Amorphization of pharmaceutical compound by co-precipitation using supercritical anti-solvent (SAS) process (Part I)

Journal of Supercritical Fluids

Volumn 53, Issue 1-3, 2010, Pages 179-184

  Lim, Ron Tau Yee ^a   Ng, Wai Kiong ^a   Tan, Reginald B H ^a,b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Amorphization; Anti solvent; Co precipitation; Indomethacin; Physical stability; Supercritical fluid

Indexed keywords

AMORPHOUS CHARACTERS; AMORPHOUS CONTENT; ANTI-SOLVENTS; BEFORE AND AFTER; CO-PRECIPITATES; CO-PRECIPITATION PROCESS; CRYSTALLINE FORM; CRYSTALLINITIES; INDOMETHACIN; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; PHARMACEUTICAL COMPOUNDS; PHYSICAL STABILITY; POLYMER COMPOSITE; POLYVINYL PYRROLIDONE; ROOM TEMPERATURE; SEM; SOLUBILITY ENHANCEMENT; STRESS TEST; SUPER-CRITICAL; SUPERCRITICAL CARBON DIOXIDES; WATERSOLUBLE POLYMERS; X RAY DIFFRACTOMETRY; X-RAY AMORPHOUS;

AMORPHIZATION; CARBON DIOXIDE; CRYSTALLINE MATERIALS; DISSOLUTION; EFFLUENT TREATMENT; MORPHOLOGY; POLYMERS; PRECIPITATION (CHEMICAL); SCANNING ELECTRON MICROSCOPY; SOLVENTS; STABILITY; SUPERCRITICAL FLUID EXTRACTION; SUPERCRITICAL FLUIDS; THERMOGRAVIMETRIC ANALYSIS; X RAY DIFFRACTION; X RAY DIFFRACTION ANALYSIS;

SYNTHETIC APERTURE SONAR;

EID: 77951622107     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2010.01.003     Document Type: Article

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