-
1
-
-
0033605371
-
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR
-
Abraham, N. et al. (1999). Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J. Biol. Chem. 274, 5953-5962.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 5953-5962
-
-
Abraham, N.1
-
2
-
-
3242882820
-
PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways
-
Abraham, R. T. (2004). PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst.) 3, 883-887.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 883-887
-
-
Abraham, R.T.1
-
3
-
-
0037064118
-
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR
-
Baltzis, D., Li, S., and Koromilas, A. E. (2002). Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J. Biol. Chem. 277, 38364-38372.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 38364-38372
-
-
Baltzis, D.1
Li, S.2
Koromilas, A.E.3
-
4
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
Beugnet, A., Tee, A. R., Taylor, P. M., and Proud, C. G. (2003). Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem. J. 372, 555-566.
-
(2003)
Biochem. J
, vol.372
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
5
-
-
13644256191
-
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
-
Boyce, M. et al. (2005). A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307, 935-939.
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
-
6
-
-
0036490708
-
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
-
Chan, T. O., Rodeck, U., Chan, A. M., Kimmelman, A. C., Rittenhouse, S. E., Panayotou, G., and Tsichlis, P. N. (2002). Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell 1, 181-191.
-
(2002)
Cancer Cell
, vol.1
, pp. 181-191
-
-
Chan, T.O.1
Rodeck, U.2
Chan, A.M.3
Kimmelman, A.C.4
Rittenhouse, S.E.5
Panayotou, G.6
Tsichlis, P.N.7
-
7
-
-
0001657903
-
Heme-regulated EIF2alpha kinase
-
ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Chen, J. J. (2000). Heme-regulated EIF2alpha kinase. In: Translational Control of Gene Expression., ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 529-546.
-
(2000)
Translational Control of Gene Expression
, pp. 529-546
-
-
Chen, J.J.1
-
8
-
-
0030725442
-
The double-stranded RNA-dependent protein kinase PKR: Structure and function. [Review]
-
Clemens, M. J. and Elia, A. (1997). The double-stranded RNA-dependent protein kinase PKR: structure and function. [Review]. J. Interf. Cytokine Res. 17, 503-524.
-
(1997)
J. Interf. Cytokine Res
, vol.17
, pp. 503-524
-
-
Clemens, M.J.1
Elia, A.2
-
9
-
-
0035920129
-
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
-
Cuevas, B. D., Lu, Y., Mao, M., Zhang, J., LaPushin, R., Siminovitch, K., and Mills, G. B. (2001). Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J. Biol. Chem. 276, 27455-27461.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 27455-27461
-
-
Cuevas, B.D.1
Lu, Y.2
Mao, M.3
Zhang, J.4
LaPushin, R.5
Siminovitch, K.6
Mills, G.B.7
-
10
-
-
0037154965
-
Gene-specific regulation by general translation factors
-
Dever, T. E. (2002). Gene-specific regulation by general translation factors. Cell 108, 545-556.
-
(2002)
Cell
, vol.108
, pp. 545-556
-
-
Dever, T.E.1
-
11
-
-
25144477805
-
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition
-
Dey, M., Cao, C., Dar, A. C., Tamura, T., Ozato, K., Sicheri, F., and Dever, T. E. (2005). Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell 122, 901-913.
-
(2005)
Cell
, vol.122
, pp. 901-913
-
-
Dey, M.1
Cao, C.2
Dar, A.C.3
Tamura, T.4
Ozato, K.5
Sicheri, F.6
Dever, T.E.7
-
12
-
-
1442264796
-
The protein kinase PKR: A molecular clock that sequentially activates survival and death programs
-
Donze, O., Deng, J., Curran, J., Sladek, R., Picard, D., and Sonenberg, N. (2004). The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. EMBO J. 23, 564-571.
-
(2004)
EMBO J
, vol.23
, pp. 564-571
-
-
Donze, O.1
Deng, J.2
Curran, J.3
Sladek, R.4
Picard, D.5
Sonenberg, N.6
-
13
-
-
33750325725
-
S6K1- and beta-TRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
-
Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., and Pagano, M. (2006). S6K1- and beta-TRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314, 467-471.
