Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

Diabetologia

Volumn 48, Issue 9, 2005, Pages 1819-1829

  Moffitt, J H ^a   Fielding, B A ^a   Evershed, R ^b   Berstan, R ^b   Currie, J M ^a   Clark, A ^a  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Beta cell; ER stress; INS1; Insulin; Lipotoxicity; Oleate; Palmitate; Phospholipid; Triglyceride; Tripalmitin

Indexed keywords

ALBUMIN; FATTY ACID; GLUCOSE; HEAT SHOCK PROTEIN; INSULIN; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHOLIPID; SATURATED FATTY ACID; TRIACYLGLYCEROL; TRIPALMITIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS CHROMATOGRAPHY; INCUBATION TIME; INSULIN RELEASE; MELTING POINT; MICROSCOPY; MORPHOLOGY; NONHUMAN; PANCREAS ISLET BETA CELL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; INSULIN; INSULINOMA; LINOLEIC ACID; MICE; OLEIC ACID; PALMITIC ACID; PANCREATIC NEOPLASMS; PHOSPHOLIPIDS; TRIGLYCERIDES;

EID: 24944526652     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1861-9     Document Type: Article

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