-
1
-
-
0033544957
-
Translational regulation of ribonucleotide reductase by eukaryotic initiation factor 4E links protein synthesis to the control of DNA replication
-
Abid M.R., Li Y., Anthony C., De Benedetti A. Translational regulation of ribonucleotide reductase by eukaryotic initiation factor 4E links protein synthesis to the control of DNA replication. J. Biol. Chem. 274:1999;35991-35998
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35991-35998
-
-
Abid, M.R.1
Li, Y.2
Anthony, C.3
De Benedetti, A.4
-
2
-
-
2942544833
-
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
-
this issue
-
Avdulov S., Li S., Michalek V., Berrichter D., Peterson M., Perlman D., Manivel J.C., Sonenberg N., Yee D., Bitterman P.B., Polunovsky V.A. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell. 5:2004;. this issue
-
(2004)
Cancer Cell
, vol.5
-
-
Avdulov, S.1
Li, S.2
Michalek, V.3
Berrichter, D.4
Peterson, M.5
Perlman, D.6
Manivel, J.C.7
Sonenberg, N.8
Yee, D.9
Bitterman, P.B.10
Polunovsky, V.A.11
-
3
-
-
0037051093
-
Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma
-
Bauer C., Brass N., Diesinger I., Kayser K., Grasser F.A., Meese E. Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma. Int. J. Cancer. 98:2002;181-185
-
(2002)
Int. J. Cancer
, vol.98
, pp. 181-185
-
-
Bauer, C.1
Brass, N.2
Diesinger, I.3
Kayser, K.4
Grasser, F.A.5
Meese, E.6
-
4
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti M.-A., Houghton P.J. The TOR pathway. A target for cancer therapy Nat. Cancer Rev. 4:2004;335-348
-
(2004)
Nat. Cancer Rev.
, vol.4
, pp. 335-348
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
5
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas J.B., Vazquez F., Reddy A., Sellers W.R., Kaelin W.G. Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 4:2003;147-158
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr., W.G.5
-
6
-
-
0033615051
-
Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E: Evidence for internal ribosome repositioning in the human c-myc 5′UTR
-
Carter P.S., Jarquin-Pardo M., De Benedetti A. Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E. evidence for internal ribosome repositioning in the human c-myc 5′UTR Oncogene. 18:1999;4326-4335
-
(1999)
Oncogene
, vol.18
, pp. 4326-4335
-
-
Carter, P.S.1
Jarquin-Pardo, M.2
De Benedetti, A.3
-
7
-
-
0037423223
-
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
-
Chabes A., Georgieva B., Domkin V., Zhao X., Rothstein R., Thelander L. Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell. 112:2003;391-401
-
(2003)
Cell
, vol.112
, pp. 391-401
-
-
Chabes, A.1
Georgieva, B.2
Domkin, V.3
Zhao, X.4
Rothstein, R.5
Thelander, L.6
-
9
-
-
0033044355
-
EIF4E expression in tumors: Its possible role in progression of malignancies
-
De Benedetti A., Harris A.L. eIF4E expression in tumors. Its possible role in progression of malignancies Int. J. Biochem. Cell Biol. 31:1999;59-72
-
(1999)
Int. J. Biochem. Cell Biol.
, vol.31
, pp. 59-72
-
-
De Benedetti, A.1
Harris, A.L.2
-
10
-
-
0037134480
-
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin
-
Dilling M.B., Germain G.S., Dudkin L., Jayaraman A.L., Zhang X., Harwood F.C., Houghton P.J. 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. J. Biol. Chem. 277:2002;13907-13917
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13907-13917
-
-
Dilling, M.B.1
Germain, G.S.2
Dudkin, L.3
Jayaraman, A.L.4
Zhang, X.5
Harwood, F.C.6
Houghton, P.J.7
-
11
-
-
0344322474
-
AKT activity determines sensitivity to mTOR inhibitors by regulating cyclin D1 and c-myc expression
-
Gera J.F., Mellinghoff I.K., Shi Y., Rettig M.B., Tran C., Hsu J.H., Sawyers C.L., Lichtenstein A.K. AKT activity determines sensitivity to mTOR inhibitors by regulating cyclin D1 and c-myc expression. J. Biol. Chem. 23:2003;23
-
(2003)
