Quantification of low levels (<10%) of amorphous content in micronised active batches using dynamic vapour sorption and isothermal microcalorimetry

International Journal of Pharmaceutics

Volumn 231, Issue 2, 2002, Pages 227-236

  Mackin, Lesley ^a,b   Zanon, Roger ^a   Park, Jung Min ^a   Foster, Kimberly ^a   Opalenik, Holly ^a   Demonte, Matt ^a  

^a Pharmacia RandD   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Amorphous; Dynamic vapour sorption; Glass transition temperature; Isothermal microcalorimetry; Micronisation; Moisture sorption

Indexed keywords

BENZYL DERIVATIVE; CRYSTALLIN; ETHER DERIVATIVE; SOLVENT;

ADSORPTION; ARTICLE; CONCENTRATION (PARAMETERS); CRYSTALLIZATION; DEVICE; DRUG FORMULATION; EVALUATION; MICROCALORIMETRY; MOISTURE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; THERMAL CONDUCTIVITY; VAPOR;

CALORIMETRY; DOSAGE FORMS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0037074074     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00881-X     Document Type: Article

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