-
(2006)
Science
, vol.314
, pp. 467-471
-
-
Dorrello, N.V.1
Peschiaroli, A.2
Guardavaccaro, D.3
Colburn, N.H.4
Sherman, N.E.5
Pagano, M.6
-
14
-
-
1342321750
-
PI 3-kinase, Akt and cell survival
-
Downward, J. (2004). PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15, 177-182.
-
(2004)
Semin. Cell Dev. Biol
, vol.15
, pp. 177-182
-
-
Downward, J.1
-
15
-
-
0036209493
-
PKR protection against intranasal vesicular stomatitis virus infection is mouse strain dependent
-
Durbin, R. K., Mertz, S. E., Koromilas, A. E., and Durbin, J. E. (2002). PKR protection against intranasal vesicular stomatitis virus infection is mouse strain dependent. Viral Immunol. 15, 41-51.
-
(2002)
Viral Immunol
, vol.15
, pp. 41-51
-
-
Durbin, R.K.1
Mertz, S.E.2
Koromilas, A.E.3
Durbin, J.E.4
-
16
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman, J. A., Luo, J., and Cantley, L. C. (2006). The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7, 606-619.
-
(2006)
Nat. Rev. Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
17
-
-
1642471831
-
PI3K/Akt and apoptosis: Size matters
-
Franke, T. F., Hornik, C. P., Segev, L., Shostak, G. A., and Sugimoto, C. (2003). PI3K/Akt and apoptosis: size matters. Oncogene 22, 8983-8998.
-
(2003)
Oncogene
, vol.22
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
Shostak, G.A.4
Sugimoto, C.5
-
18
-
-
0033621042
-
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
-
Georgescu, M. M., Kirsch, K. H., Akagi, T., Shishido, T., and Hanafusa, H. (1999). The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc. Natl. Acad. Sci. USA 96, 10182-10187.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 10182-10187
-
-
Georgescu, M.M.1
Kirsch, K.H.2
Akagi, T.3
Shishido, T.4
Hanafusa, H.5
-
19
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
Gingras, A. C., Gygi, S. P., Raught, B., Polakiewicz, R. D., Abraham, R. T., Hoekstra, M. F., Aebersold, R., and Sonenberg, N. (1999a). Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 13, 1422-1437.
-
(1999)
Genes Dev
, vol.13
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
Polakiewicz, R.D.4
Abraham, R.T.5
Hoekstra, M.F.6
Aebersold, R.7
Sonenberg, N.8
-
20
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
Gingras, A. C., Raught, B., Gygi, S. P., Niedzwiecka, A., Miron, M., Burley, S. K., Polakiewicz, R. D., Wyslouch-Cieszynska, A., Aebersold, R., and Sonenberg, N. (2001a). Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15, 2852-2864.
-
(2001)
Genes Dev
, vol.15
, pp. 2852-2864
-
-
Gingras, A.C.1
Raught, B.2
Gygi, S.P.3
Niedzwiecka, A.4
Miron, M.5
Burley, S.K.6
Polakiewicz, R.D.7
Wyslouch-Cieszynska, A.8
Aebersold, R.9
Sonenberg, N.10
-
21
-
-
0032834055
-
eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
Gingras, A. C., Raught, B., and Sonenberg, N. (1999b). eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68, 913-963.
-
(1999)
Annu. Rev. Biochem
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
22
-
-
0035312747
-
Regulation of translation initiation by FRAP/mTOR
-
Gingras, A. C., Raught, B., and Sonenberg, N. (2001b). Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15, 807-826.
-
(2001)
Genes Dev
, vol.15
, pp. 807-826
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
23
-
-
0034254677
-
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein
-
Gout, I., Middleton, G., Adu, J., Ninkina, N. N., Drobot, L. B., Filonenko, V., Matsuka, G., Davies, A. M., Waterheld, M., and Buchman, V. L. (2000). Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. EMBO J. 19, 4015-4025.
