Renewing the conspiracy theory debate: Does Raf function alone to mediate Ras oncogenesis?

Trends in Cell Biology

Volumn 14, Issue 11, 2004, Pages 639-647

  Repasky, Gretchen A ^a   Chenette, Emily J ^b   Der, Channing J ^b,c  

^a Department of Psychology   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAL PROTEIN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN;

BINDING AFFINITY; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; ENZYME ACTIVITY; FIBROBLAST; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; HYDROLYSIS; METASTASIS; MORPHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; GENES, RAS; HUMANS; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION;

EID: 7444245100     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2004.09.014     Document Type: Review

References (86)

1. J. Shields Understanding Ras: 'it ain't over 'til it's over' Trends Cell Biol. 10 2000 147 154
2. L. Feig, and R. Buchsbaum Cell signaling: life or death decisions of ras proteins Curr. Biol. 12 2002 R259 R261
3. L. Feig Ral-GTPases: approaching their 15 minutes of fame Trends Cell Biol. 13 2003 419 425
4. A. Cox, and C. Der The dark side of ras: regulation of apoptosis Oncogene 22 2003 8999 9006
5. C. Herrmann Ras-effector interactions: after one decade Curr. Opin. Struct. Biol. 13 2003 122 129
6. H. Chong Mechanisms of regulating the Raf kinase family Cell. Signal. 15 2003 463 469
7. A. Arcaro The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils J. Biol. Chem. 273 1998 805 813
8. C. Ponting, and D. Benjamin A novel family of Ras-binding domains Trends Biochem. Sci. 21 1996 422 425
9. G. Kalhammer Ras-binding domains: predicting function versus folding FEBS Lett. 414 1997 599 602
10. Y. Liao RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans J. Biol. Chem. 274 1999 37815 37820
11. P. Rodriguez-Viciana Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate Mol. Cell. Biol. 24 2004 4943 4954
12. A. Bernards, and J. Settleman GAP control: regulating the regulators of small GTPases Trends Cell Biol. 14 2004 377 385
13. S. Matheny Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP Nature 427 2004 256 260
14. D. Tuveson Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects Cancer Cell 5 2004 375 387
15. K. Mercer, and C. Pritchard Raf proteins and cancer: B-Raf is identified as a mutational target Biochim. Biophys. Acta 1653 2003 25 40
16. C. Wellbrock V599EB-RAF is an oncogene in melanocytes Cancer Res. 64 2004 2338 2342
17. H. Davies Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
18. P. Wan Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell 116 2004 855 867
19. H. Rajagopalan Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status Nature 418 2002 934
20. M. Vos The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung J. Biol. Chem. 278 2003 21938 21943
21. G. Singer Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma J. Natl. Cancer Inst. 95 2003 484 486
22. N. Sieben In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours J. Pathol. 202 2004 336 340
23. H. Tsao Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma J. Invest. Dermatol. 122 2004 337 341
24. N. Ishimura BRAF and K-ras gene mutations in human pancreatic cancers Cancer Lett. 199 2003 169 173
25. E. Calhoun BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets Am. J. Pathol. 163 2003 1255 1260
26. M. Gemignani Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma Gynecol. Oncol. 90 2003 378 381
27. S. Oldham Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells Proc. Natl. Acad. Sci. U. S. A. 93 1996 6924 6928
28. A. Schulze Analysis of the transcriptional program induced by Raf in epithelial cells Genes Dev. 15 2001 981 994
29. N. Hamad Distinct requirements for Ras oncogenesis in human versus mouse cells Genes Dev. 16 2002 2045 2057
30. G. Pearson Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation J. Biol. Chem. 275 2000 37303 37306
31. I. Vivanco, and C. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
32. Y. Samuels High frequency of mutations of the PIK3CA gene in human cancers Science 304 2004 554
33. A. McFall Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase Mol. Cell. Biol. 21 2001 5488 5499
34. A. Ulku Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells Mol. Cancer Res. 1 2003 1077 1088
35. B. Boettner, and L. Van Aelst The RASputin effect Genes Dev. 16 2002 2033 2038
36. R. Wolthuis Stimulation of gene induction and cell growth by the Ras effector Rlf EMBO J. 16 1997 6748 6761
37. T. Urano Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation EMBO J. 15 1996 810 816
38. M. White A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation J. Biol. Chem. 271 1996 16439 16442
39. Y. Ward Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways Mol. Cell. Biol. 21 2001 5958 5969
40. A. Rangarajan, and R. Weinberg Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice Nat. Rev. Cancer 3 2003 952 959
