Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease

Diabetes and Metabolism

Volumn 29, Issue 5, 2003, Pages 478-485

  Diraison, F ^a   Moulin, P H ^b   Beylot, M ^a,c  

^a INSERM   (France)

^b LOUIS PRADEL HOSPITAL   (France)

^c EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Insulin resistance; Liver; Stable isotopes; Steatosis; Triglyceride

Indexed keywords

FATTY ACID DERIVATIVE; PALMITIC ACID; TRIACYLGLYCEROL;

ABSORPTION; ADULT; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; ESTERIFICATION; FEMALE; HUMAN; INSULIN RESISTANCE; LIPOGENESIS; LIVER DISEASE; MALE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0344874201     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(07)70061-7     Document Type: Article

References (44)

1. Mulhall B, Ong J, Younossi Z. Non-alcoholic fatty liver disease: An overview. J Gastroenterol Hepatol, 2002, 17, 1136-43.
2. Day CP, James OFW. Hepatic steatosis: innocent bystander of guilty party? Hepatology, 1998, 27, 1463-6.
3. James O, Day C. Non-alcoholic steatohepatitis: another disease of affluence. Commentary. Lancet, 1999, 353, 1634-47.
4. Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes, 2001, 50, 1844-50.
5. Sanyal A, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic stratohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology, 2001, 120, 1281-5.
6. Dixon JL, Ginsberg HN. Regulation of hepatic secretion of apolipoprotein-B containing lipoproteins: information obtained from cultured liver cells. J Lipid Res, 1993, 34, 167-79.
7. Gibbons GF. Assembly and secretion of hepatic very-low density lipoprotein. Biochem J, 1990, 268, 1-13.
8. Bernard S, Touzet S, Personne I, et al. Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes. Diabetologia, 2000, 43, 995-9.
9. Duerden JM, Gibbons GF. Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes. Biochem J, 1998, 255, 929-35.
10. Francone OL, Griffaton G, Kalopissis A-D. Effect of a high-fat diet on the incorporation of stored triacylglycerol into hepatic VLDL. Am J Physiol. 1992, 263, E615-23.
11. Gibbons GF, Burnham FJ. Effect of nutritional state on the utilization of fatty acids for hepatic triacylglycerol synthesis and secretion as very-low-density lipoprotein. Biochem J, 1991, 275, 87-92.
12. Wiggins D, Gibbons GF. The lipolysis/esterification cycle of hepatic triacylglycerol. Biochem J, 1992, 284, 457-62.
13. Lewis G, Uffelman K, Szeto L, Weller B, Steiner G. Interaction between free fatty acids and insulin in the acute control of VLDL production in humans. J Clin Invest, 1995, 96, 135-40.
14. Diraison F, Beylot M. Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification. Am J Physiol, 1998, 274, E321-7.
15. Diraison F, Dusserre E, Vidal H, Sothier M, Beylot M. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol, 2002, 282, E46-51.
16. Forcheron F, Cachefo A, Thevenon S, Pinteur C, Beylot M. Mechanisms of the triglyceride and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients. Diabetes, 2002, 51, 3486-91.
17. Beylot M, Riou F, Bienvenu F, Mornex R. Increased ketonaemia in hyperthyroidism: evidence for a beta-adrenergic mechanism. Diabetologia, 1980, 19, 505-10.
18. Beylot M, Martin C, Laville M, Riou JP, Cohen R, Mornex R. Lipolytic and ketogenic flux in hyperthyroidism. J Clin Endocrinol Metab, 1991, 73, 42-9.
19. Hales CM, Randle PJ. Immunoassay of insulin with insulin antibody precipitate. Biochem J, 1963, 56, 136-42.
20. Harris V, Faloona G, Unger R. Glucagon. In: Jaffe BM, and H.R. Behrman, ed. Methods of radioimmunoassay. New York: Academic Press, 1979, 643-71.
21. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem, 1957, 226, 497-509.