-
(2000)
EMBO J
, vol.19
, pp. 4015-4025
-
-
Gout, I.1
Middleton, G.2
Adu, J.3
Ninkina, N.N.4
Drobot, L.B.5
Filonenko, V.6
Matsuka, G.7
Davies, A.M.8
Waterheld, M.9
Buchman, V.L.10
-
24
-
-
0037151120
-
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics
-
Grolleau, A., Bowman, J., Pradet-Balade, B., Puravs, E., Hanash, S., Garcia-Sanz, J. A., and Beretta, L. (2002). Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J. Biol. Chem. 277, 22175-22184.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 22175-22184
-
-
Grolleau, A.1
Bowman, J.2
Pradet-Balade, B.3
Puravs, E.4
Hanash, S.5
Garcia-Sanz, J.A.6
Beretta, L.7
-
25
-
-
0034908630
-
Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells
-
Gupta, S., Stuffrein, S., Plattner, R., Tencati, M., Gray, C., Whang, Y. E., and Stanbridge, E. J. (2001). Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells. Mol. Cell. Biol. 21, 5846-5856.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 5846-5856
-
-
Gupta, S.1
Stuffrein, S.2
Plattner, R.3
Tencati, M.4
Gray, C.5
Whang, Y.E.6
Stanbridge, E.J.7
-
26
-
-
0042355204
-
Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region
-
Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K., and Zhang, J. T. (2003). Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region. Oncogene 22, 5325-5337.
-
(2003)
Oncogene
, vol.22
, pp. 5325-5337
-
-
Han, B.1
Dong, Z.2
Liu, Y.3
Chen, Q.4
Hashimoto, K.5
Zhang, J.T.6
-
27
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., and Ron, D. (2000). Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5, 897-904.
-
(2000)
Mol. Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
28
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N. and Sonenberg, N. (2004). Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
29
-
-
28844434558
-
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko, R. C. and Mueckler, M. (2005). mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280, 40406-40416.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
30
-
-
0001815885
-
Double-stranded RNA-activated protein kinase PKR
-
ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Kaufman, R. J. (2000). Double-stranded RNA-activated protein kinase PKR. In: Translational Control of Gene Expression., ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 503-527.
-
(2000)
Translational Control of Gene Expression
, pp. 503-527
-
-
Kaufman, R.J.1
-
31
-
-
1842505312
-
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: Implications for eIF2 alpha-dependent gene expression and cell death
-
Kazemi, S., Papadopoulou, S., Li, S., Su, Q., Wang, S., Yoshimura, A., Matlashewski, G., Dever, T. E., and Koromilas, A. E. (2004). Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol. Cell. Biol. 24, 3415-3429.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 3415-3429
-
-
Kazemi, S.1
Papadopoulou, S.2
Li, S.3
Su, Q.4
Wang, S.5
Yoshimura, A.6
Matlashewski, G.7
Dever, T.E.8
Koromilas, A.E.9
-
32
-
-
0002664695
-
Regulation of translation initiation in mammalian cells by amino acids
-
ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Kimball, S. R. and Jefferson, L. S. (2000). Regulation of translation initiation in mammalian cells by amino acids. In: Translational Control of Gene Expression., ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 561-579.
-
(2000)
Translational Control of Gene Expression
, pp. 561-579
-
-
Kimball, S.R.1
Jefferson, L.S.2
-
33
-
-
17444449609
-
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: Role of IRF-1 and NF-kappaB
-
Kumar, A., Yang, Y. L., Flati, V., Der, S., Kadereit, S., Deb, A., Haque, J., Reis, L., Weissmann, C., and Williams, B. R. (1997). Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J. 16, 406-416.
-
(1997)
EMBO J
, vol.16
, pp. 406-416
-
-
Kumar, A.1
Yang, Y.L.2
Flati, V.3
Der, S.4
Kadereit, S.5
Deb, A.6
Haque, J.7
Reis, L.8
Weissmann, C.9
Williams, B.R.10
-
34
-
-
1642502331
-
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein
-
Lekmine, F., Sassano, A., Uddin, S., Smith, J., Majchrzak, B., Brachmann, S. M., Hay, N., Fish, E. N., and Platanias, L. C. (2004). Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp. Cell Res. 295, 173-182.
