-
1
-
-
33750155593
-
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
-
Avruch, J., K. Hara, Y. Lin, M. Liu, X. Long, S. Ortiz-Vega, and K. Yonezawa. 2006. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25: 6361-6372.
-
(2006)
Oncogene
, vol.25
, pp. 6361-6372
-
-
Avruch, J.1
Hara, K.2
Lin, Y.3
Liu, M.4
Long, X.5
Ortiz-Vega, S.6
Yonezawa, K.7
-
2
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar, D. C., and J. Blenis. 2004. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23: 3151-3171.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
3
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N., and N. Sonenberg. 2004. Upstream and downstream of mTOR. Genes Dev. 18: 1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
4
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., R. Loewith, and M. N. Hall. 2006. TOR signaling in growth and metabolism. Cell 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
5
-
-
0141893375
-
M-CSF, TNFα, and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase
-
Glantschnig, H., J. Fisher, G. Wesolowski, G. Rodan, and A. Reszka. 2001. M-CSF, TNFα, and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. Cell Death Differ. 10: 1165-1177.
-
(2001)
Cell Death Differ
, vol.10
, pp. 1165-1177
-
-
Glantschnig, H.1
Fisher, J.2
Wesolowski, G.3
Rodan, G.4
Reszka, A.5
-
6
-
-
34547605613
-
IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
-
Lee, D.-F., H.-P. Kuo, C.-T. Chen, J.-M. Hsu, C.-K. Chou, Y. Wei, H.-L. Sun, L.-Y. Li, B. Ping, W.-C. Huang, et al. 2007. IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130: 440-455.
-
(2007)
Cell
, vol.130
, pp. 440-455
-
-
Lee, D.-F.1
Kuo, H.-P.2
Chen, C.-T.3
Hsu, J.-M.4
Chou, C.-K.5
Wei, Y.6
Sun, H.-L.7
Li, L.-Y.8
Ping, B.9
Huang, W.-C.10
-
7
-
-
0035836770
-
A PI3K/AktAnTOR pathway mediates and PTEN antagonizes TNF inhibition of insulin signaling through insulin receptor substrate-1
-
Ozes, O., H. Akca, L. Mayo, J. Gustin, T. Maehama, J. Dixon, and D. Donner. 2001. A PI3K/AktAnTOR pathway mediates and PTEN antagonizes TNF inhibition of insulin signaling through insulin receptor substrate-1. Proc. Nat. Acad. Sci. USA 98: 4640-4645.
-
(2001)
Proc. Nat. Acad. Sci. USA
, vol.98
, pp. 4640-4645
-
-
Ozes, O.1
Akca, H.2
Mayo, L.3
Gustin, J.4
Maehama, T.5
Dixon, J.6
Donner, D.7
-
8
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
-
Inoki, K., Y. Li, T. Zhu, J. Wu, and K.-L. Guan. 2003. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell. Biol. 4: 648-657.
-
(2003)
Nat. Cell. Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
9
-
-
0347318056
-
TSC2: Filling the GAP in the mTOR signaling pathway
-
Li, Y., M. N. Corradetti, K. Inoki, and K.-L. Guan. 2004. TSC2: filling the GAP in the mTOR signaling pathway. Trends. Biochem. Sci. 29: 32-38.
-
(2004)
Trends. Biochem. Sci
, vol.29
, pp. 32-38
-
-
Li, Y.1
Corradetti, M.N.2
Inoki, K.3
Guan, K.-L.4
-
10
-
-
0347716759
-
Rheb fills a GAP between TSC and TOR
-
Manning, B. D., and L. C. Cantley. 2003. Rheb fills a GAP between TSC and TOR. Trends Biochem. Sci. 28: 573-576.
-
(2003)
Trends Biochem. Sci
, vol.28
, pp. 573-576
-
-
Manning, B.D.1
Cantley, L.C.2
-
11
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
Sancak. Y., C. Thoreen, T. Peterson, R. Lindquist, S. Kang, E. Spooner, S. Carr, and D. M. Sabatini. 2007. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol. Cell. 25: 903-915.
-
(2007)
Mol. Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.2
Peterson, T.3
Lindquist, R.4
Kang, S.5
Spooner, E.6
Carr, S.7
Sabatini, D.M.8
-
12
-
-
33847397874
-
Insulin signaling to mTOR mediated by the Akt/PKB substrate PRAS40
-
Vander Haar, E., S. Lee, S. Bandhakavi, T. Griffin, and D.-H. Kim. 2007. Insulin signaling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat. Cell. Biol. 9: 316-323.