J. Biol. Chem.
, vol.23
, pp. 23
-
-
Gera, J.F.1
Mellinghoff, I.K.2
Shi, Y.3
Rettig, M.B.4
Tran, C.5
Hsu, J.H.6
Sawyers, C.L.7
Lichtenstein, A.K.8
-
12
-
-
0028897627
-
Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts
-
Graff J.R., Boghaert E.R., De Benedetti A., Tudor D.L., Zimmer C.C., Chan S.K., Zimmer S.G. Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts. Int. J. Cancer. 60:1995;255-263
-
(1995)
Int. J. Cancer
, vol.60
, pp. 255-263
-
-
Graff, J.R.1
Boghaert, E.R.2
De Benedetti, A.3
Tudor, D.L.4
Zimmer, C.C.5
Chan, S.K.6
Zimmer, S.G.7
-
13
-
-
0029560416
-
A novel approach for expression cloning of small GTPases: Identification, tissue distribution and chromosome mapping of the human homolog of rheb
-
Gromov P.S., Madsen P., Tomerup N., Celis J.E. A novel approach for expression cloning of small GTPases. identification, tissue distribution and chromosome mapping of the human homolog of rheb FEBS Lett. 377:1995;221-226
-
(1995)
FEBS Lett.
, vol.377
, pp. 221-226
-
-
Gromov, P.S.1
Madsen, P.2
Tomerup, N.3
Celis, J.E.4
-
15
-
-
0031755688
-
Studies on the mechanism of resistance to rapamycin in human cancer cells
-
Hosoi H., Dilling M.B., Liu L.N., Danks M.K., Shikata T., Sekulic A., Abraham R.T., Lawrence J.C.J., Houghton P.J. Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol. Pharmacol. 54:1998;815-824
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 815-824
-
-
Hosoi, H.1
Dilling, M.B.2
Liu, L.N.3
Danks, M.K.4
Shikata, T.5
Sekulic, A.6
Abraham, R.T.7
Lawrence, J.C.J.8
Houghton, P.J.9
-
16
-
-
0033557578
-
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
-
Hosoi H., Dilling M.B., Shikata T., Liu L.N., Shu L., Ashmun R.A., Germain G.S., Abraham R.T., Houghton P.J. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 59:1999;886-894
-
(1999)
Cancer Res.
, vol.59
, pp. 886-894
-
-
Hosoi, H.1
Dilling, M.B.2
Shikata, T.3
Liu, L.N.4
Shu, L.5
Ashmun, R.A.6
Germain, G.S.7
Abraham, R.T.8
Houghton, P.J.9
-
17
-
-
0038094504
-
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)
-
Huang S., Shu L., Dilling M.B., Easton J., Harwood F.C., Ichijo H., Houghton P.J. Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol. Cell. 11:2003;1491-1501
-
(2003)
Mol. Cell
, vol.11
, pp. 1491-1501
-
-
Huang, S.1
Shu, L.2
Dilling, M.B.3
Easton, J.4
Harwood, F.C.5
Ichijo, H.6
Houghton, P.J.7
-
18
-
-
2942515128
-
Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells
-
Jiang H., Coleman J., Miskimins R., Miskimins W.K. Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells. Cancer Cell Int. 3:2003;2
-
(2003)
Cancer Cell Int.
, vol.3
, pp. 2
-
-
Jiang, H.1
Coleman, J.2
Miskimins, R.3
Miskimins, W.K.4
-
19
-
-
0026583874
-
The mRNA 5′ cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
-
Lazaris-Karatzas A., Sonenberg N. The mRNA 5′ cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Mol. Cell. Biol. 12:1992;1234-1238
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 1234-1238
-
-
Lazaris-Karatzas, A.1
Sonenberg, N.2
-
20
-
-
0026784679
-
Ras mediates translation initiation factor 4E-induced malignant transformation
-
Lazaris-Karatzas A., Smith M.R., Frederickson R.M., Jaramillo M.L., Liu Y.L., Kung H.F., Sonenberg N. Ras mediates translation initiation factor 4E-induced malignant transformation. Genes Dev. 6:1992;1631-1642
-
(1992)
Genes Dev.
