Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 3, 2012, Pages 683-689

  Dierickx, L ^a   Saerens, L ^a   Almeida, A ^a   De Beer, T ^a   Remon, J P ^a   Vervaet, C ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Co extrusion; Hot melt extrusion; Multiple unit dosage form; Polycaprolactone; Polyethylene oxide; Sustained release

Indexed keywords

ETHYL CELLULOSE; EUDRAGIT; EUDRAGIT RS; HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS METOPROLOL TARTRATE; MACROGOL; METOPROLOL TARTRATE; POLYCAPROLACTONE; POLYMER; POVIDONE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLLOID; DIFFERENTIAL SCANNING CALORIMETRY; DOG; DRUG COATING; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG MIXTURE; GOOD MANUFACTURING PRACTICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PELLET EXTRUSION; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SUSTAINED DRUG RELEASE; TEMPERATURE MEASUREMENT; X RAY DIFFRACTION;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DIURETICS; DRUG COMBINATIONS; DRUG COMPOUNDING; EXCIPIENTS; HOT TEMPERATURE; HYDROCHLOROTHIAZIDE; METOPROLOL; POLYESTERS; POLYETHYLENE GLYCOLS; SPECTRUM ANALYSIS, RAMAN; TABLETS; TIME FACTORS; X-RAY DIFFRACTION;

EID: 84863785898     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.03.018     Document Type: Article

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