Fusion production of solid dispersions containing a heat-sensitive active ingredient by hot melt extrusion and Kinetisol® dispersing

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 74, Issue 2, 2010, Pages 340-351

  DiNunzio, James C ^a   Brough, Chris ^b   Hughey, Justin R ^a   Miller, Dave A ^a   Williams III, Robert O ^a   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b DisperSol Technologies LLC   (United States)

Author keywords

Degradation; Hot melt extrusion; Hydrocortisone; KinetiSol Dispersing; Solid dispersion; Thermal processing; Thermal stability

Indexed keywords

1 VINYL 2 PYRROLIDINONE; HYDROCORTISONE; HYDROXYPROPYLMETHYLCELLULOSE; VINYL ACETATE;

ANALYTIC METHOD; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DECOMPOSITION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG MANUFACTURE; GLASS TRANSITION TEMPERATURE; HEAT SENSITIVITY; HIGH TEMPERATURE; HOT MELT EXTRUSION; HOT STAGE MICROSCOPY; INTERMETHOD COMPARISON; KINETISOL DISPERSING; LOW TEMPERATURE PROCEDURES; MEAN RESIDENCE TIME; MICROSCOPY; PHYSICAL CHEMISTRY; PREFORMULATION; PROCESS TECHNOLOGY; PRODUCT DEVELOPMENT; SOLUBILIZATION; THERMOGRAVIMETRY; THERMOSTABILITY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; HOT TEMPERATURE; HYDROCORTISONE; METHYLCELLULOSE; PHYSICOCHEMICAL PHENOMENA; POLYMERS; POVIDONE; SOLUBILITY;

EID: 75449093807     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.09.007     Document Type: Article

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