22. Diraison F, Pachiaudi C, Beylot M. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatography mass spectrometry techniques. J Mass Spectrom, 1997, 32, 81-6.
23. Morrison WR, Smith L. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res, 1964, 5, 600-8.
24. Binnert C, Laville M, Pachiaudi C, Rigalleau V, Beylot M. Use of gas chromatography isotope ratio mass spectrometry to study triglycerides metabolism in humans. Lipids, 1995, 30, 869-73.
25. Yang D, Diraison F, Beylot M, et al. Assay of low deuterium enrichment of water by isotopic exchange with [U-13C] acetone and gas chromatography mass spectrometry. Anal Biochem, 1998, 258,315-21.
26. Guilly RE, Billion-Rey E, Pachiaudi C, et al. On-line purification and carbon 13 isotopic analysis of carbon dioxide in breath: evaluation of on-line gas chromatography isotope ratio mass spectrometry. Anal Chim Acta, 1992, 259, 193-202.
27. Taskinen MR, Beltz WF, Harper I. et al. Effects of non-insulin-dependent diabetes on VLDL triglycerides and apolipoprotein B metabolism Studies before and after sulfonyurea therapy. Diabetes, 1986, 35, 1268-77.
28. Howard B, Reitman J, Vasquez B, Zezch L. Veryl low density lipoprotein triglyceride metabolism in non-insulin-dependent diabetes mellitus. Relationship to plasma insulin and free fatty acids. Diabetes, 1983, 33, 271-6.
29. Sidossis LS, Coggan AR, Gastaldelli A, Wolfe RR. A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am J Physiol, 1995, 269, E649-56.
30. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exhange. J Appl Physio, 1983, 55, 628-34.
31. Patterson B, Mittendorfer B, Ellas N, Satyanarayana R, Klein S. Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Res, 2002, 43, 223-33.
32. Lemieux S, Patterson B, Carpentier A, Lewis G, Steiner G. A stable isotope method using a [2-H5] glycerol bolus to measure very low density lipoprotein triglyceride kinetics in humans. J Lipid Res, 1999, 40, 2111-7.
33. Durrington PN, Newton RS, Weinstein DB, Steinberg D. Effects of insulin and glucose on very low density lipoprotein secretion by cultured rat hepatocytes. J Clin Invest, 1982, 70, 63-73.
34. Lin MCM, Gordon D, Wettereau JR. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res, 1995, 36, 1073-81.
35. Wettereau JR, Aggerbeck LP, Bouma ME, et al. Abscence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science, 1992, 258,999-1001.
36. Faix D, Neese R, Kletke C, et al. Quantification of menstrual and diurnal periodocities in rates of cholesterol and fat synthesis in humans. J Lipid Res, 1993, 34, 2063-75.
37. Girard J, Perdereau P, Foufelle F, Prip-Buus C, Ferre P. Regulation of lipogenic enzyme genes expression by nutrients and hormones. FASEB J, 1994, 8, 36-42.
38. Shimomura I, Bashmakov, Y, Horton J. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem, 1999, 274, 30028-32.
39. Mac Garry JD, Foster D. Regulation of hepatic fatty acids oxidation and ketone body production. Ann Rev Biochem, 1980, 49, 395-411.
40. Havel RJ, Kane JP, Balasse EO, Segel N, Basso LV. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J Clin Invest, 1970, 49, 2017-35.
41. Boberg J, Carlson LA, Freyschuss U. Determination of splanchnic secretion rate of plasma triglyceride and of total and splanchnic turnover of plasma free fatty acid in man. European J Clin Invest, 1972, 2, 123-30.
42. Rasmussen B, Hohnbäck U, Volpi E, Morio-Liondore B, Paddon-Jones D, Wolfe R. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J Clin Invest, 2002, 110, 1687-93.
43. Lehner R, Cui Z, Vance CE. Subcellular localization, developmental expression and characterization of a liver triacylglycerol lipase. Biochem J, 1999, 338, 761-8.
44. Daubioul C, Taper H, De Wispelaere L, Delzenne N. Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese zucker rats. J Nutr. 2000, 130, 1314-9.