Dissolution enhancement of a drug exhibiting thermal and acidic decomposition characteristics by fusion processing: A comparative study of hot melt extrusion and KinetiSol® Dispersing

AAPS PharmSciTech

Volumn 11, Issue 2, 2010, Pages 760-774

  Hughey, Justin R ^a   Di Nunzio, James C ^a,b   Bennett, Ryan C ^a   Brough, Chris ^c   Miller, Dave A ^d   Ma, Hua ^d   Williams III, Robert O ^a   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b PharmaForm LLC   (United States)

^c DisperSol Technologies LLC   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

Acid labile; Hot melt extrusion; KinetiSol Dispersing; Solid dispersion; Thermally labile

Indexed keywords

EUDRAGIT; POLYMER; DRUG; WATER;

ACIDITY; ARTICLE; COMPARATIVE STUDY; DISPERSION; DRUG DECOMPOSITION; DRUG SOLUBILITY; DRUG STABILITY; IMAGE ANALYSIS; PARTICLE SIZE; PREFORMULATION; PRIORITY JOURNAL; THERMOSTABILITY; CHEMISTRY; DRUG FORMULATION; HEAT; PH; PROCEDURES; SOLUBILITY;

DRUG COMPOUNDING; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; WATER;

EID: 77955688263     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9431-y     Document Type: Article

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