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Volumn 15, Issue 2, 2011, Pages 505-521

Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; APOLIPOPROTEIN B100; CHAPERONE; ENDOTOXIN; INITIATION FACTOR 2ALPHA; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN IRE1; PROTEIN IRE1ALPHA; PROTEIN KINASE; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

EID: 79959507760     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3790     Document Type: Review
Times cited : (80)

References (195)
  • 5
    • 70349770695 scopus 로고    scopus 로고
    • Epidemiology and natural history of non-alcoholic steatohepatitis
    • Argo CK and Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis 13: 511-531, 2009.
    • (2009) Clin Liver Dis , vol.13 , pp. 511-531
    • Argo, C.K.1    Caldwell, S.H.2
  • 6
    • 15944425804 scopus 로고    scopus 로고
    • Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis
    • DOI 10.1016/j.freeradbiomed.2005.01.015
    • Aronis A, Madar Z, and Tirosh O. Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis. Free Radic Biol Med 38: 1221-1230, 2005. (Pubitemid 40445539)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.9 , pp. 1221-1230
    • Aronis, A.1    Madar, Z.2    Tirosh, O.3
  • 7
    • 35848940511 scopus 로고    scopus 로고
    • Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response
    • DOI 10.1089/ars.2007.1796
    • Bailey D and O'Hare P. Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response. Antioxid Redox Signal 9: 2305-2321, 2007. (Pubitemid 350059018)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.12 , pp. 2305-2321
    • Bailey, D.1    O'Hare, P.2
  • 9
    • 52749091008 scopus 로고    scopus 로고
    • Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
    • Boden G, Duan X, Homko C, Molina EJ, Song W, Perez O, Cheung P, and Merali S. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57: 2438-2444, 2008.
    • (2008) Diabetes , vol.57 , pp. 2438-2444
    • Boden, G.1    Duan, X.2    Homko, C.3    Molina, E.J.4    Song, W.5    Perez, O.6    Cheung, P.7    Merali, S.8
  • 10
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • DOI 10.1194/jlr.M600299-JLR200
    • Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, and Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res 47: 2726-2737, 2006. (Pubitemid 44936086)
    • (2006) Journal of Lipid Research , vol.47 , Issue.12 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5    Schaffer, J.E.6
  • 11
    • 0030698129 scopus 로고    scopus 로고
    • A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells
    • Brewer JW, Cleveland JL, and Hendershot LM. A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells. EMBO J 16: 7207-7216, 1997. (Pubitemid 27520818)
    • (1997) EMBO Journal , vol.16 , Issue.23 , pp. 7207-7216
    • Brewer, J.W.1    Cleveland, J.L.2    Hendershot, L.M.3
  • 13
    • 25844454854 scopus 로고    scopus 로고
    • Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis
    • DOI 10.2337/diabetes.54.10.2917
    • Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, and Biden TJ. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic B-cells from lipoapoptosis. Diabetes 54: 2917-2924, 2005. (Pubitemid 41401087)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2917-2924
    • Busch, A.K.1    Gurisik, E.2    Cordery, D.V.3    Sudlow, M.4    Denyer, G.S.5    Ross Laybutt, D.6    Hughes, W.E.7    Biden, T.J.8
  • 14
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • DOI 10.1038/nm1166
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, and Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat Med 11: 183-190, 2005. (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 15
    • 0032496279 scopus 로고    scopus 로고
    • Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to ApoB in the Sec61 complex
    • DOI 10.1074/jbc.273.19.11887
    • Chen Y, Le Caherec F, and Chuck SL. Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex. J Biol Chem 273: 11887-11894, 1998. (Pubitemid 28272096)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.19 , pp. 11887-11894
    • Chen, Y.1    Le Caherec, F.2    Chuck, S.L.3
  • 16
    • 0038142845 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An underrecognized cause of cryptogenic cirrhosis
    • DOI 10.1001/jama.289.22.3000
    • Clark JM and Diehl A. Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 289: 3000-3004, 2003. (Pubitemid 37430103)
    • (2003) Journal of the American Medical Association , vol.289 , Issue.22 , pp. 3000-3004
    • Clark, J.M.1    Diehl, A.M.2
  • 18
    • 0030879870 scopus 로고    scopus 로고
    • The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane
    • Cox JS, Chapman RE, and Walter P. The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Mol Biol Cell 8: 1805-1814, 1997. (Pubitemid 27411143)
    • (1997) Molecular Biology of the Cell , vol.8 , Issue.9 , pp. 1805-1814
    • Cox, J.S.1    Chapman, R.E.2    Walter, P.3
  • 19
    • 72649087136 scopus 로고    scopus 로고
    • Circadian clockcoordinated 12 hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver
    • Cretenet G, Le Clech M, and Gachon F. Circadian clockcoordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver. Cell Metab 11: 47-57, 2010.
    • (2010) Cell Metab , vol.11 , pp. 47-57
    • Cretenet, G.1    Le Clech, M.2    Gachon, F.3
  • 21
    • 29244462498 scopus 로고    scopus 로고
    • Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
    • DOI 10.1016/j.biocel.2005.09.018, PII S1357272505003055
    • Cullinan SB and Diehl JA. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol 38: 317-332, 2006. (Pubitemid 41821881)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.3 , pp. 317-332
    • Cullinan, S.B.1    Diehl, J.A.2
  • 23
    • 70349764468 scopus 로고    scopus 로고
    • Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis
    • Cusi K. Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis. Clin Liver Dis 13: 545-563, 2009.
    • (2009) Clin Liver Dis , vol.13 , pp. 545-563
    • Cusi, K.1
  • 24
    • 0037910211 scopus 로고    scopus 로고
    • The future of GI and liver research: Editorial perspectives III. JNK/AP-1 regulation of hepatocyte death
    • Czaja MJ. The future of GI and liver research: editorial perspectives III. JNK/AP-1 regulation of hepatocyte death. Am J Physiol Gastrointest Liver Physiol 284: G875-G879, 2002. (Pubitemid 36597328)
    • (2003) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.284
    • Czaja, M.J.1
  • 25
    • 58249093873 scopus 로고    scopus 로고
    • Induction of hepatitis by JNK-mediated expression of TNF-alpha
    • Das M, Sabio G, Jiang F, Rincon M, Flavell RA, and Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136: 249-260, 2009.
