The mTOR signalling pathway in human cancer

International Journal of Molecular Sciences

Volumn 13, Issue 2, 2012, Pages 1886-1918

  Pópulo, Helena ^a,b   Lopes, José Manuel ^a,b,c   Soares, Paula ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

Cancer; Melanoma; mTOR; Rapamycin; Therapy

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; BEVACIZUMAB; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OLCOROLIMUS; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; RAPAMYCIN DERIVATIVE; RIDAFOROLIMUS; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TRASTUZUMAB; VEMURAFENIB; XL 765; ZOTAROLIMUS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MTOR PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

B CELL LYMPHOMA; BREAST CANCER; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; DOSE RESPONSE; DRUG APPROVAL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENDOCRINE TUMOR; ENDOMETRIUM CANCER; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GLIOBLASTOMA; GLIOMA; HODGKIN DISEASE; HUMAN; INTRACELLULAR SIGNALING; KIDNEY ALLOGRAFT REJECTION; KIDNEY CARCINOMA; LUNG SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MANTLE CELL LYMPHOMA; MELANOMA; METASTASIS; NONHODGKIN LYMPHOMA; NONHUMAN; ONCOGENE; ONCOGENE N RAS; ONCOGENE RAS; OSTEOSARCOMA; PANCREAS CANCER; PHOSPHATASE AND TENSIN HOMOLOGUE DELETED ON CHROMOSOME TEN GENE; PHOSPHATIDYLINOSITOL 3 KINASE GENE; PROSTATE CANCER; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RECEPTOR BINDING; REVIEW; RHABDOMYOSARCOMA; SKIN CARCINOGENESIS; SOLID TUMOR; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; UNSPECIFIED SIDE EFFECT; ANIMAL; CHEMISTRY; GENETICS; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; METABOLISM; NEOPLASMS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN TUMOR;

MAMMALIA;

ANIMALS; GROWTH AND DEVELOPMENT; HUMANS; LONGEVITY; MELANOMA; MULTIPROTEIN COMPLEXES; NEOPLASMS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TOR SERINE-THREONINE KINASES;

EID: 84857675728     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13021886     Document Type: Review

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