Current development of mTOR inhibitors as anticancer agents

Nature Reviews Drug Discovery

Volumn 5, Issue 8, 2006, Pages 671-688

  Faivre, Sandrine ^a   Kroemer, Guido ^b   Raymond, Eric ^a  

^a BEAUJON HOSPITAL   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; AP 23573; CARBAMAZEPINE; CYCLIN D1; CYCLOSPORIN; DNA; EVEROLIMUS; FLUOROURACIL; GEFITINIB; GEMCITABINE; IMATINIB; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHENOBARBITAL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; RAPAMYCIN DERIVATIVE; RITUXIMAB; RNA; STEROID; TAMOXIFEN; TEMOZOLOMIDE; TEMSIROLIMUS; TRASTUZUMAB; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER HORMONE THERAPY; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CELL CYCLE PROGRESSION; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DISEASE MARKER; DOSE RESPONSE; DOWNSTREAM PROCESSING; DRUG DESIGN; DRUG EFFICACY; DRUG ERUPTION; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SAFETY; DRUG SENSITIVITY; DRUG TARGETING; ENDOMETRIUM CANCER; ENZYME ACTIVITY; GENE ACTIVATION; GLIOBLASTOMA; HERPES; HUMAN; KIDNEY CARCINOMA; LOW DRUG DOSE; MACULOPAPULAR RASH; MANTLE CELL LYMPHOMA; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; NAIL DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR VASCULARIZATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; EPIGENESIS, GENETIC; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOPROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 33746637660     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2062     Document Type: Review

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