PPARγ, 10 years later

Biochimie

Volumn 87, Issue 1 SPEC. ISS., 2005, Pages 9-13

  Lazar, Mitchell A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adipocyte; Diabetes; Insulin resistance; Obesity; PPARgamma

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CLOFIBRATE; FATTY ACID BINDING PROTEIN; GLUCOSE; HORMONE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR; INTERLEUKIN 6; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; CELL DIFFERENTIATION; CONFERENCE PAPER; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG EFFECT; DRUG POTENCY; GENE EXPRESSION; GENETIC POLYMORPHISM; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOGENESIS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHOSPHORYLATION;

EID: 14544303179     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biochi.2004.10.021     Document Type: Conference Paper

References (67)

1. D.J. Mangelsdorf, C. Thummel, and M. Beato The nuclear receptor superfamily: the second decade Cell 83 1995 835 839
2. N.J. McKenna, and B.W. O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474
3. H. Wang, Z.Q. Huang, and L. Xia Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor Science 293 2001 853 857
4. D. Chen, H. Ma, and H. Hong Regulation of transcription by a protein methyltransferase Science 284 1999 2174 2177
5. C.J. Fryer, and T.K. Archer Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex Nature 393 1998 88 91
6. B.D. Strahl, and C.D. Allis The language of covalent histone modifications Nature 403 2000 41 45
7. X. Hu, and M.A. Lazar Transcriptional repression by nuclear hormone receptors Trends Endocrinol. Metab. 11 2000 6 10
8. P.L. Jones, and Y.B. Shi N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors Curr. Top. Microbiol. Immunol. 274 2003 237 268
9. C.K. Glass, and M.G. Rosenfeld The coregulator exchange in transcriptional functions of nuclear receptors Genes Dev. 14 2000 121 141
10. C. Dreyer, G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors Cell 68 1992 879 887
11. F. Chen, S.W. Law, and B.W. O'Malley Identification of two mPPAR related receptors and evidence for the existence of five subfamily members Biochem. Biophys. Res. Commun. 196 1993 671 677
12. I. Issemann, and S. Green Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 1990 645 650
13. A. Werman, A. Hollenberg, G. Solanes, C. Bjorbaek, A.J. Vidal-Puig, and J.S. Flier Ligand-independent activation domain in the N terminus of PPARγ. Differential activity of PPARγ1and 2 isoforms and influence of insulin J. Biol. Chem. 272 1997 20230 20235
14. M. Adams, M.J. Reginato, D. Shao, M.A. Lazar, and V.K. Chatterjee Transcriptional activation by PPARγ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site J. Biol. Chem. 272 1997 5128 5132
15. H.S. Camp, and S.R. Tafuri Regulation of peroxisome proliferator- activated receptor γ activity by mitogen-activated protein kinase J. Biol. Chem. 272 1997 13452 13457
16. E. Hu, J.B. Kim, P. Sarraf, and B.M. Spiegelman Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ Science 274 1996 2100 2103
17. H.S. Camp, S.R. Tafuri, and T. Leff c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity Endocrinology 140 1999 392 397
18. M.J. Reginato, S.L. Krakow, S.T. Bailey, and M.A. Lazar Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor γ J. Biol. Chem. 273 1998 1855 1858
19. M. Ristow, D. Muller-Wieland, A. Pfeiffer, W. Krone, and C.R. Kahn Obesity associated with a mutation in a genetic regulator of adipocyte differentiation N. Engl. J. Med. 339 1998 953 959
20. D. Shao, S.M. Rangwala, S.T. Bailey, S.L. Krakow, M.J. Reginato, and M.A. Lazar Interdomain communication regulating PPARγ ligand binding Nature 396 1998 377 380
21. B. Zhang, J. Berger, and G. Zhou Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ J. Biol. Chem. 271 1996 31771 31774
22. R.F. Kletzien, S.D. Clarke, and R.G. Ulrich Enhancement of adipocyte differentiation by an insulin-sensitizing agent Mol. Pharm. 41 1992 393 398
23. E.Z. Amri, G. Ailhaud, and P.A. Grimaldi Fatty acids as signal transducing molecules: involvement in the differentiation of preadipose to adipose cells J. Lipid Res. 35 1994 930 937
24. A. Chawla, and M.A. Lazar Peroxisome proliferator and retinoid signalling pathways coregulate preadipocyte phenotype and survival Proc. Natl. Acad. Sci. USA 91 1994 1786 1790
25. P. Tontonoz, E. Hu, R.A. Graves, A.I. Budavari, and B.M. Spiegelman mPPARγ2: tissue-specific regulator of an adipocyte enhancer Genes Dev. 8 1994 1224 1234
26. A. Chawla, E.J. Schwarz, D.D. Dimaculangan, and M.A. Lazar Peroxisome proliferator-activated receptor γ (PPARγ): adipose predominant expression and induction early in adipocyte differentiation Endocrinology 135 1994 798 800
27. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for the nuclear peroxisome proliferator-activated receptor γ (PPARγ) J. Biol. Chem. 270 1995 12953 12956
28. P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor Cell 79 1994 1147 1156
29. E. Hu, P. Tontonoz, and B.M. Spiegelman Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα Proc. Natl. Acad. Sci. USA 92 1995 9856 9860
30. D. Shao, and M.A. Lazar PPARγ, C/EBPα, cell cycle status and the commitment to adipocyte differentiation J. Biol. Chem. 272 1997 21473 21478
