Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 3, 2008, Pages 772-779

  De Beer, T R M ^a   Bodson, C ^b   Dejaegher, B ^c   Walczak, B ^d   Vercruysse, P ^a   Burggraeve, A ^a   Lemos, A ^a   Delattre, L ^b   Heyden, Y Vander ^c   Remon, J P ^a   Vervaet, C ^a   Baeyens, W R G ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c PHARMACEUTICAL INSTITUTE   (Belgium)

^d UNIVERSITY OF SILESIA   (Poland)

Author keywords

Blending; Experimental design; In line monitoring; MD; NIR spectroscopy; Orthogonal distance; PAT; Process understanding; Raman spectroscopy; SIMCA

Indexed keywords

DILTIAZEM; SILICON DIOXIDE;

ARTICLE; BIOMEDICAL TECHNOLOGY ASSESSMENT; BLENDING TIME; DIAGNOSTIC VALUE; IN LINE MONITORING; NEAR INFRARED SPECTROSCOPY; NONHUMAN; POWER BLENDING PROCESS; PRIORITY JOURNAL; PROCESS ANALYTICAL TECHNOLOGY TOOL; PROCESS MODEL; PROCESS MONITORING; RAMAN SPECTROMETRY; REAL TIME ENDPOINT MONITORING; RESPONSE VARIABLE; TIME;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DILTIAZEM; DRUG CARRIERS; DRUG COMPOUNDING; LACTOSE; POWDERS; SILICON DIOXIDE; SPECTROSCOPY, NEAR-INFRARED; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL;

EID: 53049084592     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.07.023     Document Type: Article

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