Development of a HPMC-based controlled release formulation with hot melt extrusion (HME)

Drug Development and Industrial Pharmacy

Volumn 39, Issue 7, 2013, Pages 1070-1083

  Ma, Decheng ^a   Djemai, Abdenour ^b   Gendron, Colleen M ^c   Xi, Hanmi ^c   Smith, Michelle ^c   Kogan, Jessica ^c   Li, Li ^c  

^a Pharmaceutical Science and Clinical Supply   (China)

^b Merck Sharp & Dohme Limited   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Controlled release (CR); Crystalline; Hot melt extrusion (HME); Hydroxypropyl methylcellulose (methocel, HPMC); Propylene glycol (PG); Theophylline

Indexed keywords

EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; PLACEBO; POLYMER; PROPYLENE GLYCOL; THEOPHYLLINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG DIFFUSION; DRUG DOSAGE FORM; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STABILITY; DRUG TRANSPORT; GLASS TRANSITION TEMPERATURE; HOT MELT EXTRUSION; MELTING POINT; MOLECULAR WEIGHT; SUSTAINED DRUG RELEASE; THERMOGRAVIMETRY; THERMOSTABILITY; TORQUE; VISCOSITY; X RAY POWDER DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; EXCIPIENTS; METHYLCELLULOSE; MODELS, THEORETICAL; PROPYLENE GLYCOL; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THEOPHYLLINE; TORQUE;

EID: 84878888611     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.702350     Document Type: Article

References (20)

1. Langer R. (1981). Controlled release: A new approach to drug delivery. Tech Rev, 83:26-34.
2. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. (1999). Polymeric systems for controlled drug release. Chem Rev, 99:3181-3198.
3. Upton C, Kelly C, Shakesheff K, Howdle S. (2007). Perspective - one dose or two? The use of polymers in drug delivery. Poly Int, 56:1457-1460.
4. Mansour HM, Sohn M, Al-Ghananeem A, Deluca PP. (2010). Materials for pharmaceutical dosage forms: Molecular pharmaceutics and controlled release drug delivery aspects. Int J Mol Sci, 11:3298-3322.
5. Wen H, Park K. (2010). Oral controlled release formulation design and drug delivery. New York: John Wiley & Sons.
6. Mitchell K, Ford J, Armstrong D, Elliott P, Rostron C, Hogan J. (1993). The influence of concentration on the release of drugs from gels and matrices containing Methocel. Int J Pharm, 100: 155-163.
7. Coppens K, Hall M, Mitchell S, Read M. (2006). Hypromellose, ethylcellulose, and polyethylene oxide use in hot melt extrusion. Pharma Tech, 30:62-70.
8. Hardy IJ, Cook WG, Melia CD. (2006). Compression and compaction properties of plasticised high molecular weight hydroxypropylmethylcellulose (HPMC) as a hydrophilic matrix carrier. Int J Pharm, 311:26-32.
9. Ghebre-Sellassie I, Martin C. (2007). Pharmaceutical extrusion technology: Drugs and the pharmaceutical sciences. Volume 133. New York: Informa Healthcare Inc.
10. (2010). Using Dow excipients for controlled release of drugs in hydrophilic matrix systems. Dow chemical company brochure. 8-14.
11. Huang Y, Zheng LL, Liu J, Zhang ZR. (2005). Synthesis and characterization of HPMC derivatives as novel duodenum-specific coating agents. Arch Pharm Res, 28:364-369.
12. Bird R, Stewart W, Lightfoot E. (2002). Transport phenomena. 2nd ed. New York: Wiley, 529.
13. Kumar N. (1980). Viscosity-molecular weight-temperature-shear rate relationships of polymer melts: A literature review. J Polym Sci Macromol Rev, 15: 255-325.
14. Franz R, Systma J, Smith B, Lucisano L. (1987). In vitro evaluation of a mixed polymeric sustained release matrix using response surface methodology. J Control Rel, 5:159-172.
15. Bonferoni M, Caramella C, Sangalli M, Conte U, Hernandez R, Pedraz J. (1992). Rheological behaviour of hydrophilic polymers and drug release from erodible matrices. J Control Rel, 18:205-212.
16. (2010). Methocel cellulose ethers. Dow chemical technical handbook. 15.
17. Siepmann J, Peppas N. (2001). Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev, 48:139-157.
18. Peppas N. (1984). Release of bioactive agents from swellable polymers: Theory and experiments. In: Anderson J, Kim S, ed. Recent advances in drug delivery systems. New York: Plenum publishing corporation, 279-289.
19. Peppas N, Sahlin J. (1989). A simple equation for the description of solute release. III. Coupling of diffusion and relaxation. Int J Pharm, 57:169-172.
20. Yang M, Wang P, Huang CY, Ku MS, Liu H, Gogos C. (2010). Solid dispersion of acetaminophen and poly(ethylene oxide) prepared by hot-melt mixing. Int J Pharm, 395:53-61.