    • (2009) Cell , vol.136 , pp. 249-260
    • Das, M.1    Sabio, G.2    Jiang, F.3    Rincon, M.4    Flavell, R.A.5    Davis, R.J.6
  • 26
    • 52649173791 scopus 로고    scopus 로고
    • Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and palmitate-induced stress in human liver and adipose cell lines
    • Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, and Elbein SC. Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab 295: E393-E400, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Das, S.K.1    Chu, W.S.2    Mondal, A.K.3    Sharma, N.K.4    Kern, P.A.5    Rasouli, N.6    Elbein, S.C.7
  • 27
    • 77956828961 scopus 로고    scopus 로고
    • Distinct gene expression profiles characterize cellular responses to palmitate and oleate
    • Das SK, Mondal AK, and Elbein SC. Distinct gene expression profiles characterize cellular responses to palmitate and oleate. J Lipid Res 51: 2121-2131, 2010.
    • (2010) J Lipid Res , vol.51 , pp. 2121-2131
    • Das, S.K.1    Mondal, A.K.2    Elbein, S.C.3
  • 30
    • 38049155818 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
    • Deniaud A, Sharaf el dein O, Maillier E, Poncet D, Kroemer G, Lemaire C, and Brenner C. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27: 285-299, 2008.
    • (2008) Oncogene , vol.27 , pp. 285-299
    • Deniaud, A.1    Sharaf El Dein, O.2    Maillier, E.3    Poncet, D.4    Kroemer, G.5    Lemaire, C.6    Brenner, C.7
  • 31
    • 0344874201 scopus 로고    scopus 로고
    • Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
    • Diraison F, Moulin P, and Beylot M. Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab 29: 478-485, 2003. (Pubitemid 37474259)
    • (2003) Diabetes and Metabolism , vol.29 , Issue.5 , pp. 478-485
    • Diraison, F.1    Moulin, P.H.2    Beylot, M.3
  • 32
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • DOI 10.1172/JCI200523621
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, and Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115: 1343-1351, 2005. (Pubitemid 40629054)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 33
    • 0035898534 scopus 로고    scopus 로고
    • The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR
    • DOI 10.1093/emboj/20.14.3771
    • Donze O, Abbas-Terki T, and Picard D. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. EMBO J 20: 3771-3780, 2001. (Pubitemid 32691788)
    • (2001) EMBO Journal , vol.20 , Issue.14 , pp. 3771-3780
    • Donze, O.1    Abbas-Terki, T.2    Picard, D.3
  • 34
    • 1442264796 scopus 로고    scopus 로고
    • The protein kinase PKR: A molecular clock that sequentially activates survival and death programs
    • DOI 10.1038/sj.emboj.7600078
    • Donze O, Deng J, Curran J, Sladek R, Picard D, and Sonenberg N. The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. EMBO J 23: 564-571, 2004. (Pubitemid 38282388)
    • (2004) EMBO Journal , vol.23 , Issue.3 , pp. 564-571
    • Donze, O.1    Deng, J.2    Curran, J.3    Sladek, R.4    Picard, D.5    Sonenberg, N.6
  • 35
    • 51449107605 scopus 로고    scopus 로고
    • Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease
    • Elizondo A, Araya J, Rodrigo R, Signorini C, Sgherri C, Comporti M, Poniachik J, and Videla LA. Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease. Biol Res 41: 59-68, 2008.
    • (2008) Biol Res , vol.41 , pp. 59-68
    • Elizondo, A.1    Araya, J.2    Rodrigo, R.3    Signorini, C.4    Sgherri, C.5    Comporti, M.6    Poniachik, J.7    Videla, L.A.8
  • 36
    • 33845326443 scopus 로고    scopus 로고
    • Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment
    • Ersoz G, Gunsar F, Karasu Z, Akay S, Batur Y, and Akarca US. Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment. Turk J Gastroenterol 16: 124-128, 2005. (Pubitemid 44869965)
    • (2005) Turkish Journal of Gastroenterology , vol.16 , Issue.3 , pp. 124-128
    • Ersoz, G.1    Gunsar, F.2    Karasu, Z.3    Akay, S.4    Batur, Y.5    Akarca, U.S.6
  • 37
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • DOI 10.1002/hep.20410
    • Fassio E, Alvarez E, Dominguez N, Landeira G, and Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40: 820-826, 2004. (Pubitemid 39288114)
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 38
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
    • DOI 10.1016/S0016-5085(03)00907-7
    • Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, and Gores GJ. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125: 437-443, 2003. (Pubitemid 36929425)
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5    Lindor, K.D.6    Gores, G.J.7
  • 39
    • 0842269198 scopus 로고    scopus 로고
    • Hepatic steatosis in obese patients: Clinical aspects and prognostic significance
    • DOI 10.1111/j.1467-789X.2004.00126.x
    • Festi D, Colecchia A, Sacco T, Bondi M, Roda E, and Marchesini G. Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obes Rev 5: 27-42, 2004. (Pubitemid 38173592)
    • (2004) Obesity Reviews , vol.5 , Issue.1 , pp. 27-42
    • Festi, D.1    Colecchia, A.2    Sacco, T.3    Bondi, M.4    Roda, E.5    Marchesini, G.6
  • 42
    • 34250021317 scopus 로고    scopus 로고
    • Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro
    • DOI 10.1053/j.gastro.2007.03.033, PII S0016508507005574
    • Geisler F, Algul H, Paxian S, and Schmid RM. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 132: 2489-2503, 2007. (Pubitemid 46890861)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2489-2503
    • Geisler, F.1    Algul, H.2    Paxian, S.3    Schmid, R.M.4
  • 43
    • 33644683205 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and the metabolic syndrome: Effects of weight loss and a review of popular diets. Are low carbohydrate diets the answer?
    • Gill HK and Wu GY. Non-alcoholic fatty liver disease and the metabolic syndrome: effects of weight loss and a review of popular diets. Are low carbohydrate diets the answer? World J Gastroenterol 12: 345-353, 2006. (Pubitemid 43329249)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.3 , pp. 345-353
    • Gill, H.K.1    Wu, G.Y.2
  • 44
    • 70350459324 scopus 로고    scopus 로고
    • From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis
    • Glimcher LH and Lee AH. From sugar to fat: how the transcription factor XBP1 regulates hepatic lipogenesis. Ann N Y Acad Sci 1173 Suppl 1: E2-E9, 2009.
    • (2009) Ann N y Acad Sci , vol.1173 , Issue.SUPPL. 1
    • Glimcher, L.H.1    Lee, A.H.2
  • 46
    • 9644303176 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress
    • DOI 10.1074/jbc.C400261200
    • Gu F, Nguyen DT, Stuible M, Dube N, Tremblay ML, and Chevet E. Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem 279: 49689-49693, 2004. (Pubitemid 39577772)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.48 , pp. 49689-49693
    • Gu, F.1    Duc, T.N.2    Stuible, M.3    Dube, N.4    Tremblay, M.L.5    Chevet, E.6
  • 50
    • 69749123786 scopus 로고    scopus 로고
    • Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
    • Hetz C and Glimcher LH. Fine-tuning of the unfolded protein response: assembling the IRE1alpha interactome. Mol Cell 35: 551-561, 2009.
    • (2009) Mol Cell , vol.35 , pp. 551-561
    • Hetz, C.1    Glimcher, L.H.2
  • 52
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917, 2010.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 53
    • 0346880504 scopus 로고    scopus 로고
    • Inflammatory pathways and insulin action
    • DOI 10.1038/sj.ijo.0802502
    • Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 27 Suppl 3: S53-S55, 2003. (Pubitemid 38019190)
    • (2003) International Journal of Obesity , vol.27 , Issue.SUPPL. 3
    • Hotamisligil, G.S.1
  • 54
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kB activation and downregulation of TRAF2 expression
    • Hu P, Han Z, Couvillon AD, Kaufman RJ, and Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kB activation and downregulation of TRAF2 expression. Mol Cell Biol 26: 3071-3084, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 55
    • 40749083206 scopus 로고    scopus 로고
    • Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
    • DOI 10.1111/j.1440-1746.2007.05276.x
    • Ji C. Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol Hepatol 23 Suppl 1: S16-S24, 2008. (Pubitemid 351389024)
    • (2008) Journal of Gastroenterology and Hepatology , vol.23 , Issue.SUPPL. 1
    • Ji, C.1
  • 56
    • 0037960128 scopus 로고    scopus 로고
    • Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    • DOI 10.1016/S0016-5085(03)00276-2
    • Ji C and Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124: 1488-1499, 2003. (Pubitemid 36531821)
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1488-1499
    • Ji, C.1    Kaplowitz, N.2
  • 57
    • 33745890321 scopus 로고    scopus 로고
    • ER stress: Can the liver cope?
    • Ji C and Kaplowitz N. ER stress: can the liver cope? J Hepatol 45: 321-333, 2006.
    • (2006) J Hepatol , vol.45 , pp. 321-333
    • Ji, C.1    Kaplowitz, N.2
  • 59
    • 65349113758 scopus 로고    scopus 로고
    • IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans
    • Jo H, Shim J, Lee JH, Lee J, and Kim JB. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Cell Metab 9: 440-448, 2009.
    • (2009) Cell Metab , vol.9 , pp. 440-448
    • Jo, H.1    Shim, J.2    Lee, J.H.3    Lee, J.4    Kim, J.B.5
  • 61
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferre P, and Foufelle F. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119: 1201-1215, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3    Luquet, S.4    Magnan, C.5    Koike, T.6    Ferre, P.7    Foufelle, F.8
  • 62
    • 0036853914 scopus 로고    scopus 로고
    • Orchestrating the unfolded protein response in health and disease
    • DOI 10.1172/JCI200216886
    • Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398, 2002. (Pubitemid 35396907)
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.10 , pp. 1389-1398
    • Kaufman, R.J.1
  • 63
    • 0033562966 scopus 로고    scopus 로고
    • Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
    • Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233, 1999. (Pubitemid 29250189)
    • (1999) Genes and Development , vol.13 , Issue.10 , pp. 1211-1233
    • Kaufman, R.J.1
  • 65
    • 57049117856 scopus 로고    scopus 로고
    • Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities
    • Kim I, Xu W, and Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7: 1013-1030, 2008.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 1013-1030
    • Kim, I.1    Xu, W.2    Reed, J.C.3
  • 66
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • DOI 10.1038/nrm2245, PII NRM2245
    • Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8: 931-937, 2007. (Pubitemid 47622558)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.11 , pp. 931-937
    • Klionsky, D.J.1
  • 67
    • 42949178538 scopus 로고    scopus 로고
    • Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
    • DOI 10.1053/j.gastro.2008.01.075, PII S0016508508001819
    • Korenblat KM, Fabbrini E, Mohammed BS, and Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 134: 1369-1375, 2008. (Pubitemid 351615354)
    • (2008) Gastroenterology , vol.134 , Issue.5 , pp. 1369-1375
    • Korenblat, K.M.1    Fabbrini, E.2    Mohammed, B.S.3    Klein, S.4
  • 68
    • 7444255577 scopus 로고    scopus 로고
    • 2-terminal kinase
    • DOI 10.1158/0008-5472.CAN-04-1552
    • Kurinna SM, Tsao CC, Nica AF, Jiffar T, and Ruvolo PP. Ceramide promotes apoptosis in lung cancer-derived A549 cells by a mechanism involving c-Jun NH2-terminal kinase. Cancer Res 64: 7852-7856, 2004. (Pubitemid 39446918)
    • (2004) Cancer Research , vol.64 , Issue.21 , pp. 7852-7856
    • Kurinna, S.M.1    Chun, C.T.2    Nica, A.F.3    Jiffar, T.4    Ruvolo, P.P.5
  • 71
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • DOI 10.1126/science.1158042
    • Lee A-H, Scapa EF, Cohen DE, and Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496, 2008. (Pubitemid 351929428)
    • (2008) Science , vol.320 , Issue.5882 , pp. 1492-1496
    • Lee, A.-H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 72
    • 7244221504 scopus 로고    scopus 로고
    • Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1
    • DOI 10.1074/jbc.M408235200
    • Lee JN and Ye J. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J Biol Chem 279: 45257-45265, 2004. (Pubitemid 39430941)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 45257-45265
    • Lee, J.N.1    Ye, J.2
  • 73
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B and Kroemer G. Autophagy in the pathogenesis of disease. Cell 132: 27-42, 2008.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 74
    • 70349905357 scopus 로고    scopus 로고
    • Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
    • Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, and Tabas I. Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol 186: 783-792, 2009.
    • (2009) J Cell Biol , vol.186 , pp. 783-792
    • Li, G.1    Mongillo, M.2    Chin, K.T.3    Harding, H.4    Ron, D.5    Marks, A.R.6    Tabas, I.7
  • 75
    • 0041814595 scopus 로고    scopus 로고
    • PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver
    • DOI 10.1210/en.2003-0236
    • Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, and Cavener DR. PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology 144: 3505-3513, 2003. (Pubitemid 36904429)
    • (2003) Endocrinology , vol.144 , Issue.8 , pp. 3505-3513
    • Li, Y.1    Iida, K.2    O'Neil, J.3    Zhang, P.4    Li, S.5    Frank, A.6    Gabai, A.7    Zambito, F.8    Liang, S.-H.9    Rosen, C.J.10    Cavener, D.R.11
  • 76
    • 65549136260 scopus 로고    scopus 로고
    • Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: Role of stearoyl-coa desaturase
    • Li ZZ, Berk M, McIntyre TM, and Feldstein AE. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem 284: 5637-5644, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 5637-5644
    • Li, Z.Z.1    Berk, M.2    McIntyre, T.M.3    Feldstein, A.E.4
  • 79
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • Listenberger LL, Ory DS, and Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276: 14890-14895, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 80
    • 0036009411 scopus 로고    scopus 로고
    • NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
    • DOI 10.1053/jhep.2002.32534
    • Liu H, Lo CR, and Czaja MJ. NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology 35: 772-778, 2002. (Pubitemid 34258370)
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 772-778
    • Liu, H.1    Lo, C.R.2    Czaja, M.J.3
  • 82
    • 54449091729 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H
    • Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, and Duncan SA. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology 48: 1242-1250, 2008.
    • (2008) Hepatology , vol.48 , pp. 1242-1250
    • Luebke-Wheeler, J.1    Zhang, K.2    Battle, M.3    Si-Tayeb, K.4    Garrison, W.5    Chhinder, S.6    Li, J.7    Kaufman, R.J.8    Duncan, S.A.9
  • 83
    • 33846839443 scopus 로고    scopus 로고
    • Deletion of NEMO/IKKΨ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    • DOI 10.1016/j.ccr.2006.12.016, PII S1535610807000207
    • Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, and Pasparakis M. Deletion of NEMO/IKKΨ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 11: 119-132, 2007. (Pubitemid 46209851)
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 119-132
    • Luedde, T.1    Beraza, N.2    Kotsikoris, V.3    Van Loo, G.4    Nenci, A.5    De Vos, R.6    Roskams, T.7    Trautwein, C.8    Pasparakis, M.9
  • 84
    • 0036314984 scopus 로고    scopus 로고
    • Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
    • DOI 10.1016/S0022-2836(02)00234-6
    • Ma Y, Brewer JW, Diehl JA, and Hendershot LM. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318: 1351-1365, 2002. (Pubitemid 34754003)
    • (2002) Journal of Molecular Biology , vol.318 , Issue.5 , pp. 1351-1365
    • Ma, Y.1    Brewer, J.W.2    Alan Diehl, J.3    Hendershot, L.M.4
  • 85
    • 35848957485 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?
    • DOI 10.1089/ars.2007.1782
    • Malhotra JD and Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a doubleedged sword? Antioxid Redox Signal 9: 2277-2293, 2007. (Pubitemid 350059010)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.12 , pp. 2277-2293
    • Malhotra, J.D.1    Kaufman, R.J.2
  • 88
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • DOI 10.1152/physrev.00015.2006
    • Marciniak S and Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149, 2006. (Pubitemid 44521649)
    • (2006) Physiological Reviews , vol.86 , Issue.4 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 90
    • 21644475309 scopus 로고    scopus 로고
    • Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease. A double-blind, placebo-controlled trial
    • Mendez-Sanchez N, Gonzalez V, Chavez-Tapia N, Ramos MH, and Uribe M. Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease. A double-blind, placebo-controlled trial. Ann Hepatol 3: 108-112, 2004.
    • (2004) Ann Hepatol , vol.3 , pp. 108-112
    • Mendez-Sanchez, N.1    Gonzalez, V.2    Chavez-Tapia, N.3    Ramos, M.H.4    Uribe, M.5
  • 93
    • 72949111893 scopus 로고    scopus 로고
    • Physiological functions of autophagy
    • Mizushima N. Physiological functions of autophagy. Curr Top Microbiol Immunol 335: 71-84, 2009.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 71-84
    • Mizushima, N.1
  • 94
    • 27644493346 scopus 로고    scopus 로고
    • The pleiotropic role of autophagy: From protein metabolism to bactericide
    • DOI 10.1038/sj.cdd.4401728, PII 4401728
    • Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ 12 Suppl 2: 1535-1541, 2005. (Pubitemid 41553990)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.SUPPL. 2 , pp. 1535-1541
    • Mizushima, N.1
  • 95
    • 24944526652 scopus 로고    scopus 로고
    • Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro
    • DOI 10.1007/s00125-005-1861-9
    • Moffitt JH, Fielding BA, Evershed R, Berstan R, Currie JM, and Clark A. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 48: 1819-1829, 2005. (Pubitemid 41317836)
    • (2005) Diabetologia , vol.48 , Issue.9 , pp. 1819-1829
    • Moffitt, J.H.1    Fielding, B.A.2    Evershed, R.3    Berstan, R.4    Currie, J.M.5    Clark, A.6
  • 96
    • 0028061444 scopus 로고
    • Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region
    • DOI 10.1073/pnas.91.21.9926
    • Moi P, Chan K, Asunis I, Cao A, and Kan YW. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A 91: 9926-9930, 1994. (Pubitemid 24311921)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.21 , pp. 9926-9930
    • Moi, P.1    Chan, K.2    Asunis, I.3    Cao, A.4    Kan, Y.W.5
  • 97
    • 0042812063 scopus 로고    scopus 로고
    • Frame switch splicing and regulated intramembrane proteolysis: Key words to understand the unfolded protein response
    • Mori K. Frame switch splicing and regulated intramembrane proteolysis: key words to understand the unfolded protein response. Traffic 4: 519-528, 2003. (Pubitemid 36896544)
    • (2003) Traffic , vol.4 , Issue.8 , pp. 519-528
    • Mori, K.1
  • 98
    • 33645107263 scopus 로고    scopus 로고
    • Cleavage of the membranebound transcription factor OASIS in response to endoplasmic reticulum stress
    • Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, and Imaizumi K. Cleavage of the membranebound transcription factor OASIS in response to endoplasmic reticulum stress. J Neurochem 96: 1090-1100, 2006.
    • (2006) J Neurochem , vol.96 , pp. 1090-1100
    • Murakami, T.1    Kondo, S.2    Ogata, M.3    Kanemoto, S.4    Saito, A.5    Wanaka, A.6    Imaizumi, K.7
  • 99
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
    • DOI 10.1038/47513
    • Nakagawa T. Caspase-12 mediates endoplasmic-reticulumspecific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103, 2000. (Pubitemid 30038529)
    • (2000) Nature , vol.403 , Issue.6765 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 100
    • 0034698878 scopus 로고    scopus 로고
    • Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis
    • DOI 10.1083/jcb.150.4.887
    • Nakagawa T and Yuan J. Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis. J Cell Biol 150: 887-894, 2000. (Pubitemid 30663424)
    • (2000) Journal of Cell Biology , vol.150 , Issue.4 , pp. 887-894
    • Nakagawa, T.1    Yuan, J.2
  • 101
  • 103
    • 0034755341 scopus 로고    scopus 로고
    • Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
    • DOI 10.1023/A:1012338828418
    • Nehra V, Angulo P, Buchman AL, and Lindor KD. Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 46: 2347-2352, 2001. (Pubitemid 33042332)
    • (2001) Digestive Diseases and Sciences , vol.46 , Issue.11 , pp. 2347-2352
    • Nehra, V.1    Angulo, P.2    Buchman, A.L.3    Lindor, K.D.4
  • 105
    • 63249093704 scopus 로고    scopus 로고
    • Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice
    • Ni HM, Chen X, Shi YH, Liao Y, Beg AA, Fan J, and Yin XM. Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice. J Biol Chem 284: 4373-4382, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 4373-4382
    • Ni, H.M.1    Chen, X.2    Shi, Y.H.3    Liao, Y.4    Beg, A.A.5    Fan, J.6    Yin, X.M.7
  • 106
    • 0030040689 scopus 로고    scopus 로고
    • Regulation of organelle biogenesis
    • DOI 10.1016/S0092-8674(00)81283-0
    • Nunnari J and Walter P. Regulation of organelle biogenesis. Cell 84: 389-394, 1996. (Pubitemid 26058563)
    • (1996) Cell , vol.84 , Issue.3 , pp. 389-394
    • Nunnari, J.1    Walter, P.2
  • 108
    • 23844481790 scopus 로고    scopus 로고
    • Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis
    • DOI 10.1074/jbc.M502685200
    • Obeng EA and Boise LH. Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J Biol Chem 280: 29578-29587, 2005. (Pubitemid 41177033)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.33 , pp. 29578-29587
    • Obeng, E.A.1    Boise, L.H.2
  • 109
    • 0036713724 scopus 로고    scopus 로고
    • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
    • DOI 10.1042/BJ20020391
    • Okada T, Yoshida H, Akazawa R, Negishi M, and Mori K. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366: 585-594, 2002. (Pubitemid 35001703)
    • (2002) Biochemical Journal , vol.366 , Issue.2 , pp. 585-594
    • Okada, T.1    Yoshida, H.2    Akazawa, R.3    Negishi, M.4    Mori, K.5
  • 111
    • 0035873671 scopus 로고    scopus 로고
    • CREB-H: A novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression
    • Omori Y, Imai J-I, Watanabe M, Komatsu T, Suzuki Y, Kataoka K, Watanabe S, Tanigami A, and Sugano S. CREBH: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res 29: 2154-2162, 2001. (Pubitemid 32472086)
    • (2001) Nucleic Acids Research , vol.29 , Issue.10 , pp. 2154-2162
    • Omori, Y.1    Imai, J.-I.2    Watanabe, M.3    Komatsu, T.4    Suzuki, Y.5    Kataoka, K.6    Watanabe, S.7    Tanigami, A.8    Sugano, S.9
  • 113
    • 38149136598 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    • Ota T, Gayet C, and Ginsberg HN. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest 118: 316-322, 2008.
    • (2008) J Clin Invest , vol.118 , pp. 316-322
    • Ota, T.1    Gayet, C.2    Ginsberg, H.N.3
  • 114
    • 44349163999 scopus 로고    scopus 로고
    • Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice
    • DOI 10.1016/j.cmet.2008.04.011, PII S1550413108001435
    • Oyadomari S, Harding H, Zhang Y, Oyadomari M, and Ron D. Dephosphorylation of translation initiation factor 2α enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7: 520-532, 2008. (Pubitemid 351729207)
    • (2008) Cell Metabolism , vol.7 , Issue.6 , pp. 520-532
    • Oyadomari, S.1    Harding, H.P.2    Zhang, Y.3    Oyadomari, M.4    Ron, D.5
  • 116
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • DOI 10.1038/sj.cdd.4401373
    • Oyadomari S and Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389, 2004. (Pubitemid 38489416)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.4 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 118
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • DOI 10.1016/j.molcel.2007.12.023, PII S109727650800066X
    • Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, and Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29: 541-551, 2008. (Pubitemid 351384644)
    • (2008) Molecular Cell , vol.29 , Issue.5 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 119
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • DOI 10.1126/science.1128294
    • Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, and Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313: 1137-1140, 2006. (Pubitemid 44300242)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 120
    • 70349974666 scopus 로고    scopus 로고
    • Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease
    • Pagadala M, Zein CO, and McCullough AJ. Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease. Clin Liver Dis 13: 591-606, 2009.
    • (2009) Clin Liver Dis , vol.13 , pp. 591-606
    • Pagadala, M.1    Zein, C.O.2    McCullough, A.J.3
  • 121
    • 0029001576 scopus 로고
    • A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B
    • Pahl HL and Baeuerle PA. A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J 14: 2580-2588, 1995.
    • (1995) EMBO J , vol.14 , pp. 2580-2588
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 122
    • 34447633011 scopus 로고    scopus 로고
    • Update on non-alcoholic fatty liver disease in children
    • DOI 10.1016/j.clnu.2007.02.002, PII S0261561407000416
    • Papandreou D, Rousso I, and Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clin Nutr 26: 409-415, 2007. (Pubitemid 47091479)
    • (2007) Clinical Nutrition , vol.26 , Issue.4 , pp. 409-415
    • Papandreou, D.1    Rousso, I.2    Mavromichalis, I.3
  • 123
    • 77950523710 scopus 로고    scopus 로고
    • The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
    • Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, and Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med 16: 429-437, 2010.
