Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis

Diabetes

Volumn 54, Issue 10, 2005, Pages 2917-2924

  Busch, Anna K ^a   Gurisik, Ebru ^a   Cordery, Damien V ^a   Sudlow, Michelle ^a   Denyer, Gareth S ^b   Ross Laybutt, D ^a   Hughes, William E ^a   Biden, Trevor J ^a,c  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A DESATURASE; CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL ESTER; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; STREPTOZOCIN; TRIACYLGLYCEROL;

APOPTOSIS; ARTICLE; CELL VIABILITY; CHOLESTEROL SYNTHESIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOCYTOSIS; FATTY ACID DESATURATION; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; LIPID COMPOSITION; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CHOLESTEROL ESTERS; DRUG RESISTANCE; FATTY ACID DESATURASES; FATTY ACIDS; ISLETS OF LANGERHANS; LIPIDS; MICE; OXIDATION-REDUCTION; PALMITIC ACID; STEAROYL-COA DESATURASE; TRIGLYCERIDES;

EID: 25844454854     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.10.2917     Document Type: Article

References (37)

1. Porte D, Kahn SE: β-cell dysfunction and failure in type 2 diabetes: potential mechanisms. Diabetes 50:8160-8163, 2001
2. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
3. Donath MY, Halban PA: Decreased β-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47:581-589, 2004
4. Rhodes CJ: Type 2 diabetes-a matter of β-cell life and death? Science 307:380-384, 2005
5. Polonsky KS, Sturis J, Bell GI: Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus: a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med 334:777-783, 1996
6. Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced β cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 95:2498-2502, 1998
7. Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P: Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51:1437-1442, 2002
8. Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY: Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function. Diabetes 52:726-733, 2003
9. Maestre I, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E: Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1. Endocrinology 144:335-345, 2003
10. Piro S, Anello M, Di Pietro C, Lizzio MN, Patane G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F: Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 51:1340-1347, 2002
11. El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M: Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death. Endocrinology 144: 4154-4163, 2003
12. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 100:3077-3082, 2003
13. de Vries JE, Vork MM, Roemen TH, de Jong YF, Cleutjens JP, van der Vusse GJ, van Bilsen M: Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J Lipid Res 38:1384-1394, 1997
14. Hardy S, El-Assaad W, Przybytkowski E, Joly E, Prentki M, Langelier Y: Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells: a role for cardiolipin. J Biol Chem 278:31861-31870, 2003
15. Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY: Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function. Diabetes 50:69-76, 2001
16. Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH: Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci U S A 95:9558-9561, 1998
17. Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unger RH: Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci U S A 96:11513-11518, 1999
18. Listenberger LL, Ory DS, Schaffer JE: Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276:14890-14895, 2001
19. Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J: Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1. Diabetologia 47:249-258, 2004. Epub 2004 Jan 13
20. Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB, Dowhan W: Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J Biol Chem 276:38061-38067, 2001
21. Busch AK, Cordery D, Denyer GS, Biden TJ: Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function. Diabetes 51:977-987, 2002
22. Lepage G, Roy CC: Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 27:114-120, 1986
23. Biden TJ, Robinson D, Cordery D, Hughes WE, Busch AK: Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics. Diabetes 53:8159-8165, 2004
24. Eaton S: Control of mitochondrial beta-oxidation flux. Prog Lipid Res 41:197-239, 2002
25. Buhman KF, Accad M, Farese RV: Mammalian acyl-CoA:cholesterol acyl-transferases. Biochim Biophys Acta 1529:142-154, 2000
26. Chang TY, Chang CC, Cheng D: Acyl-coenzyme A:cholesterol acyltransferase. Annu Rev Biochem 66:613-638, 1997
27. Choi Y, Park Y, Pariza MW, Ntambi JM: Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem Biophys Res Commun 284:689-693, 2001
28. Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG: Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 50:1771-1777, 2001
29. Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH: Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats: role of serine palmitoyltransferase overexpression. J Biol Chem 273:32487-32490, 1998
30. Welters HJ, Smith SA, Tadayyon M, Scarpello JH, Morgan NG: Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 β-cells. J Mol Endocrinol 32:227-235, 2004
31. Man ZW, Zhu M, Noma Y, Toide K, Sato T, Asahi Y, Hiroshima T, Mori S, Kawano K, Mizuno A, Sano T, Shima K: Impaired β-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM. Diabetes 46:1718-1724, 1997
32. Wang H, Maechler P, Antinozzi PA, Herrero L, Hagenfeldt-Johansson KA, Bjorklund A, Wollheim CB: The transcription factor SREBP-1c is instrumental in the development of β-cell dysfunction. J Biol Chem 278:16622-16629, 2003
33. Ramanadham S, Zhang S, Ma Z, Wohltmann M, Bohrer A, Hsu FF, Turk J: Δ6-, stearoyl CoA-, and Δ5-desaturase enzymes are expressed in β-cells and are altered by increases in exogenous PUFA concentrations. Biochim Biophys Acta 1580:40-56, 2002
34. Yu A, McMaster CR, Byers DM, Ridgway ND, Cook HW: Resistance to UV-induced apoptosis in Chinese-hamster ovary cells overexpressing phosphatidylserine synthases. Biochem J 381:609-618, 2004
35. Wright MM, Howe AG, Zaremberg V: Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues. Biochem Cell Biol 82:18-26, 2004
36. Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM: Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing β-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 288:E599-E607, 2005
37. Rahman SM, Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Ntambi JM: Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci U S A 100:11110-11115, 2003