BAX and BAK regulation of endoplasmic reticulum Ca2+: A control point for apoptosis

Science

Volumn 300, Issue 5616, 2003, Pages 135-139

  Scorrano, Luca ^a,b   Oakes, Scott A ^a   Opferman, Joseph T ^a   Cheng, Emily H ^a   Sorcinelli, Mia D ^a   Pozzan, Tullio ^b,c   Korsmeyer, Stanley J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; CALCIUM; CELLS;

FIBROBLASTS;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; ARACHIDONIC ACID; CALCIUM ION; CERAMIDE DERIVATIVE; PROTEIN BAK; PROTEIN BAX;

MICROBIOLOGY; PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; ENDOPLASMIC RETICULUM; FIBROBLAST; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CALCIUM SIGNALING; CALCIUM-TRANSPORTING ATPASES; CELL FRACTIONATION; CELL LINE, TRANSFORMED; CELLS, CULTURED; ENDOPLASMIC RETICULUM; HISTAMINE; HYDROGEN PEROXIDE; IONOMYCIN; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, IMMUNOELECTRON; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SPHINGOSINE;

ANIMALIA;

EID: 0037418843     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1081208     Document Type: Article

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32. We thank A. Vukovic and C. Ong for technical assistance, and E. Smith for editorial assistance. L.S. is a Human Frontier Science Program fellow and a Dulbecco-Telethon Institute Assistant Scientist. Supported by NIH training grant T32HL07627 (S.A.O.), a postdoctoral fellowship (DRG 1664) from the Damon Runyon Cancer Research Foundation (J.T.O.), and NIH grant R37CA50239.