31. Y. Barak, M.C. Nelson, and E.S. Ong PPARγ is required for placental, cardiac, and adipose tissue development Mol. Cell 4 1999 585 595
32. E.D. Rosen, P. Sarraf, and A.E. Troy PPARγ is required for the differentiation of adipose tissue in vivo and in vitro Mol. Cell 4 1999 611 617
33. N. Kubota, T. Terauchi, and H. Miki PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance Mol. Cell 4 1999 597 609
34. E.D. Rosen, C.-H. Hsu, and X. Wang C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway Genes Dev. 16 2002 22 26
35. J. Auwerx PPARγ, the ultimate thrifty gene Diabetologia 42 1999 1033 1049
36. P.K. Harris, and R.F. Kletzien Localization of a pioglitazone response element in the adipocyte fatty acid-binding protein gene Mol. Pharmacol. 45 1994 439 445
37. B.M. Forman, P. Tontonoz, J. Chen, R.P. Brun, B.M. Spiegelman, and R.M. Evans 15-Deoxy, delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83 1995 803 812
38. S.A. Kliewer, J.M. Lenhard, T.M. Willson, I. Patel, D.C. Morris, and J.M. Lehmann A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation Cell 83 1995 813 819
39. D.S. Straus, G. Pascual, and M. Li 15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway Proc. Natl. Acad. Sci. USA 97 2000 4844 4849
40. A. Rossi, P. Kapahi, and G. Natoli Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase Nature 403 2000 103 108
41. L.C. Bell-Parikh, T. Ide, J.A. Lawson, P. McNamara, M. Reilly, and G.A. FitzGerald Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma J. Clin. Invest. 112 2003 945 955
42. I. Tzameli, H. Fang, and M. Ollero Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes J. Biol. Chem. 279 2004 36093 36102
43. R.R. Henry Thiazolidinediones Endocrinol. Metab. Clin. North Am. 26 1997 553 573
44. J.M. Olefsky, and A.R. Saltiel PPAR gamma and the treatment of insulin resistance Trends Endocrinol. Metab. 11 2000 362 368
45. T.M. Willson, J.E. Cobb, and D.J. Cowan The structure-activity relationship between peroxisome proliferator-activated receptor γ and the antihyperglycemic activity of thiazolidinediones J. Med. Chem. 39 1996 665 668
46. J. Berger, M.D. Leibowitz, and T.W. Doebber Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPAR delta ligands produce distinct biological effects J. Biol. Chem. 274 1999 6718 6725
47. R. Mukherjee, P.J. Davies, and D.L. Crombie Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists Nature 386 1997 407 410
48. D. Altshuler, J.N. Hirschhorn, and M. Klannemark The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat. Genet. 26 2000 76 80
49. I. Barroso, M. Gurnell, and V.E. Crowley Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus, and hypertension Nature 402 1999 880 883
50. S.M. Rangwala, B. Rhoades, and J.S. Shapiro Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity Dev. Cell 5 2003 657 663
51. N. Kubota, Y. Terauchi, and H. Miki PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance Mol. Cell 4 1999 597 609
52. P.D. Miles, Y. Barak, W. He, R.M. Evans, and J.M. Olefsky Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency J. Clin. Invest. 105 2000 287 292
53. T. Yamauchi, J. Kamon, and H. Waki The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance J. Biol. Chem. 276 2001 41245 41254
54. S.E. Inzucchi, D.G. Maggs, and G.R. Spollett Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus N. Engl. J. Med. 338 1998 867 872
55. L. Chao, B. Marcus-Samuels, and M.M. Mason Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones J. Clin. Invest. 106 2000 1221 1228
56. A.L. Hevener, W. He, and Y. Barak Muscle-specific Pparg deletion causes insulin resistance Nat. Med. 9 2003 1491 1497
57. A.W. Norris, L. Chen, and S.J. Fisher Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones J. Clin. Invest. 112 2003 608 618
58. C.M. Steppan, and M.A. Lazar Resistin and obesity-associated insulin resistance Trends Endocrinol. Metab. 13 2002 18 23
59. Y. Miyazaki, L. Glass, and C. Triplitt Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients Diabetologia 44 2001 2210 2219
60. S. Kumar, A.J. Boulton, and H. Beck-Nielsen Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Troglitazone Study Group Diabetologia 39 1996 701 709 [published erratum appears in Diabetologia 1996 October; 39 (10) 1245]
61. R.L. Chaiken, M. Eckert-Norton, and R. Pasmantier Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects Diabetologia 38 1995 1307 1312
62. G. Boden, and G.I. Shulman Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction Eur. J. Clin. Invest. 32 Suppl 3 2002 14 23
63. B.I. Frohnert, T.Y. Hui, and D.A. Bernlohr Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene J. Biol. Chem. 274 1999 3970 3977
64. K. Schoonjans, J. Peinado-Onsurbe, and A.M. Lefebvre PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene EMBO J. 15 1996 5336 5348
65. J. Tordjman, G. Chauvet, J. Quette, E.G. Beale, C. Forest, and B. Antoine Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells J. Biol. Chem. 278 2003 18785 18790
66. P. Tontonoz, E. Hu, J. Devine, E.G. Beale, and B.M. Spiegelman PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene Mol. Cell. Biol. 15 1995 351 357
67. H.P. Guan, Y. Li, M.V. Jensen, C.B. Newgard, C.M. Steppan, and M.A. Lazar A futile metabolic cycle activated in adipocytes by antidiabetic agents Nat. Med. 8 2002 1122 1128