, vol.6
, pp. 1631-1642
-
-
Lazaris-Karatzas, A.1
Smith, M.R.2
Frederickson, R.M.3
Jaramillo, M.L.4
Liu, Y.L.5
Kung, H.F.6
Sonenberg, N.7
-
21
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
Luo J., Manning B.D., Cantley L.C. Targeting the PI3K-Akt pathway in human cancer. Rationale and promise Cancer Cell. 4:2003;257-262
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
22
-
-
0029070762
-
Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines
-
Miyagi Y., Sugiyama A., Asai A., Okazaki T., Kuchino Y., Kerr S.J. Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines. Cancer Lett. 91:1995;247-252
-
(1995)
Cancer Lett.
, vol.91
, pp. 247-252
-
-
Miyagi, Y.1
Sugiyama, A.2
Asai, A.3
Okazaki, T.4
Kuchino, Y.5
Kerr, S.J.6
-
23
-
-
0141679203
-
Involvement of the Akt/mTOR pathway on EGF-induced cell transformation
-
Nomura M., He Z., Koyama I., Ma W.Y., Miyamoto K., Dong Z. Involvement of the Akt/mTOR pathway on EGF-induced cell transformation. Mol. Carcinog. 38:2003;25-32
-
(2003)
Mol. Carcinog.
, vol.38
, pp. 25-32
-
-
Nomura, M.1
He, Z.2
Koyama, I.3
Ma, W.Y.4
Miyamoto, K.5
Dong, Z.6
-
24
-
-
0027362742
-
Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts
-
Rinker-Schaeffer C.W., Graff J.R., De Benedetti A., Zimmer S.G., Rhoads R.E. Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts. Int. J. Cancer. 55:1993;841-847
-
(1993)
Int. J. Cancer
, vol.55
, pp. 841-847
-
-
Rinker-Schaeffer, C.W.1
Graff, J.R.2
De Benedetti, A.3
Zimmer, S.G.4
Rhoads, R.E.5
-
25
-
-
0029873363
-
Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells
-
Rosenwald I.B. Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells. Cancer Lett. 102:1996;113-123
-
(1996)
Cancer Lett.
, vol.102
, pp. 113-123
-
-
Rosenwald, I.B.1
-
26
-
-
2442648845
-
The translation factor eIF4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
Ruggero D., Montanaro L., Ma L., Xu W., Londei P., Cordon-Cardo C., Pandolfi P.P. The translation factor eIF4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat. Med. 10:2004;484-486
-
(2004)
Nat. Med.
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
Xu, W.4
Londei, P.5
Cordon-Cardo, C.6
Pandolfi, P.P.7
-
27
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
28
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker H., Radimerski T., Schindelholz B., Wittwer F., Belawat P., Daram P., Breuer S., Thomas G., Hafen E. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5:2003;559-565
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
29
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:2003;1259-1268
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
30
-
-
0037415692
-
The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth
-
Topisirovic I., Culjkovic B., Cohen N., Perez J.M., Skrabanek L., Borden K.L. The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. EMBO J. 22:2003;689-703
-
(2003)
EMBO J.
, vol.22
, pp. 689-703
-
-
Topisirovic, I.1
Culjkovic, B.2
Cohen, N.3
Perez, J.M.4
Skrabanek, L.5
Borden, K.L.6
-
31
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I., Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer. 2:2002;489-501
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
32
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
Wendel H.-G., de Stanchina E., Fridman J.S., Malina A., Ray S., Kogan S., Cordon-Cardo C., Pelletier J., Lowe S.W. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. 428:2004;332-337
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.-G.1
De Stanchina, E.2
Fridman, J.S.3
Malina, A.4
Ray, S.5
Kogan, S.6
Cordon-Cardo, C.7
Pelletier, J.8
Lowe, S.W.9
-
33
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A., Johnstone S.R., Dickerson K., Leiper F.C., Fryer L.G., Neumann D., Schlattner U., Wallimann T., Carlson M., Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13:2003;2004-2008
-
(2003)
Curr. Biol.
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
34
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang Y., Gao X., Saucedo L.J., Ru B., Edgar B.A., Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5:2003;578-581
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
|