Phosphatidic Acid Regulates Systemic Inflammatory Responses by Modulating the Akt-Mammalian Target of Rapamycin-p70 S6 Kinase 1 Pathway

Journal of Biological Chemistry

Volumn 278, Issue 46, 2003, Pages 45117-45127

  Lim, Hyung Kyu ^a,b   Choi, Young Ae ^a   Park, Wan ^b   Lee, Taehoon ^c   Ryu, Sung Ho ^c   Kim, Seong Yong ^a   Kim, Jae Ryong ^a   Kim, Jung Hye ^a   Baek, Suk Hwan ^a  

^a Yeungnam University College of Medicine   (South Korea)

^b Kyungpook National University   (South Korea)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BODY FLUIDS; CELLS; IMMUNOLOGY; METABOLITES; NITROGEN OXIDES; ORGANIC ACIDS; PHOSPHOLIPIDS;

INFLAMMATORY RESPONSES;

ENZYMES;

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHOSPHATIDIC ACID; PROSTAGLANDIN E2; PROTEIN KINASE B; RAPAMYCIN P70 S6 KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNE SYSTEM; INFLAMMATION; MACROPHAGE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RECEPTOR BINDING; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; ISOENZYMES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MAMMALIA;

EID: 0242496906     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303789200     Document Type: Article

References (60)