-
(2007)
Nat. Cell. Biol
, vol.9
, pp. 316-323
-
-
Vander Haar, E.1
Lee, S.2
Bandhakavi, S.3
Griffin, T.4
Kim, D.-H.5
-
13
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K., Y. Maruki, X. Long, K. Yoshino, N. Oshiro, S. Hidayat, C. Tokunaga, J. Avruch, and K. Yonezawa. 2002. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110: 177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
14
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D.-H., D. Sarbassov, S. Ali, J. King, R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.-H.1
Sarbassov, D.2
Ali, S.3
King, J.4
Latek, R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
15
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex
-
Sarbassov, D., D. Guertin, S. M. Ali, and D. M. Sabatini. 2005. Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex. Science 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.1
Guertin, D.2
Ali, S.M.3
Sabatini, D.M.4
-
16
-
-
0037623417
-
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim, D.-H., D. Sarbassov, S. M. Ali, R. R. Latek, K. Guntur, H. Erdjument-Bromage, P. Tempt, and D. M. Sabatini. 2003. GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell. 11: 895-904.
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.-H.1
Sarbassov, D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.5
Erdjument-Bromage, H.6
Tempt, P.7
Sabatini, D.M.8
-
17
-
-
24944480788
-
The Akt-mTOR tango and its relevance to cancer
-
Hay, N. 2005. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 8: 179-183.
-
(2005)
Cancer Cell
, vol.8
, pp. 179-183
-
-
Hay, N.1
-
18
-
-
27844506524
-
Akt-regulated pathways in prostate cancer
-
Majumder, P. K., and W. R. Sellers. 2005. Akt-regulated pathways in prostate cancer. Oncogene 24: 7465-7474.
-
(2005)
Oncogene
, vol.24
, pp. 7465-7474
-
-
Majumder, P.K.1
Sellers, W.R.2
-
19
-
-
34250788809
-
Akt/PKB signaling: Navigating downstream
-
Manning, B. D., and L. C. Cantley. 2007. Akt/PKB signaling: navigating downstream. Cell 129: 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
20
-
-
0036632368
-
The phosphatidylinositol 3-kinase pathway and human cancer
-
Vivanco, I., and C. L. Sawyers. 2002. The phosphatidylinositol 3-kinase pathway and human cancer. Nat. Rev. Cancer 2: 489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
21
-
-
0033026165
-
Signaling by CD95 and TNF receptors: Not only life and death
-
Magnusson, C., and D. Vaux. 1999. Signaling by CD95 and TNF receptors: not only life and death. Immunol. Cell Biol. 77: 41-46.
-
(1999)
Immunol. Cell Biol
, vol.77
, pp. 41-46
-
-
Magnusson, C.1
Vaux, D.2
-
22
-
-
23144467910
-
An expanding role for mTOR in cancer
-
Guertin, D. A., and D. M. Sabatini. 2005. An expanding role for mTOR in cancer. Trends Mol. Med. 8: 353-361.
-
(2005)
Trends Mol. Med
, vol.8
, pp. 353-361
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
23
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the PI3K/Akt pathway
-
Cantley, L. C., and B. G. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the PI3K/Akt pathway. Proc. Natl. Acad. Sci. USA 96: 4240-4245.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
24
-
-
0032053709
-
Mechanisms and consequences of activation of protein ki-nase B/Akt
-
Downward, J. 1998. Mechanisms and consequences of activation of protein ki-nase B/Akt. Curr. Opin. Cell Biol. 10: 262-267.
-
(1998)
Curr. Opin. Cell Biol
, vol.10
, pp. 262-267
-
-
Downward, J.1
-
25
-
-
4444376712
-
Signaling to NF-κB
-
Hayden, M., and S. Ghosh. 2004. Signaling to NF-κB. Genes Dev. 18: 2195-2224.
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.1
Ghosh, S.2
-
26
-
-
33645999706
-
NF-κB and IKK as therapeutic targets in cancer
-
Kim, H. J., N. Hawke, and A. S. Baldwin. 2006. NF-κB and IKK as therapeutic targets in cancer. Cell Death Diff. 13: 738-747.
-
(2006)
Cell Death Diff
, vol.13
, pp. 738-747
-
-
Kim, H.J.1
Hawke, N.2
Baldwin, A.S.3
-
27
-
-
2342464085
-
The two NF-κB activation pathways and their roles in innate and adaptive immunity
-
Bonizzi, G., and M. Karin. 2004. The two NF-κB activation pathways and their roles in innate and adaptive immunity. Trends Immunol. 25: 280-288.
