In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 1, 2012, Pages 230-237

  Saerens, Lien ^a   Dierickx, Lien ^a   Quinten, Thomas ^a   Adriaensens, Peter ^b   Carleer, Robert ^b   Vervaet, Chris ^a   Remon, Jean Paul ^a   De Beer, Thomas ^a  

^a GHENT UNIVERSITY   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

Author keywords

Continuous production; Hot melt extrusion (HME); In line monitoring; NIR spectroscopy; Process Analytical Technology (PAT)

Indexed keywords

METOPROLOL TARTRATE; POVIDONE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG CONCENTRATION; DRUG FORMULATION; DRUG MIXTURE; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; HOT MELT EXTRUSION; HYDROGEN BOND; MOLECULAR INTERACTION; NEAR INFRARED SPECTROSCOPY; RAMAN SPECTROMETRY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HOT TEMPERATURE; HYDROGEN BONDING; LEAST-SQUARES ANALYSIS; METOPROLOL; MODELS, STATISTICAL; POLYMERS; POVIDONE; SPECTROSCOPY, NEAR-INFRARED; SPECTRUM ANALYSIS, RAMAN;

EID: 84861098743     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.01.001     Document Type: Article

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