Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 6, 1997, Pages 2557-2562

  Yang, Shi Qi ^a   Lin, Hui Zhi ^a   Lane, M Daniel ^a   Clemens, Mark ^a   Diehl, Anna Mae ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cytokines; Kupffer cells; leptin; lipopolysaccharide

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; KUPFFER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RISK FACTOR; SENSITIZATION;

ANIMALS; ESCHERICHIA COLI; FATTY LIVER; FEMALE; HEPATITIS, ANIMAL; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, OBESE; OBESITY; POLYMERASE CHAIN REACTION; RATS; RATS, ZUCKER; SEX CHARACTERISTICS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RODENTIA;

EID: 0001513966     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.6.2557     Document Type: Article

References (52)

1. National Institutes of Health Consensus Development Panel on the Health Implications of Obesity (1985) Ann. Intern. Med. 103, 147-152.
2. Wanless, I. R. & Lentz, J. S. (1990) Hepatology 12, 1106-1110.
3. Leevy, C. M. (1962) Medicine 41, 249-258.
4. Silverman, J. F., O'Brien, K. F., Long, S., Lettett, N., Khazanie, P. G., Pories, W. J., Norris, T. & Caro, J. F. (1990) Am. J. Gastroenterol. 85, 1349-1355.
5. Lee, R. G. (1989) Hum. Pathol. 20, 594-600.
6. Powell, E. E., Cooksley, W. G. E., Hanson, R., Searle, J., Halliday, J. W. & Powell, L. W. (1990) Hepatology 11, 74-80.
7. Bacon, B., Fraavash, M. J., Janney, C. G. & Neuschwander-Tetri, B. A. (1994) Gastroenterology 107, 1103-1109.
8. Haines, N. W., Baker, A. L., Boyer, J. L., Glagov, S., Schneir, H., Jaspan, J. & Ferguson, D. J. (1981) Hepatology 1, 161-165.
9. Vyberg, M., Ravn, V. & Andersen, B. (1987) Liver 7, 271-276.
10. Ludwig, J., Viggiano, T. R., McGill, D. B. & Ott, B. J. (1980) Mayo Clin. Proc. 55, 434-438.
11. Diehl, A. M., Goodman, Z. & Ishak, K. G. (1988) Gastroenterology 95, 1056-1061.
12. Galambos, J. (1972) Gastroenterology 63, 1026-1032.
13. Pares, A., Caballeria, J. & Brugera, M. (1986) J. Hepatol. 2, 33-38.
14. McClain, C. J., Hill, D. B., Schmidt, J. & Diehl, A. M. (1993) Semin. Liver Dis. 13, 170-182.
15. Hoyle, G. W. & Hill, R. L. (1991) J. Biol. Chem. 266, 1850-1857.
16. Chomczynski, P. & Sacchi, N. (1987) Anal. Biochem. 162, 156-161.
17. Yin, M., Yang, S. Q., Lin, H. Z., Lane, M. D., Chatterjee, S. & Diehl, A. M. (1996) J. Biol. Chem. 271, 17974-17978.
18. Rai, R., Yang, S. Q., McClain, C., Karp, C. L., Klein, A. S. & Diehl, A. M. (1996) Am. J. Physiol. 270, G909-G918.
19. Karp, C. L., Wysocka, M., Wahl, L. M., Ahearn, J. M., Cuomo, P. J., Trinchieri, G. & Griffen, D. E. (1996) Science 273, 228-231.
20. Rai, R. M., Zhang, J. X., Clemens, M. G. & Diehl, A. M. (1996) Shock 6, 243-247.
21. Adler, M. & Schaffner, F. (1979) Am. J. Med. 67, 811-817.
22. Torosis, J. D., Barwick, K. W. & Miller, J. D. (1985) Hepatology 9, 237-242.
23. Tracey, K. J. & Cerami, A. (1993) Annu. Rev. Cell Biol. 9, 317-343.