41. W. Hahn Creation of human tumour cells with defined genetic elements Nature 400 1999 464 468
42. M. White Multiple Ras functions can contribute to mammalian cell transformation Cell 80 1995 533 541
43. T. Joneson Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS Science 271 1996 810 812
44. R. Khosravi-Far Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation Mol. Cell. Biol. 16 1996 3923 3933
45. P. Rodriguez-Viciana Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras Cell 89 1997 457 467
46. L. Han Protein binding and signaling properties of RIN1 suggest a unique effector function Proc. Natl. Acad. Sci. U. S. A. 94 1997 4954 4959
47. G. Kelley Phospholipase Cε: a novel Ras effector EMBO J. 20 2001 743 754
48. Y. Chien, and M. White RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival EMBO Rep. 4 2003 800 806
49. M. Shipitsin, and L. Feig RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells Mol. Cell. Biol. 24 2004 5746 5756
50. D. Bar-Sagi, and A. Hall Ras and Rho GTPases: a family reunion Cell 103 2000 227 238
51. E. Sahai, and C. Marshall RHO-GTPases and cancer Nat. Rev. Cancer 2 2002 133 142
52. J. Lambert Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism Nat. Cell Biol. 4 2002 621 625
53. A. Malliri Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours Nature 417 2002 867 871
54. M. Rytomaa Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis Curr. Biol. 9 1999 1043 1046
55. M. Vos RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor J. Biol. Chem. 278 2003 28045 28051
56. S. Tommasi RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1 Oncogene 21 2002 2713 2720
57. J. Chen The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas Cancer Cell 4 2003 405 413
58. L. Hesson NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers Oncogene 22 2003 947 954
59. R. Dammann Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 Nat. Genet. 25 2000 315 319
60. D. Burbee Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression J. Natl. Cancer Inst. 93 2001 691 699
61. R. Dammann Hypermethylation of the CpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers Cancer Res. 61 2001 3105 3109
62. K. Lo High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma Cancer Res. 61 2001 3877 3881
63. K. Dreijerink The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis Proc. Natl. Acad. Sci. U. S. A. 98 2001 7504 7509
64. M. Lee Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma Cancer Res. 61 2001 6688 6692
65. D. Byun Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma Cancer Res. 61 2001 7034 7038
66. C. Morrissey Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma Cancer Res. 61 2001 7277 7281
67. J. Yoon Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas Int. J. Cancer 94 2001 212 217
68. Y. Aoyama Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases Oncogene 23 2004 3426 3433
69. M. Vos Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis J. Biol. Chem. 275 2000 35669 35672
70. S. Ortiz-Vega The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 Oncogene 21 2002 1381 1390
71. L. Shivakumar The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation Mol. Cell. Biol. 22 2002 4309 4318
72. J. Rebhun Identification of guanine nucleotide exchange factors for the Rap1 GTPase: regulation of MR-GEF by M-Ras-GTP interaction J. Biol. Chem. 275 2000 34901 34908
73. J. Downward Targeting RAS signalling pathways in cancer therapy Nat. Rev. Cancer 3 2003 11 22
74. S. Cantor Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases Mol. Cell. Biol. 15 1995 4578 4584
75. S. Park, and R. Weinberg A putative effector of Ral has homology to Rho/Rac GTPase activating proteins Oncogene 11 1995 2349 2355
76. V. Jullien-Flores Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity J. Biol. Chem. 270 1995 22473 22477
77. V. Jullien-Flores RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis J. Cell Sci. 113 2000 2837 2844
78. M. Ikeda Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral J. Biol. Chem. 273 1998 814 821
79. A. Yamaguchi An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1 J. Biol. Chem. 272 1997 31230 31234
80. Y. Ohta The small GTPase RalA targets filamin to induce filopodia Proc. Natl. Acad. Sci. U. S. A. 96 1999 2122 2128
81. L. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655 1657
82. S. Moskalenko Ral GTPases regulate exocyst assembly through dual subunit interactions J. Biol. Chem. 278 2003 51743 51748
83. N. de Ruiter Ras-dependent regulation of c-Jun phosphorylation is mediated by the ral guanine nucleotide exchange factor-Ral pathway Mol. Cell. Biol. 20 2000 8480 8488
84. D. Henry Ral GTPases contribute to regulation of cyclin D1 through activation of NF-κB Mol. Cell. Biol. 20 2000 8084 8092
85. T. Goi An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity EMBO J. 19 2000 623 630
86. N. de Ruiter Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451 Mol. Cell. Biol. 21 2001 8225 8235