The preparation of a solid dispersion powder of indomethacin with crospovidone using a twin-screw extruder or kneader

International Journal of Pharmaceutics

Volumn 365, Issue 1-2, 2009, Pages 53-60

  Shibata, Yusuke ^a,b   Fujii, Makiko ^a   Sugamura, Yuka ^a   Yoshikawa, Ryusuke ^c   Fujimoto, Shinji ^c   Nakanishi, Sayaka ^a   Motosugi, Yuya ^a   Koizumi, Naoya ^a   Yamada, Masaki ^b   Ouchi, Kiyohisa ^b   Watanabe, Yoshiteru ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b KISSEI PHARMACEUTICAL CO LTD   (Japan)

^c Kurimoto Center for Innovative Technology Kurimoto   (Japan)

Author keywords

Crospovidone; Indomethacin; Powder; Solid dispersion; Twin screw extruder or kneader

Indexed keywords

CROSPOVIDONE; INDOMETACIN;

APPARATUS; ARTICLE; DRUG MANUFACTURE; DRUG SOLUBILITY; HEATING; HIGH TEMPERATURE; MELTING POINT; POWDER; PRIORITY JOURNAL; ROTATION; SOLID DISPERSION POWDER; TEMPERATURE DEPENDENCE; TWIN SCREW EXTRUDER; TWIN SCREW KNEADER; VELOCITY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; INDOMETHACIN; POVIDONE; POWDERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TRANSITION TEMPERATURE;

EID: 57049147431     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.08.023     Document Type: Article

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