24. Vassalli, P. (1992) Annu. Rev. Immunol. 10, 411-452.
25. Nolan, J. P. (1989) Hepatology 8, 232-236.
26. Pauli, U. (1994) Crit. Rev. Eukaryotic Gene Expression 4, 323-344.
27. Grewe, M., Gaussling, R., Gyuflo, K., Hoffmann, R. & Decker, K. (1994) J. Hepatol. 20, 811-818.
28. Tiegs, G. (1994) J. Hepatol. 21, 890-903.
29. Mohler, K., Sleath, P. & Fitzner, J. (1994) Nature (London) 370, 218-220.
30. Ashkenazi, A., Marsters, A., Capon, D. J., Chamow, S. M., Figari, I. S., Pennica, D., Goeddel, D. V., Palladino, M. A. & Smith, D. H. (1991) Proc. Natl. Acad. Sci. USA 88, 10535-10539.
31. Mizoguchi, Y., Tsutsui, H. & Miyajima, K. (1987) Hepatology 7, 1184-1188.
32. Smith, S., A., C., Bankowski, J., Kenworthy-Bott, L. & Terminelli, C. (1993) J. Leukocyte Biol. 54, 23-29.
33. Honchel, R., Marsano, L., Cohen, D., Shedlofsky, S. & McClain, C. (1991) J. Lab. Clin. Med. 117, 202-208.
34. Clark, G. C., Taylor, M. J., Tritscher, A. M. & Lucier, G. W. (1991) Toxicol. Appl. Pharmacol. 111, 422-431.
35. Colletti, L. M., Remick, D. G., Burtch, G. D., Kunkel, S. L., Strieter, R. M. & Campbell, D. A. J. (1990) J. Clin. Invest. 85, 1936-1943.
36. Hill, D., Shedlofsky, S., McClain, C., Diehl, A. M. & Tsukamoto, H. Cytokines and Liver Disease (Dekker, New York).
37. Leist, M., Gantner, F., Bohlinger, I., Germann, P. G., Tiegs, G. & Wendel, A. (1994) J. Immunol. 153, 1778-1788.
38. Adamson, G. & Billings, R. (1992) Arch. Biochem. Biophys. 294, 223-229.
39. Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G. & Fiers, W. (1993) EMBO. J. 12, 3095-3104.
40. Tiegs, G., Wolter, M. & Wendel, A. (1989) Biochem. Pharmacol. 38, 627-631.
41. Hansen, J., Cherwitz, D. L. & Allen, J. I. (1994) Hepatotogy 20, 461-474.
42. Czaja, M. J., Xu, J. & Alt, E. (1995) Gastroenterology 108, 1849-1854.
43. Blazka, M., Wilmer, J. L., Holladay, S. D., Wilson, R. E. & Luster, M. I. (1995) Toxicol. Appl. Pharmacol. 133, 43-52.
44. Decker, K. (1990) Eur. J. Biochem. 192, 245-261.
45. Fox, E. S., Broitman, S. A. & Thomas, P. (1990) Lab. Invest. 63, 733-736.
46. Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R. & Simsolo, R. B. (1995) J. Clin. Invest. 95, 2111-2119.
47. Yamakawa, T., Tanaka, S.-I., Yamakawa, T., Kiuchi, Y., Isoda, F., Kawamoto, S., Okuda, K. & Sekihara, H. (1995) Immunol. Immunopathol. 75, 51-56.
48. Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F. & Speigelman, B. M. (1996) Science 271, 665-668.
49. Campfield, L. A., Smith, F. J., Buisez, Y., Devos, R. & Burn, P. (1995) Science 269, 546-549.
50. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. & Friedman, J. M. (1995) Science 269, 544-546.
51. Pelleymounter, M. A., Cullen, M. F., Baker, M. B., Hecht, R., Winters, D., Boone, T. & Collins, F. (1995) Science 269, 540-543.
52. Ghilardi, N., Ziegler, S., Wiestner, A., Wiestner, A., Stoffel, R., Heim, M. H. & Skoda, R. C. (1996) Proc. Natl. Acad. Sci. USA 93, 6231-6235.