-
(2004)
Trends Immunol
, vol.25
, pp. 280-288
-
-
Bonizzi, G.1
Karin, M.2
-
28
-
-
0035379555
-
Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of IKK and activation of mitogen activated protein kinase p38
-
Madrid, L., M. Mayo, J. Reuther, and A. S. Baldwin. 2001. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of IKK and activation of mitogen activated protein kinase p38. J. Biol. Chem. 276: 18934-18940.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 18934-18940
-
-
Madrid, L.1
Mayo, M.2
Reuther, J.3
Baldwin, A.S.4
-
29
-
-
0037039665
-
Distinct roles of IKKaα and IKKβ in liberating NF-κB from IκB and in phosphor-ylating the p65 subunit of NF-κB
-
Sizemore, N., N. Lemer, N. Dombrowski, H. Sakurai, and G. Stark. 2002. Distinct roles of IKKaα and IKKβ in liberating NF-κB from IκB and in phosphor-ylating the p65 subunit of NF-κB. J. Biol. Chem. 277: 3863-3869.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 3863-3869
-
-
Sizemore, N.1
Lemer, N.2
Dombrowski, N.3
Sakurai, H.4
Stark, G.5
-
30
-
-
0345826140
-
Cell type-specific expression of the IκB kinases determines the significance of PI3K/Akt signaling to NF-κB activation
-
Gustin, J., O. Ozes, H. Akca, R. Pincheira, L. Mayo, Q. Li, J. Guzman, C. Korgaonkar, and D. Donner. 2004. Cell type-specific expression of the IκB kinases determines the significance of PI3K/Akt signaling to NF-κB activation. J. Biol. Chem. 279: 1615-1620.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 1615-1620
-
-
Gustin, J.1
Ozes, O.2
Akca, H.3
Pincheira, R.4
Mayo, L.5
Li, Q.6
Guzman, J.7
Korgaonkar, C.8
Donner, D.9
-
31
-
-
34447131534
-
Regulation of mammalian target of rapamycin activity in PTEN-inactive cancer cells by IKKα
-
Dan, H. C., M. Adli, and A. Baldwin. 2007. Regulation of mammalian target of rapamycin activity in PTEN-inactive cancer cells by IKKα. Cancer Res. 67: 6263-6269.
-
(2007)
Cancer Res
, vol.67
, pp. 6263-6269
-
-
Dan, H.C.1
Adli, M.2
Baldwin, A.3
-
32
-
-
0029831167
-
Direction inhibition of the signaling of the mammalian target of rapamycin by the PI3-kinase inhibitors, wortmannin and LY294002
-
Brunn, G., J. Williams, C. Sabers, G. Wiederrecht, J. Lawrence, and R. T. Abraham. 1996. Direction inhibition of the signaling of the mammalian target of rapamycin by the PI3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15: 5256-5267.
-
(1996)
EMBO J
, vol.15
, pp. 5256-5267
-
-
Brunn, G.1
Williams, J.2
Sabers, C.3
Wiederrecht, G.4
Lawrence, J.5
Abraham, R.T.6
-
33
-
-
19944374141
-
A selective novel low-molecular weight inhibitor of IκB kinase-β (IKKβ) prevents pulmonary inflammation and shows broad anti-inflammatory activity
-
Ziegelbauer, K., F. Gantner, N. Lukacs, A. Berlin, K. Fuchikami, T. Niki, K. Sakai, H. Inbe, K. Takeshita, M. Ishimori, et al. 2005. A selective novel low-molecular weight inhibitor of IκB kinase-β (IKKβ) prevents pulmonary inflammation and shows broad anti-inflammatory activity. Br. J. Pharmacol. 145: 178-192.
-
(2005)
Br. J. Pharmacol
, vol.145
, pp. 178-192
-
-
Ziegelbauer, K.1
Gantner, F.2
Lukacs, N.3
Berlin, A.4
Fuchikami, K.5
Niki, T.6
Sakai, K.7
Inbe, H.8
Takeshita, K.9
Ishimori, M.10
-
34
-
-
18544375193
-
PI3K/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
Dan, H. C., M. Sun, L. Yang, R. Friedman, X. Sui, C. Ou, M. Nellist, R. Yeung, D. Halley, R. Nicosia, et al. 2002. PI3K/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J. Biol. Chem, 277: 35364-35370.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
Friedman, R.4
Sui, X.5
Ou, C.6
Nellist, M.7
Yeung, R.8
Halley, D.9
Nicosia, R.10
|