Upscaling of the hot-melt extrusion process: Comparison between laboratory scale and pilot scale production of solid dispersions with miconazole and Kollicoat® IR

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 3, 2012, Pages 674-682

  Guns, Sandra ^a   Mathot, Vincent ^a,b   Martens, Johan A ^a   Van Den Mooter, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SciTe BV   (Netherlands)

Author keywords

Hot melt extrusion; Kollicoat IR; Miconazole; Modulated differential scanning calorimetry; Solid dispersions; Upscaling

Indexed keywords

KOLLICOAT IR; MICONAZOLE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MANUFACTURE; DRUG STABILITY; HOT MELT EXTRUSION; KINETICS; LABORATORY; MISCIBILITY; PREDICTIVE VALUE; SCALE UP; SOLID; STORAGE TEMPERATURE; TEMPERATURE; X RAY POWDER DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; EQUIPMENT DESIGN; HOT TEMPERATURE; MICONAZOLE; POLYVINYLS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84863779507     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.03.020     Document Type: Article

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