Vervaet, C ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Hot melt extrusion; Matrix system; Multiple unit dosage form; Sustained release; Xanthan gum

Indexed keywords

ETHYL CELLULOSE; METOPROLOL TARTRATE; SEBACIC ACID DIBUTYL ESTER; UNCLASSIFIED DRUG; XANTHAN; XANTURAL;

ARTICLE; CONCENTRATION (PARAMETERS); DRUG DOSAGE FORM; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; HOT MELT EXTRUSION; POWDER; QUALITATIVE ANALYSIS; RAMAN SPECTROMETRY; SUSTAINED DRUG RELEASE;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; PHARMACEUTICAL PREPARATIONS; PLASTICIZERS; POLYMERS; POLYSACCHARIDES, BACTERIAL; POWDERS; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 41549109232     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.10.007     Document Type: Article

References (23)

1. W. Mueller, R. Spengler, S. Grabowski, A. Sanner, Feste pharmazeutische Retardforme, European Patent 0 544 144 B1, BASF Aktiengesellschaft, 1992.
2. Breitenbach J., Grabowski S., and Rosenberg J. Extrusion von Polymer-Wirkstoff-Gemischen zur Herstellung von Arzneiformen. Spektrum der Wissenschaft (1995) 18-20
3. Breitenbach J. Melt extrusion: from process to drug delivery technology. Eur. J. Pharm. Biopharm. 54 2 (2002) 107-117
4. McGinity J.W., Koleng J.J., Repka M.A., and Zhang F. Hot-melt extrusion technology. In: Swarbrick J., and Boylan J.C. (Eds). Encyclopedia of Pharmaceutical Technology vol. 19 (2001), Marcel Dekker, New York 203-226
5. Follonier N., Doelker E., and Cole E.T. Evaluation of hot-melt extrusion as a new technique for the production of polymer based pellets for sustained release capsules containing high loadings of freely soluble drugs. Drug Dev. Ind. Pharm. 20 8 (1994) 1323-1339
6. Follonier N., Doelker E., and Cole E.T. Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials. J. Control. Release 36 (1995) 243-250
7. De Brabander C., Vervaet C., and Remon J.P. Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion. J. Control. Release 89 2 (2003) 235-247
8. Van Den Abeele W.M., De Brabander C., Vervaet C., Remon J.P., and Van Bortel L.M. Bioavailability of ibuprofen from hot-melt extruded mini-matrices. Br. J. Clin. Pharmacol. 57 3 (2004) 366-367
9. De Brabander C., Vervaet C., Van Bortel L., and Remon J.P. Bioavailability of ibuprofen from hot-melt extruded mini-matrices. Int. J. Pharm. 271 1-2 (2004) 77-84
10. Verhoeven E., Vervaet C., and Remon J.P. Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation. Eur. J. Pharm. Biopharm. 63 (2006) 320-330
11. De Brabander C., Van den Mooter G., Vervaet C., and Remon J.P. Characterisation of ibuprofen as a non-traditional plasticizer of ethyl cellulose. J. Pharm. Sci. 91 7 (2002) 1678-1685
12. Aitken-Nichol C., Zhang F., and McGinity J.W. Hot-melt extrusion of acrylic films. Pharm. Res. 13 (1996) 804-808
13. Frohoff-Hülsmann M.A., Schmitz A., and Lippold B.C. Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methylcellulose as coating material for diffusion pellets. I. Drug release rates from coated pellets. Int. J. Pharm. 177 (1999) 69-82
14. Frohoff-Hülsmann M.A., Schmitz A., Lippold B.C., and McGinity J.W. Aqueous ethyl cellulose dispersion containing plasticizers of different water solubility and hydroxypropyl methylcellulose as coating material for diffusion pellets. II. Properties of sprayed films. Eur. J. Pharm. Biopharm. 48 (1999) 67-75
15. Lecomte F., Siepmann J., Walther M., MacRae R.J., and Bodmeier R. Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer. J. Control. Release 99 (2004) 1-13
16. Miyagawa Y., Okabe T., Yamaguchi Y., Miyajima M., and Sunada H. Controlled-release of diclofenac sodium from wax matrix granule. Int. J. Pharm. 138 (1996) 215-254
17. Sato H., Miyagawa Y., and Okabe T. Dissolution mechanism of diclofenac sodium from wax matrix granules. J. Pharm. Sci. 86 (1997) 929-934
18. Repka M.A., Gerding T.G., Repka S.L., and McGinity J.W. Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot-melt extrusion. Drug Dev. Ind. Pharm. 25 5 (1999) 627-635
19. Zhang F., and McGinity J.W. Properties of sustained release tablets prepared by hot-melt extrusion. Pharm. Dev. Tech. 4 2 (1998) 241-250
20. Chokshi R., and Hossein Z. Hot-melt extrusion technique: a review. Iran. J. Pharm. Res. 3 (2004) 3-16
21. Nakamichi K., Nakano T., Yasuura H., Izumi S., and Kawashima Y. The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder. Int. J. Pharm. 241 (2002) 203-211
22. Nakamichi K., Nakano T., Yasuura H., Izumi S., and Kawashima Y. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur. J. Pharm. Biopharm. 56 (2003) 347-354
23. Henrist D., and Remon J.P. Influence of the process parameters on the characteristics of starch based hot stage extrudates. Int. J. Pharm. 189 (1999) 7-17