Investigating the effect of moisture protection on solid-state stability and dissolution of fenofibrate and ketoconazole solid dispersions using PXRD, HSDSC and Raman microscopy

Drug Development and Industrial Pharmacy

Volumn 37, Issue 9, 2011, Pages 1026-1035

  Kanaujia, Parijat ^a   Lau, Grace ^a   Ng, Wai Kiong ^a   Widjaja, Effendi ^a   Schreyer, Martin ^a   Hanefeld, Andrea ^b   Fischbach, Matthias ^b   Saal, Christoph ^b   Maio, Mario ^b   Tan, Reginald B H ^a,c  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b MERCK KGAA   (Germany)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Degree of crystallinity; Melt extrusion; Moisture protection; Solid dispersion; Stability studies

Indexed keywords

FENOFIBRATE; KETOCONAZOLE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; MOISTURE; RAMAN SPECTROMETRY; SOLID STATE; X RAY DIFFRACTION;

14-ALPHA DEMETHYLASE INHIBITORS; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DRUG STABILITY; FENOFIBRATE; HUMIDITY; HYPOLIPIDEMIC AGENTS; KETOCONAZOLE; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; X-RAY DIFFRACTION;

EID: 79961136829     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.558091     Document Type: Article

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