-
(2004)
Exp. Cell Res
, vol.295
, pp. 173-182
-
-
Lekmine, F.1
Sassano, A.2
Uddin, S.3
Smith, J.4
Majchrzak, B.5
Brachmann, S.M.6
Hay, N.7
Fish, E.N.8
Platanias, L.C.9
-
35
-
-
0041344629
-
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons
-
Lekmine, F., Uddin, S., Sassano, A., Parmar, S., Brachmann, S. M., Majchrzak, B., Sonenberg, N., Hay, N., Fish, E. N., and Platanias, L. C. (2003). Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J. Biol. Chem. 278, 27772-27780.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 27772-27780
-
-
Lekmine, F.1
Uddin, S.2
Sassano, A.3
Parmar, S.4
Brachmann, S.M.5
Majchrzak, B.6
Sonenberg, N.7
Hay, N.8
Fish, E.N.9
Platanias, L.C.10
-
36
-
-
0034721874
-
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phosphospecific antibodies
-
Mothe-Satney, I., Brunn, G. J., McMahon, L. P., Capaldo, C. T., Abraham, R. T., and Lawrence, J. C., Jr. (2000). Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phosphospecific antibodies. J. Biol. Chem. 275, 33836-33843.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 33836-33843
-
-
Mothe-Satney, I.1
Brunn, G.J.2
McMahon, L.P.3
Capaldo, C.T.4
Abraham, R.T.5
Lawrence Jr., J.C.6
-
37
-
-
0036327388
-
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex
-
Naga Prasad, S. V., Laporte, S. A., Chamberlain, D., Caron, M. G., Barak, L., and Rockman, H. A. (2002). Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J. Cell Biol. 158, 563-575.
-
(2002)
J. Cell Biol
, vol.158
, pp. 563-575
-
-
Naga Prasad, S.V.1
Laporte, S.A.2
Chamberlain, D.3
Caron, M.G.4
Barak, L.5
Rockman, H.A.6
-
38
-
-
18844457095
-
Mechanisms of type-I- and type-II-interferon- mediated signalling
-
Platanias, L. C. (2005). Mechanisms of type-I- and type-II-interferon- mediated signalling. Nat. Rev. Immunol. 5, 375-386.
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 375-386
-
-
Platanias, L.C.1
-
39
-
-
33750532939
-
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2-GTP·Met-tRNAiMet ternary complex availability
-
Robert, F. et al. (2006). Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2-GTP·Met-tRNAiMet ternary complex availability. Mol. Biol. Cell 17, 4632-4644.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 4632-4644
-
-
Robert, F.1
-
40
-
-
0003113283
-
PERK and translational control by stress in the endoplasmic reticulum
-
ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Ron, D. and Harding, H. P. (2000). PERK and translational control by stress in the endoplasmic reticulum. In: Translational Control of Gene Expression, ed. N. Sonenberg, J.W.B. Hershey, and M. B. Mathews, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 547-560.
-
(2000)
Translational Control of Gene Expression
, pp. 547-560
-
-
Ron, D.1
Harding, H.P.2
-
41
-
-
0004136246
-
-
Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 60-74.
-
(1989)
Molecular Cloning: A Laboratory Manual
, pp. 60-74
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
42
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
43
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
Scheid, M. P. and Woodgett, J. R. (2003). Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 546, 108-112.
-
(2003)
FEBS Lett
, vol.546
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
44
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner, D., Song, B., McEwen, E., Liu, C., Laybutt, R., Gillespie, P., Saunders, T., Bonner-Weir, S., and Kaufman, R. J. (2001). Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7, 1165-1176.
-
(2001)
Mol. Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
Song, B.2
McEwen, E.3
Liu, C.4
Laybutt, R.5
Gillespie, P.6
Saunders, T.7
Bonner-Weir, S.8
Kaufman, R.J.9
-
45
-
-
0041669448
-
SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion
-
Schmidt, M. H., Chen, B., Randazzo, L. M., and Bogler, O. (2003). SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J. Cell Sci. 116, 2845-2855.
-
(2003)
J. Cell Sci
, vol.116
, pp. 2845-2855
-
-
Schmidt, M.H.1
Chen, B.2
Randazzo, L.M.3
Bogler, O.4
-
46
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder, M. and Kaufman, R. J. (2005). The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789.
