The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

Molecular and Cellular Biology

Volumn 21, Issue 3, 2001, Pages 743-754

  Scheper, G C ^a   Morrice, N A ^a   Kleijn, M ^a   Proud, C G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; INITIATION FACTOR 4E; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-4E; FLAVONOIDS; HUMANS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE INITIATION FACTORS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0035133659     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.3.743-754.2001     Document Type: Article

References (40)

1. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
2. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo
3. eIF4E expression in tumors: Its possible role in progression of malignancies
4. Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology
5. Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor
6. Serine 209, not serine 53, is the major site of phophorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells
7. Malignant transformation by overproduction of translation initiation factor eIF4G
8. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
9. A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1
10. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
11. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
12. Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209
13. Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48S initiation complex
14. The proto-oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas
15. Phosphorylation of eIF-4E and initiation of protein synthesis in P19 embryonal carcinoma cells
16. mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E
17. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
18. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picomaviral proteases. Implications for cap-dependent and cap-independent translational initiation
19. Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E
20. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
21. Ras mediates translation initiation factor 4E-induced malignant transformation
22. Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma
23. Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E
24. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP
25. Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: Increased cap affinity of the phosphorylated form
26. Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region
27. Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells
28. Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells
29. Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas
30. Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer
31. Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1
32. Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E
33. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
34. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
35. Use of nonreducing SDS-PAGE for monitoring renaturation of recombinant protein synthesis initiation factor, eIF-4 alpha
36. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways
37. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
38. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
39. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression