Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients

Obesity Surgery

Volumn 15, Issue 3, 2005, Pages 310-315

  Ong, Janus P ^a   Elariny, Hazem ^a   Collantes, Rochelle ^a   Younoszai, Abraham ^a   Chandhoke, Vikas ^b   Reines, H David ^a   Goodman, Zachary ^c   Younossi, Zobair M ^a,b  

^a INOVA FAIRFAX HOSPITAL   (United States)

^b GEORGE MASON UNIVERSITY   (United States)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

Bariatric surgery; Cirrhosis; Morbid obesity; NAFLD; Steatohepatitis

Indexed keywords

ASPARTATE AMINOTRANSFERASE;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BARIATRIC SURGERY; DISEASE ASSOCIATION; FEMALE; GENDER; HIP; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; LIVER NECROSIS; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; PREDICTION; PREVALENCE; PRIORITY JOURNAL; UNITED STATES; WAIST CIRCUMFERENCE;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BARIATRICS; BIOPSY; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; FATTY LIVER; FEMALE; FORECASTING; HEPATITIS; HEPATOCYTES; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NECROSIS; OBESITY, MORBID; PROSPECTIVE STUDIES; SEX FACTORS; WAIST-HIP RATIO;

EID: 16244368502     PISSN: 09608923     EISSN: None     Source Type: Journal    
DOI: 10.1381/0960892053576820     Document Type: Article

References (22)

1. Falck-Ytter Y, Younossi ZM, Marchesini G et al. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001; 21: 17-26.
2. Younossi ZM, Diehl AM, Ong JP. Nonalcoholic fatty liver disease: an agenda for clinical research. Hepatology 2002; 35: 746-52.
3. Matteoni CA, Younossi ZM, Gramlich T et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413-9.
4. Younossi ZM, Gramlich T, Liu YC et al. Nonalcoholic fatty liver disease: assessment of variability in pathologic interpretations. Mod Pathol 1998; 11: 560-5.
5. Bugianesi E, Leone N, Vanni E et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134-40.
6. Caldwell SH, Hespenheide EE, Redick JA et al. A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis. Am J Gastroenterology 2001; 96: 519-25.
7. Poonawala A, Nair SP, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 2000; 32: 689-92.
8. Ong J, Younossi ZM, Reddy V et al. Cryptogenic cirrhosis and posttransplantation nonalcoholic fatty liver disease. Liver Transpl 2001; 7: 797-801.
9. Cortez-Pinto H, Camilo ME, Baptista A et al. Non-alcoholic fatty liver: another feature of the metabolic syndrome? Clin Nutr 1999; 18: 353-8.
10. Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001; 21: 27-41.
11. Adler M, Schaffner F. Fatty liver hepatitis and cirrhosis in obese patients. Am J Med 1979; 67: 811-16.
12. Ludwig J, Viggiano TR, McGill DB et al. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 434-8.
13. Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91-100.
14. Abrams GA, Kunde SS, Lazenby AJ et al. Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver disease. Hepatology 2004; 40: 475-83.
15. Shalhub S, Parsee A, Gallagher SF et al. The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients. Obes Surg 2004; 14: 54-9.
16. Moretto M, Kupski C, Mottin CC et al. Hepatic steatosis in patients undergoing bariatric surgery and its relationship to body mass index and co-morbidities. Obes Surg 2003; 13: 622-4.
17. Papadia FS, Marinari GM, Camerini G et al. Liver damage in severely obese patients: a clinical-biochemical-morphologic study on 1,000 liver biopsies. Obes Surg 2004; 14: 952-8.
18. Angulo P, Keach JC, Batts KP et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30: 1356-62.
19. Younossi ZM, Gramlich T, Matteoni CA et al. Nonalcoholic fatty liver disease in patients with type 2 diabetes. Clin Gastroenterol Hepatol 2004; 2: 262-5.
20. Gramlich T, Kleiner DE, McCullough AJ et al. Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. Hum Pathol 2004; 35: 196-9.
21. Ratziu V, Giral P, Charlotte F et al. Liver fibrosis in overweight patients. Gastroenterology 2000; 118: 1117-23.
22. Cortez-Pinto H, Baptista A, Camilo ME et al. Hepatic stellate cell activation occurs in nonalcoholic steatohepatitis. Hepatogastroenterology 2001; 48: 87-90.