Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets

International Journal of Pharmaceutics

Volumn 361, Issue 1-2, 2008, Pages 158-168

  Schilling, Sandra U ^a   Bruce, Caroline D ^a   Shah, Navnit H ^b   Malick, A Waseem ^b   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

Citric acid; Diltiazem; Eudragit RS PO; Hot melt extrusion; Matrix tablet; Solid dispersion

Indexed keywords

CITRIC ACID; DILTIAZEM; EUDRAGIT; MACROGOL; MACROGOL 3350; PLASTICIZER; POLYMER; SODIUM CHLORIDE; SUCROSE;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG RELEASE; DRUG SOLUBILITY; MISCIBILITY; PARTICLE SIZE; PERMEABILITY; POROSITY; PREFORMULATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TABLET FORMULATION; THERMOSTABILITY; X RAY DIFFRACTION;

CALCIUM CHANNEL BLOCKERS; CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DILTIAZEM; DRUG CARRIERS; DRUG STABILITY; EXCIPIENTS; HEAT; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; POWDER DIFFRACTION; SOLUBILITY; TABLETS;

EID: 47949116811     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.05.035     Document Type: Article

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