Understanding the tendency of amorphous solid dispersions to undergo amorphous-amorphous phase separation in the presence of absorbed moisture

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1209-1219

  Rumondor, Alfred C F ^a   Wikström, Håkan ^b   Van Eerdenbrugh, Bernard ^a,c   Taylor, Lynne S ^a  

^a PURDUE UNIVERSITY   (United States)

^b ASTRAZENECA R AND D   (Sweden)

^c DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

amorphous; amorphous solid dispersion; partial least squares (PLS); sorbed moisture

Indexed keywords

PHARMACEUTICAL VEHICLES AND ADDITIVES; POLYMER;

ABSORPTION; AMORPHOUS SOLID; ARTICLE; CHEMICAL STRUCTURE; DISPERSION; DRUG BIOAVAILABILITY; HUMIDITY; HYDROPHOBICITY; INFRARED SPECTROMETRY; MISCIBILITY; MOISTURE; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; SOLID STATE;

ABSORPTION; CHEMISTRY, PHARMACEUTICAL; DISCRIMINANT ANALYSIS; DRUG COMPOUNDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LEAST-SQUARES ANALYSIS; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; POVIDONE; SOLVENTS; SPECTROPHOTOMETRY, INFRARED; TECHNOLOGY, PHARMACEUTICAL; WATER; WETTABILITY;

EID: 83555168268     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9686-y     Document Type: Article

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