    • (2010) Nat Med , vol.16 , pp. 429-437
    • Park, S.W.1    Zhou, Y.2    Lee, J.3    Lu, A.4    Sun, C.5    Chung, J.6    Ueki, K.7    Ozcan, U.8
  • 124
    • 77950565682 scopus 로고    scopus 로고
    • Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum
    • Pena F, Jansens A, van Zadelhoff G, and Braakman I. Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum. J Biol Chem 285: 8656-8664, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 8656-8664
    • Pena, F.1    Jansens, A.2    Van Zadelhoff, G.3    Braakman, I.4
  • 125
    • 77950821179 scopus 로고    scopus 로고
    • Linking endoplasmic reticulum stress to cell death in hepatocytes: Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
    • Pfaffenbach KT, Gentile CL, Nivala AM, Wang D, Wei Y, and Pagliassotti MJ. Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab 298: E1026-E1035, 2010.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Pfaffenbach, K.T.1    Gentile, C.L.2    Nivala, A.M.3    Wang, D.4    Wei, Y.5    Pagliassotti, M.J.6
  • 127
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • DOI 10.1053/j.gastro.2007.10.039, PII S0016508507019191
    • Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, and Sanyal AJ. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134: 568-576, 2008. (Pubitemid 351173040)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3    Natarajan, R.4    Maher, J.W.5    Kellum, J.M.6    Sanyal, A.J.7
  • 128
    • 70350365259 scopus 로고    scopus 로고
    • Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling
    • Qiu W, Su Q, Rutledge AC, Zhang J, and Adeli K. Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res 50: 1814-1823, 2009.
    • (2009) J Lipid Res , vol.50 , pp. 1814-1823
    • Qiu, W.1    Su, Q.2    Rutledge, A.C.3    Zhang, J.4    Adeli, K.5
  • 129
    • 0037077295 scopus 로고    scopus 로고
    • A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B
    • DOI 10.1074/jbc.M112448200
    • Rashid KA, Hevi S, Chen Y, Le Caherec F, and Chuck SL. A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B. J Biol Chem 277: 22010-22017, 2002. (Pubitemid 34952355)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.24 , pp. 22010-22017
    • Aftab Rashid, K.1    Hevi, S.2    Chen, Y.3    Caherec, F.L.4    Chuck, S.L.5
  • 130
    • 0038732581 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: From the endoplasmic reticulum to the nucleus
    • Rawson RB. Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus. Essays Biochem 38: 155-168, 2002. (Pubitemid 36589201)
    • (2002) Essays in Biochemistry , vol.38 , pp. 155-168
    • Rawson, R.B.1
  • 132
    • 33751069967 scopus 로고    scopus 로고
    • Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    • DOI 10.1371/journal.pbio.0040374
    • Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Akha AAS, Raden D, and Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol 4: 2024-2041, 2006. (Pubitemid 44760017)
    • (2006) PLoS Biology , vol.4 , Issue.11 , pp. 2024-2041
    • Rutkowski, D.T.1    Arnold, S.M.2    Miller, C.N.3    Wu, J.4    Li, J.5    Gunnison, K.M.6    Mori, K.7    Akha, A.A.S.8    Raden, D.9    Kaufman, R.J.10
  • 133
    • 0347285295 scopus 로고    scopus 로고
    • A trip to the ER: Coping with stress
    • DOI 10.1016/j.tcb.2003.11.001
    • Rutkowski DT and Kaufman RJ. A trip to the ER: coping with stress. Trends Cell Biol 14: 20-28, 2004. (Pubitemid 38076857)
    • (2004) Trends in Cell Biology , vol.14 , Issue.1 , pp. 20-28
    • Rutkowski, D.T.1    Kaufman, R.J.2
  • 136
    • 77349122076 scopus 로고    scopus 로고
    • Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells
    • Sage AT, Walter LA, Shi Y, Khan MI, Kaneto H, Capretta A, and Werstuck GH. Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells. Am J Physiol Endocrinol Metab 298: E499-E511, 2010.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Sage, A.T.1    Walter, L.A.2    Shi, Y.3    Khan, M.I.4    Kaneto, H.5    Capretta, A.6    Werstuck, G.H.7
  • 137
    • 50249187551 scopus 로고    scopus 로고
    • Regulation of ER stress-induced macroautophagy by protein kinase C
    • Sakaki K and Kaufman RJ. Regulation of ER stress-induced macroautophagy by protein kinase C. Autophagy 4: 841-843, 2008.
    • (2008) Autophagy , vol.4 , pp. 841-843
    • Sakaki, K.1    Kaufman, R.J.2
  • 138
    • 70349352744 scopus 로고    scopus 로고
    • Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    • Santos CX, Tanaka LY, Wosniak J, and Laurindo FR. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 11: 2409-2427, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2409-2427
    • Santos, C.X.1    Tanaka, L.Y.2    Wosniak, J.3    Laurindo, F.R.4
  • 139
    • 0038446882 scopus 로고    scopus 로고
    • A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid
    • Santos VN, Lanzoni VP, Szejnfeld J, Shigueoka D, and Parise ER. A randomized double-blind study of the shorttime treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid. Braz J Med Biol Res 36: 723-729, 2003. (Pubitemid 36874723)
    • (2003) Brazilian Journal of Medical and Biological Research , vol.36 , Issue.6 , pp. 723-729
    • Santos, V.N.1    Lanzoni, V.P.2    Szejnfeld, J.3    Shigueoka, D.4    Parise, E.R.5
  • 142
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • DOI 10.1146/annurev.biochem.73.011303.074134
    • Schroder M and Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005. (Pubitemid 40995523)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 145
    • 66049108823 scopus 로고    scopus 로고
    • The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis
    • Sha H, He Y, Chen H, Wang C, Zenno A, Shi H, Yang X, Zhang X, and Qi L. The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab 9: 556-564, 2009.
