Enhanced in vivo absorption of CB-1 antagonist in rats via solid solutions prepared by hot-melt extrusion

Drug Development and Industrial Pharmacy

Volumn 37, Issue 6, 2011, Pages 694-701

  Ranzani, L S ^a   Font, J ^a   Galimany, F ^a   Santanach, A ^a   Gomez Gomar, A M ^a   Casadevall, G ^a   Gryczke, A ^b  

^a Laboratorios Esteve   (Spain)

^b Evonick Rohm GmbH Pharma Polymere   (Germany)

Author keywords

bioavailability; CB 1 antagonist; dissolution test sink conditions; Hot melt extrusion; solid dispersion; supersaturation

Indexed keywords

ACRYLIC ACID ETHYL ESTER; CANNABINOID 1 RECEPTOR ANTAGONIST; MACROGOL 8000; METHACRYLIC ACID METHYL ESTER; POVIDONE; VINYL ACETATE;

ANIMAL EXPERIMENT; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; IN VITRO STUDY; LIPOPHILICITY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; REVIEW; THERMOSTABILITY;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; HOT TEMPERATURE; MALE; METHACRYLATES; POLYETHYLENE GLYCOLS; POVIDONE; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; SOLUBILITY;

EID: 79955969587     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.535822     Document Type: Review

References (19)

1. Repka MA, McGinity JW, Zhang F, Koleng JJ. (2002). Hot melt extrusion technology. In: Swarbrick J, Boylan J, eds. Encyclopedia of Pharmaceutical Technology. Second edition. New York, NY: Marcel Dekker, 203-266.
2. Breitenbach J. (2002). Melt extrusion: from process to drug delivery technology. Eur j Pharm Biopharm, 54:107-117. (Pubitemid 34919382)
3. Forster A, Hempenstall J, Tucker I, Rades T. (2001). Selection of excipients for melt extrusion with two poorly soluble drugs by solubility parameter calculation and thermal analysis. Int J Pharm 226, 147-161. (Pubitemid 32800790)
4. Hülsman S, Backensfeld T, Keitel S, Bodmeier R. (2000). Melt extrusion an alternative method for enhancing the dissolution rate of 17 B-estradiol hemihydrate. Eur J Pharm Biopharm 49, 237-242. (Pubitemid 30229872)
5. Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Battu SK, McGinity JW, Martin C. (2007). Pharmaceutical applications of hot-melt extrusion: part I. Drug Dev Ind Pharm 33, 909-926. (Pubitemid 47463803)
6. Miller-Chou BA, Koening JL. (2003). A review of polymer dissolution. Prog Polym Sci 28, 1223-1270.
7. Perissutti B, Newton JM, Podczeck F, Rubessa F. (2002). Preparation of extruded carbamazepine and PEG 4000 as a potential rapid release dosage form. Eur j Pharm Biopharm, 53:125-132. (Pubitemid 34037004)
8. He H, Yang R, Tang X. (2010). In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hot-melt extrusion. Drug Dev Ind Pharm 36, 681-687.
9. Coleman MM, Painter PC. (2006). Miscible Polymer Blends: Background and Guide for Calculations and Design. Lancaster, PA: Destech Pubns Inc.
10. Lloyd R, Craig DQM, Smith A. (1997). An investigation into the melting behaviour of binary mixes and solid dispersions of paracetamol and PEG 4000. J Pharm Sci 86, 991-996. (Pubitemid 27382898)
11. Miller DA, McConville JT, Yang W, Williams RO, McGinity JW. (2007). Hot-melt extrusion for enhanced delivery of drug particles. J Pharm Sci 96, 361-376. (Pubitemid 46363567)
12. Connors RD, Elder EJ. Solubilization solutions "on line". http:// www.drugdeliverytech.com issue date; vol.4 No. 8 October 2004.
13. Greenhalgh DJ, Williams AC, Timmins P, York P. (1999). Solubility parameters as predictors of miscibility in solid dispersions. J Pharm Sci, 88:1182-1190. (Pubitemid 29526305)
14. Zheng X, Yang R, Zhang Y, Wang Z, Tang X, Zheng L. (2007a). Part I characterisation of solid dispersions of Nimodipine prepared by hot melt extrusion. Drug Dev Ind Pham 33, 791-802. (Pubitemid 47123802)
15. Leuner C, Dressman J. (2000). Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm, 50: 47-60. (Pubitemid 30326688)
16. Wang L, Cui FD, Hayase T, Sunada H. (2005). Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder. Chem Pharm Bull, 53:1240-1245. (Pubitemid 41425615)
17. Rambali B, Verreck G, Baert L, Massart DL. (2003). Itraconazole formulation studies of melt extrusion process with mixture design. Drug Dev Ind Pharm 29, 641-652. (Pubitemid 36835157)
18. Bailer A. (1988). John Testing for the equality of area under the curves when using destructive measurement techniques. J Pharmacokin Biopharm 16, 303-309.
19. Zheng X, Yang R, Zhang Y, Wang Z, Tang X, Zheng L. (2007b). Bioavailability in beagle dogs of Nimodipine solid dispersions prepared by hot-melt extrusion. Drug Dev Ind Pharm 33, 783-789. (Pubitemid 47123804)