-
(2005)
Annu. Rev. Biochem
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
47
-
-
14044260466
-
Transcriptional signaling by double-stranded RNA: Role of TLR3
-
Sen, G. C. and Sarkar, S. N. (2005). Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine Growth Factor Rev. 16, 1-14.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 1-14
-
-
Sen, G.C.1
Sarkar, S.N.2
-
48
-
-
33745570504
-
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
-
Shahbazian, D., Roux, P. P., Mieulet, V., Cohen, M. S., Raught, B., Taunton, J., Hershey, J. W., Blenis, J., Pende, M., and Sonenberg, N. (2006). The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25, 2781-2791.
-
(2006)
EMBO J
, vol.25
, pp. 2781-2791
-
-
Shahbazian, D.1
Roux, P.P.2
Mieulet, V.3
Cohen, M.S.4
Raught, B.5
Taunton, J.6
Hershey, J.W.7
Blenis, J.8
Pende, M.9
Sonenberg, N.10
-
49
-
-
30444452652
-
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2{alpha} RNA-dependent protein kinase
-
Su, Q., Wang, S., Baltzis, D., Qu, L. K., Wong, A. H., and Koromilas, A. E. (2006). Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2{alpha} RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 103, 63-68.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 63-68
-
-
Su, Q.1
Wang, S.2
Baltzis, D.3
Qu, L.K.4
Wong, A.H.5
Koromilas, A.E.6
-
50
-
-
0035898611
-
Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR
-
Ung, T. L., Cao, C., Lu, J., Ozato, K., and Dever, T. E. (2001). Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR. EMBO J. 20, 3728-3737.
-
(2001)
EMBO J
, vol.20
, pp. 3728-3737
-
-
Ung, T.L.1
Cao, C.2
Lu, J.3
Ozato, K.4
Dever, T.E.5
-
51
-
-
0036373920
-
Ruk is ubiquitinated but not degraded by the proteasome
-
Verdier, F., Valovka, T., Zhyvoloup, A., Drobot, L. B., Buchman, V., Waterfield, M., and Gout, I. (2002). Ruk is ubiquitinated but not degraded by the proteasome. Eur. J. Biochem. 269, 3402-3408.
-
(2002)
Eur. J. Biochem
, vol.269
, pp. 3402-3408
-
-
Verdier, F.1
Valovka, T.2
Zhyvoloup, A.3
Drobot, L.B.4
Buchman, V.5
Waterfield, M.6
Gout, I.7
-
52
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco, I. and Sawyers, C. L. (2002). The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
53
-
-
33646909758
-
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase
-
Wang, S., Raven, J. F., Baltzis, D., Kazemi, S., Brunet, D. V., Hatzoglou, M., Tremblay, M. L., and Koromilas, A. E. (2006). The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J. Biol. Chem. 281, 9439-9449.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 9439-9449
-
-
Wang, S.1
Raven, J.F.2
Baltzis, D.3
Kazemi, S.4
Brunet, D.V.5
Hatzoglou, M.6
Tremblay, M.L.7
Koromilas, A.E.8
-
54
-
-
15044340650
-
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
-
Wang, X., Beugnet, A., Murakami, M., Yamanaka, S., and Proud, C. G. (2005). Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol. Cell. Biol. 25, 2558-2572.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 2558-2572
-
-
Wang, X.1
Beugnet, A.2
Murakami, M.3
Yamanaka, S.4
Proud, C.G.5
-
55
-
-
0035958080
-
Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR
-
Wong, A. H., Durbin, J. E., Li, S., Dever, T. E., Decker, T., and Koromilas, A. E. (2001). Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR. J. Biol. Chem. 276, 13727-13737.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 13727-13737
-
-
Wong, A.H.1
Durbin, J.E.2
Li, S.3
Dever, T.E.4
Decker, T.5
Koromilas, A.E.6
-
56
-
-
0343852938
-
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
-
Wong, A. H., Tam, N. W., Yang, Y. L., Cuddihy, A. R., Li, S., Kirchhoff, S., Hauser, H., Decker, T., and Koromilas, A. E. (1997). Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. 16, 1291-1304.
-
(1997)
EMBO J
, vol.16
, pp. 1291-1304
-
-
Wong, A.H.1
Tam, N.W.2
Yang, Y.L.3
Cuddihy, A.R.4
Li, S.5
Kirchhoff, S.6
Hauser, H.7
Decker, T.8
Koromilas, A.E.9
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