    • (2009) Cell Metab , vol.9 , pp. 556-564
    • Sha, H.1    He, Y.2    Chen, H.3    Wang, C.4    Zenno, A.5    Shi, H.6    Yang, X.7    Zhang, X.8    Qi, L.9
  • 147
    • 34247568487 scopus 로고    scopus 로고
    • Minimal role for caspase 12 in the unfolded protein response in oligodendrocytes in vivo
    • DOI 10.1111/j.1471-4159.2007.04541.x
    • Sharma R and Gow A. Minimal role for caspase 12 in the unfolded protein response in oligodendrocytes in vivo. J Neurochem 101: 889-897, 2007. (Pubitemid 46683883)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.4 , pp. 889-897
    • Sharma, R.1    Gow, A.2
  • 148
    • 68949196897 scopus 로고    scopus 로고
    • Oxidative folding: Cellular strategies for dealing with the resultant equimolar production of reactive oxygen species
    • Shimizu Y and Hendershot LM. Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Antioxid Redox Signal 9: 2317-2331, 2009.
    • (2009) Antioxid Redox Signal , vol.9 , pp. 2317-2331
    • Shimizu, Y.1    Hendershot, L.M.2
  • 149
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • DOI 10.1053/j.gastro.2007.03.059, PII S0016508507005859
    • Shoelson SE. Obesity, inflammation, and insulin resistance. Gastroenterology 132: 2169-2180, 2007. (Pubitemid 46693756)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 151
    • 55849096988 scopus 로고    scopus 로고
    • Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
    • Song B, Scheuner D, Ron D, Pennathur S, and Kaufman RJ. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118: 3378-3389, 2008.
    • (2008) J Clin Invest , vol.118 , pp. 3378-3389
    • Song, B.1    Scheuner, D.2    Ron, D.3    Pennathur, S.4    Kaufman, R.J.5
  • 152
    • 76349119700 scopus 로고    scopus 로고
    • Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension
    • Sorrentino P, Terracciano L, D'Angelo S, Ferbo U, Bracigliano A, and Vecchione R. Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension. Am J Gastroenterol 105: 336-344, 2010.
    • (2010) Am J Gastroenterol , vol.105 , pp. 336-344
    • Sorrentino, P.1    Terracciano, L.2    D'Angelo, S.3    Ferbo, U.4    Bracigliano, A.5    Vecchione, R.6
  • 153
    • 5444222234 scopus 로고    scopus 로고
    • XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    • DOI 10.1083/jcb.200406136
    • Sriburi R, Jackowski S, Mori K, and Brewer JW. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol 167: 35-41, 2004. (Pubitemid 39363412)
    • (2004) Journal of Cell Biology , vol.167 , Issue.1 , pp. 35-41
    • Sriburi, R.1    Jackowski, S.2    Mori, K.3    Brewer, J.W.4
  • 154
    • 67651171781 scopus 로고    scopus 로고
    • Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance
    • Su Q, Tsai J, Xu E, Qiu W, Bereczki E, Santha M, and Adeli K. Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance. Hepatology 50: 77-84, 2009.
    • (2009) Hepatology , vol.50 , pp. 77-84
    • Su, Q.1    Tsai, J.2    Xu, E.3    Qiu, W.4    Bereczki, E.5    Santha, M.6    Adeli, K.7
  • 156
    • 70349972775 scopus 로고    scopus 로고
    • Apoptosis and cytokines in non-alcoholic steatohepatitis
    • Syn WK, Choi SS, and Diehl AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis 13: 565-580, 2009.
    • (2009) Clin Liver Dis , vol.13 , pp. 565-580
    • Syn, W.K.1    Choi, S.S.2    Diehl, A.M.3
  • 158
    • 2342435179 scopus 로고    scopus 로고
    • Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response
    • DOI 10.1074/jbc.M312144200
    • Tardif K, Mori K, Kaufman RJ, and Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem 279: 17158-17164, 2004. (Pubitemid 38560472)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.17 , pp. 17158-17164
    • Tardif, K.D.1    Mori, K.2    Kaufman, R.J.3    Siddiqui, A.4
  • 159
    • 0036314483 scopus 로고    scopus 로고
    • Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway
    • DOI 10.1128/JVI.76.15.7453-7459.2002
    • Tardif KD, Mori K, and Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol 76: 7453-7459, 2002. (Pubitemid 34760967)
    • (2002) Journal of Virology , vol.76 , Issue.15 , pp. 7453-7459
    • Tardif, K.D.1    Mori, K.2    Siddiqui, A.3
  • 161
    • 70350418594 scopus 로고    scopus 로고
    • Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the golgi complex
    • Testerink N, van der Sanden MH, Houweling M, Helms JB, and Vaandrager AB. Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex. J Lipid Res 50: 2182-2192, 2009.
    • (2009) J Lipid Res , vol.50 , pp. 2182-2192
    • Testerink, N.1    Van Der Sanden, M.H.2    Houweling, M.3    Helms, J.B.4    Vaandrager, A.B.5
  • 163
    • 49449083979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    • Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Konigsrainer A, Maier KP, Bischoff SC, and Bergheim I. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 138: 1452-1455, 2008.
    • (2008) J Nutr , vol.138 , pp. 1452-1455
    • Thuy, S.1    Ladurner, R.2    Volynets, V.3    Wagner, S.4    Strahl, S.5    Konigsrainer, A.6    Maier, K.P.7    Bischoff, S.C.8    Bergheim, I.9
  • 165
    • 3242772953 scopus 로고    scopus 로고
    • Fatty acyl CoA-mediated inhibition of endoplasmic reticulum assembly
    • DOI 10.1016/j.bbamcr.2004.05.002, PII S0167488904001156
    • Turner MD. Fatty acyl CoA-mediated inhibition of endoplasmic reticulum assembly. Biochim Biophys Acta 1693: 1-4, 2004. (Pubitemid 38970130)
    • (2004) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1693 , Issue.1 , pp. 1-4
    • Turner, M.D.1
  • 166
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • DOI 10.1126/science.287.5453.664
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, and Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666, 2000. (Pubitemid 30070916)
    • (2000) Science , vol.287 , Issue.5453 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 170
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • DOI 10.1210/en.2005-0570
    • Wang D, Wei Y, and Pagliassotti MJ. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147: 943-951, 2006. (Pubitemid 43113013)
    • (2006) Endocrinology , vol.147 , Issue.2 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 171
    • 38849146956 scopus 로고    scopus 로고
    • ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones
    • DOI 10.1093/hmg/ddm324
    • Wei H, Kim SJ, Zhang Z, Tsai PC, Wisniewski KE, and Mukherjee AB. ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and nonneurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. Hum Mol Genet 17: 469-477, 2008. (Pubitemid 351201763)
    • (2008) Human Molecular Genetics , vol.17 , Issue.4 , pp. 469-477
    • Wei, H.1    Kim, S.-J.2    Zhang, Z.3    Tsai, P.-C.4    Wisniewski, K.R.5    Mukherjee, A.B.6
  • 172
    • 74049143238 scopus 로고    scopus 로고
    • Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells
    • Wei Y, Wang D, Gentile CL, and Pagliassotti MJ. Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. Mol Cell Biochem 331: 31-40, 2009.