1. Hoffmann, J. A., Kafatos, F. C., Janeway, C. A., and Ezekowitz, R. A. (1999) Science 284, 1313-1318
2. Aderem, A., and Underhill, D. M. (1999) Annu. Rev. Immunol. 17, 593-623
3. Parrillo, J. E. (1993) N. Engl. J. Med. 328, 1471-1477
4. Ulevitch, R. J., and Tobias, P. S. (1999) Curr. Opin. Immunol. 11, 19-22
5. Bozza, M., Satoskar, A. R., Lin, G., Lu, B., Humbles, A. A., Gerard, C., and David, J. R. (1999) J. Exp. Med. 189, 341-346
6. Andersson, U., Wang, H., Palmblad, K., Aveberger, A., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., and Tracey, K. J. (2000) J. Exp. Med. 192, 565-570
7. Szabo, C. (1998) Ann. N. Y. Acad. Sci. 851, 422-425
8. Uematsu S., Matsumoto, M., Takeda, K., and Akira, S. (2002) J. Immunol. 168, 5811-5816
9. Choi, W. S., Chahdi, A., Kim, Y. M., Fraundorfer, P. F., and Beaven, M. A. (2002) Ann. N. Y. Acad. Sci. 968, 198-212
10. Shen, Y., Xu, L., and Foster, D. A. (2001) Mol. Cell Biol. 21, 595-602
11. McPhail, L. C., Qualliotine-Mann, D., and Waite, K. A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7931-7935
12. Exton, J. H. (1997) Physiol. Rev. 77, 303-320
13. Morris, A. J., Engebrecht, J., and Frohman, M. A. (1996) Trends Pharmacol. Sci. 17, 182-185
14. Rizzo, M. A., Shome, K., Vasudevan, C., Stolz, D. B., Sung, T. C., Frohman, M. A., Watkins, S. C., and Romero, G. (1999) J. Biol. Chem. 274, 1131-1139
15. Sergeant, S., Waite, K. A., Heravi, J., and McPhail, L. C. (2001) J. Biol. Chem. 276, 4737-4746
16. Moritz, A., De Graan, P. N., Gispen, W. H., and Wirtz, K. W. (1992) J. Biol. Chem. 267, 7207-7210
17. Olivera, A., Rosenthal, J., and Spiegel, S. (1996) J. Cell Biochem. 60, 529-537
18. Kusner, D. J., Hall, C. F., and Jackson, S. (1999) J. Immunol. 162, 2266-2274
19. Bandyopadhyay, R., and Basu, M. K. (2000) Mol. Cell Biochem. 203, 127-133
20. Rice, G. C., Brown, P. A., Nelson, R. J., Bianco, J. A., Singer, J. W., and Bursten, S. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3857-3861
21. Zhang, F., Zhao, G., and Dong, Z. (2001) Int. Immunopharmacol. 1, 1375-1384
22. Gingras, A. C., Raught, B., and Sonenberg, N. (2001) Genes Dev. 15, 807-826
23. Gingras, A. C., Raught, B., and Sonenberg, N. (1999) Annu. Rev. Biochem. 68, 913-963
24. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., and Schreiber, S. L. (1995) Nature 377, 441-446
25. Sekulic, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M., and Abraham, R. T. (2000) Cancer Res. 60, 3504-3513
26. Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., and Chen, J. (2001) Science 294, 1942-1945
27. Fukami, K., and Takenawa, T. (1992) J. Biol. Chem. 267, 10988-10993
28. Reeves, H. L., Thompson, M. G., Dack, C. L., Burt, A. D., and Day, C. P. (2000) Hepatology 31, 95-100
29. Park, D. W., Kim, J. R., Kim, S. Y., Sonn, J. K., Bang, O. S., Kang, S. S., Kim, J. H., and Baek, S. H. (2003) J. Immunol. 170, 2093-2099
30. Medzhitov, R., and Janeway, C. (2000) N. Engl. J. Med. 343, 338-344
31. Beutler, B. (2000) Curr. Opin. Microbiol. 3, 23-28
32. Glauser, M. P., Zanetti, G., Baumgartner, J. D., and Cohen, J. (1991) Lancet 338, 732-736
33. Pugin, J., Ulevitch, R. J., and Tobias, P. S. (1993) J. Exp. Med. 178, 2193-2200
34. Aderem, A., and Ulevitch, R. J. (2000) Nature 406, 782-787
35. Castrillo, A., Pennington, D. J., Otto, F., Parker, P. J., Owen, M. J., and Bosca, L. (2001) J. Exp. Med. 194, 1231-1242
36. Meng, F., and Lowell, C. A. (1997) J. Exp. Med. 185, 1661-1670
37. Nakagawa, R., Naka, T., Tsutsui, H., Fujimoto, M., Kimura, A., Abe, T., Seki, E., Sato, S., Takeuchi, O., Takeda, K., Akira, S., Yamanishi, K., Kawase, I., Nakanishi, K., and Kishimoto, T. (2002) Immunity 17, 677-687
38. Guha, M., and Mackman, N. (2002) J. Biol. Chem. 277, 32124-32132
39. Abraham, E., Bursten, S., Shenkar, R., Allbee, J., Tuder, R., Woodson, P., Guidot, D. M., Rice, G., Singer, J. W., and Repine, J. E. (1995) J. Exp. Med. 181, 569-575
40. Rice, G. C., Rosen, J., Weeks, R., Michnick, J., Bursten, S., Bianco, J. A., and Singer, J. W. (1994) Shock 1, 254-266
41. Cummings, R. J., Parinandi, N. L., Zaiman, A., Wang, L., Usatyuk, P. V., Garcia, J. G., and Natarajan, V. (2002) J. Biol. Chem. 277, 30227-30235
42. Wang, L., Cummings, R., Usatyuk P., Morris, A., Irani, K., and Natarajan, V. (2002) Biochem. J. 367, 751-760
43. Hasegawa, N., Oka, Y., Nakayama, M., Berry, G. J., Bursten, S., Rice, G., and Raffin, T. A. (1997) Am. J. Respir. Crit. Care Med. 155, 928-936
44. Rizzo, M., and Romero, G. (2002) Pharmacol. Ther. 94, 35-50
45. Jenkins, G. H., Fisette, P. L., and Anderson, R. A. (1994) J. Biol. Chem. 269, 11547-11554
46. Monick, M. M., Carter, A. B., Robeff, P. K., Flaherty, D. M., Peterson, M. W., and Hunninghake, G. W. (2001) J. Immunol. 166, 4713-4720
47. Coutant, A., Rescan, C., Gilot, D., Loyer, P., Gugune-Guillouzo, C., and Baffet, G. (2002) Hepatology 36, 1079-1088
48. Gonzalez-Garcia, A., Garrido, E., Hernandez, C., Alvarez, B., Jimenez, C., Cantrell, D. A., Pullen, N., and Carrera, A. C. (2002) J. Biol. Chem. 277, 1500-1508
49. Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., and Glass, D. J. (2001) Nat. Cell Biol. 3, 1009-1013
50. Schmelzle, T., and Hall, M. N. (2000) Cell 103, 253-262
51. Dinarello, C. A. (2000) Chest 118, 503-508
52. Zhang, X., and Morrison, D. C. (1993) J. Exp. Med. 177, 511-516
53. Higgins, G. C., Foster, J. L., and Postlethwaite, A. E. (1994) J. Exp. Med. 180, 607-614
54. Cross, M. J., Roberts, S., Ridley, A. J., Hodgkin, M. N., Stewart, A., Claesson-Welsh, L., and Wakelam, M. J. (1996) Curr. Biol. 6, 588-597
55. Kim, Y., Han, J. M., Han, B. R., Lee, K. A., Kim, J. H., Lee, B. D., Jang, I. H., Suh, P. G., and Ryu, S. H. (2000) J. Biol. Chem. 275, 13621-13627
56. Kim, J. H., Lee, S., Kim, J. H., Lee, T. G., Hirata, M., Suh, P. G., and Ryu, S. H. (2002) Biochemistry 41, 3414-3421
57. Hammond, S. M., Altshuller, Y. M., Sung, T. C., Rudge, S. A., Rose, K., Engebresht, J., Morris A. J., and Frohman, M. A. (1995) J. Biol. Chem. 270, 29640-29643
58. Lopez, I., Arnold, R. S., and Lambeth, J. D. (1998) J. Biol. Chem. 273, 12846-12852
59. Potter, M. W., Shah, S. A., Elbirt, K. K., and Callery, M. P. (2001) J. Surg. Res. 97, 54-59
60. Weinstein, S. L., Finn, A. J., Dave, S. H., Meng, F., Lowell, C. A., Sanghera, J. S., and DeFranco, A. L. (2000) J. Leukocyte Biol. 67, 405-414