Evaluation of drug-polymer miscibility in amorphous solid dispersion systems

Pharmaceutical Research

Volumn 26, Issue 11, 2009, Pages 2523-2534

  Rumondor, Alfred C F ^a,b   Ivanisevic, Igor ^c   Bates, Simon ^c   Alonzo, David E ^a   Taylor, Lynne S ^a  

^a PURDUE UNIVERSITY   (United States)

^b ASTRAZENECA   (United Kingdom)

^c Aptuit Inc   (United States)

Author keywords

Amorphous solid dispersions; Calorimetry; Differential scanning; Infrared spectroscopy; Miscibility; Powder X ray diffractometry

Indexed keywords

FELODIPINE; K 2932; KETOCONAZOLE; NIFEDIPINE; POLYACRYLIC ACID; POVIDONE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG STRUCTURE; INFRARED SPECTROSCOPY; MISCIBILITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; X RAY POWDER DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; FELODIPINE; KETOCONAZOLE; MODELS, BIOLOGICAL; NIFEDIPINE; POLYMERS; POWDERS; PYRROLIDINONES; SOLUBILITY; THERMODYNAMICS; WATER; X-RAY DIFFRACTION;

EID: 70350220585     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9970-7     Document Type: Article

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