    • (2009) Mol Cell Biochem , vol.331 , pp. 31-40
    • Wei, Y.1    Wang, D.2    Gentile, C.L.3    Pagliassotti, M.J.4
  • 175
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
    • DOI 10.1002/hep.21768
    • Wieckowska A, McCullough AJ, and Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 46: 582-589, 2007. (Pubitemid 47344794)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 176
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • DOI 10.1002/hep.21223
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, and Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44: 27-33, 2006. (Pubitemid 44049136)
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 177
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis
    • DOI 10.1136/gut.48.2.206
    • Wigg AJ, Roberts-Thomson IC, Dymock RB, McCarthy PJ, Grose RH, and Cummins AG. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of nonalcoholic steatohepatitis. Gut 48: 206-211, 2001. (Pubitemid 32141844)
    • (2001) Gut , vol.48 , Issue.2 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3    McCarthy, P.J.4    Grose, R.H.5    Cummins, A.G.6
  • 178
    • 77950537400 scopus 로고    scopus 로고
    • A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
    • Winnay JN, Boucher J, Mori MA, Ueki K, and Kahn CR. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 16: 438-445, 2010.
    • (2010) Nat Med , vol.16 , pp. 438-445
    • Winnay, J.N.1    Boucher, J.2    Mori, M.A.3    Ueki, K.4    Kahn, C.R.5
  • 179
  • 180
    • 73349141743 scopus 로고    scopus 로고
    • Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling
    • Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, and Tabas I. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol 11: 1473-1480, 2009.
    • (2009) Nat Cell Biol , vol.11 , pp. 1473-1480
    • Woo, C.W.1    Cui, D.2    Arellano, J.3    Dorweiler, B.4    Harding, H.5    Fitzgerald, K.A.6    Ron, D.7    Tabas, I.8
  • 182
    • 33645156429 scopus 로고    scopus 로고
    • From acute ER stress to physiological roles of the unfolded protein response
    • Wu J and Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ 13: 374-384, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 374-384
    • Wu, J.1    Kaufman, R.J.2
  • 183
    • 4544253996 scopus 로고    scopus 로고
    • Ultraviolet light activates NFκB through translational inhibition of IκBα synthesis
    • DOI 10.1074/jbc.M405616200
    • Wu S, Tan M, Hu Y, Wang JL, Scheuner D, and Kaufman RJ. Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis. J Biol Chem 279: 34898-34902, 2004. (Pubitemid 39318125)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.33 , pp. 34898-34902
    • Wu, S.1    Tan, M.2    Hu, Y.3    Wang, J.-L.4    Scheuner, D.5    Kaufman, R.J.6
  • 184
    • 26644450729 scopus 로고    scopus 로고
    • Tumor necrosis factor α (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα
    • DOI 10.1074/jbc.M505818200
    • Xue X, Piao JH, Nakajima A, Sakon-Komazawa S, Kojima Y, Mori K, Yagita H, Okumura K, Harding H, and Nakano H. Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem 280: 33917-33925, 2005. (Pubitemid 41443111)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.40 , pp. 33917-33925
    • Xue, X.1    Piao, J.-H.2    Nakajima, A.3    Sakon-Komazawa, S.4    Kojima, Y.5    Mori, K.6    Yagita, H.7    Okumura, K.8    Harding, H.9    Nakano, H.10
  • 185
    • 34548172495 scopus 로고    scopus 로고
    • Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    • DOI 10.1016/j.devcel.2007.07.018, PII S1534580707003000
    • Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A, and Mori K. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell 13: 365-376, 2007. (Pubitemid 47308680)
    • (2007) Developmental Cell , vol.13 , Issue.3 , pp. 365-376
    • Yamamoto, K.1    Sato, T.2    Matsui, T.3    Sato, M.4    Okada, T.5    Yoshida, H.6    Harada, A.7    Mori, K.8
  • 188
    • 64149098793 scopus 로고    scopus 로고
    • Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of bcl-2
    • Yang X and Chan C. Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2. Cell Res 19: 469-486, 2009.
    • (2009) Cell Res , vol.19 , pp. 469-486
    • Yang, X.1    Chan, C.2
  • 189
    • 77449096697 scopus 로고    scopus 로고
    • Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance
    • Ye R, Jung DY, Jun JY, Li J, Luo S, Ko HJ, Kim JK, and Lee AS. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 59: 6-16, 2010.
    • (2010) Diabetes , vol.59 , pp. 6-16
    • Ye, R.1    Jung, D.Y.2    Jun, J.Y.3    Li, J.4    Luo, S.5    Ko, H.J.6    Kim, J.K.7    Lee, A.S.8
  • 192
  • 193
    • 0037470139 scopus 로고    scopus 로고
    • Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B
    • DOI 10.1074/jbc.M207976200
    • Zhang J and Herscovitz H. Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. J Biol Chem 278: 7459-7468, 2003. (Pubitemid 36800752)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.9 , pp. 7459-7468
    • Zhang, J.1    Herscovitz, H.2
  • 194
    • 47949099916 scopus 로고    scopus 로고
    • From endoplasmic reticulum stress to the inflammatory response
    • Zhang K and Kaufman RJ. From endoplasmic reticulum stress to the inflammatory response. Nature 454: 455-462, 2008.
    • (2008) Nature , vol.454 , pp. 455-462
    • Zhang, K.1    Kaufman, R.J.2
  • 195
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • DOI 10.1016/j.cell.2005.11.040, PII S0092867406000043
    • Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, and Kaufman RJ. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124: 587-599, 2006. (Pubitemid 43199443)
    • (2006) Cell , vol.124 , Issue.3 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3    Sakaki, K.4    Saunders, T.5    Rutkowski, D.T.6    Back, S.H.7    Kaufman, R.J.8


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