Characterisation and prediction of phase separation in hot-melt extruded solid dispersions: A thermal, microscopic and NMR relaxometry study

Pharmaceutical Research

Volumn 27, Issue 9, 2010, Pages 1869-1883

  Qi, Sheng ^a   Belton, Peter ^a   Nollenberger, Kathrin ^b   Clayden, Nigel ^a   Reading, Mike ^a   Craig, Duncan Q M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b Evonik Rohm GmbH   (Germany)

Author keywords

heat capacity; hot melt extrusion; miscibility; phase separation; supersaturation

Indexed keywords

EUDRAGIT; FELODIPINE;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; ENTHALPY; MISCIBILITY; PHASE SEPARATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCANNING ELECTRON MICROSCOPY; TEMPERATURE SENSITIVITY; THERMOGRAVIMETRY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; FELODIPINE; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; PHASE TRANSITION; POLYMETHACRYLIC ACIDS; PREDICTIVE VALUE OF TESTS; SOLUBILITY; STRESS, MECHANICAL; SURFACE PROPERTIES; THERMOGRAVIMETRY; TRANSITION TEMPERATURE;

EID: 77955471047     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0185-8     Document Type: Article

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