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Volumn 5, Issue 1, 2004, Pages 27-42

Hepatic steatosis in obese patients: Clinical aspects and prognostic significance

Author keywords

Insulin resistance; Metabolic syndrome; Non alcoholic steatohepatitis; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CYTOKINE; INSULIN SENSITIZING AGENT; TRIACYLGLYCEROL;

EID: 0842269198     PISSN: 14677881     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1467-789X.2004.00126.x     Document Type: Review
Times cited : (263)

References (155)
  • 4
    • 0037010474 scopus 로고    scopus 로고
    • Selected major risk factors and global and regional burden of disease
    • Ezzati M, Lopez AD, Rodgers A, Van der Hoorn S, Murray CJL and the Comparative Risk Assessment Collaborating Group. Selected major risk factors and global and regional burden of disease. Lancet 2002; 360: 1347-1360.
    • (2002) Lancet , vol.360 , pp. 1347-1360
    • Ezzati, M.1    Lopez, A.D.2    Rodgers, A.3    Van Der Hoorn, S.4    Murray, C.J.L.5
  • 5
    • 0038707252 scopus 로고    scopus 로고
    • Review article: Non-alcoholic fatty liver disease
    • Alba LM, Lindor K. Review article: non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2003; 17: 977-986.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 977-986
    • Alba, L.M.1    Lindor, K.2
  • 6
    • 0037129380 scopus 로고    scopus 로고
    • Non alcoholic fatty liver disease
    • Angulo P. Non alcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 7
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis
    • Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001; 21: 27-41.
    • (2001) Semin Liver Dis , vol.21 , pp. 27-41
    • Chitturi, S.1    Farrell, G.C.2
  • 8
    • 0033562693 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis. Another disease of affluence
    • James O, Day C. Non-alcoholic steatohepatitis. another disease of affluence. Lancet 1999; 353: 1634-1636.
    • (1999) Lancet , vol.353 , pp. 1634-1636
    • James, O.1    Day, C.2
  • 10
    • 0034748682 scopus 로고    scopus 로고
    • Correlation of abdominal fat accumulation and liver steatosis: Importance of ultrasonographic and anthropometric measurements
    • Sabir N, Sermez Y, Kazil S, Zencir M. Correlation of abdominal fat accumulation and liver steatosis: importance of ultrasonographic and anthropometric measurements. Eur J Ultrasound 2001; 14: 121-128.
    • (2001) Eur J Ultrasound , vol.14 , pp. 121-128
    • Sabir, N.1    Sermez, Y.2    Kazil, S.3    Zencir, M.4
  • 14
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD single topic conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 2003; 37: 1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 15
    • 0022356384 scopus 로고
    • Characteristic sonographic signs of hepatic fatty infiltration
    • Quinn SF, Gosink BB. Characteristic sonographic signs of hepatic fatty infiltration. Am J Roentgenol 1985; 145: 753-755.
    • (1985) Am J Roentgenol , vol.145 , pp. 753-755
    • Quinn, S.F.1    Gosink, B.B.2
  • 16
    • 0037223610 scopus 로고    scopus 로고
    • Defining nonalcoholic fatty liver disease: Implications for epidemiological studies
    • Clark JM, Diehl AM. Defining nonalcoholic fatty liver disease: implications for epidemiological studies. Gastroenterology 2003; 124: 248-250.
    • (2003) Gastroenterology , vol.124 , pp. 248-250
    • Clark, J.M.1    Diehl, A.M.2
  • 17
    • 0033797838 scopus 로고    scopus 로고
    • Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: A case-control study
    • Poonawala A, Nair S, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 2000; 32: 689-692.
    • (2000) Hepatology , vol.32 , pp. 689-692
    • Poonawala, A.1    Nair, S.2    Thuluvath, P.J.3
  • 19
    • 0036724436 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: A common cause of progressive chronic liver injury?
    • Evans CD, Oien KA, MacSween RNM, Mills PR. Non-alcoholic steatohepatitis: a common cause of progressive chronic liver injury? J Clin Pathol 2002; 55: 689-692.
    • (2002) J Clin Pathol , vol.55 , pp. 689-692
    • Evans, C.D.1    Oien, K.A.2    MacSween, R.N.M.3    Mills, P.R.4
  • 20
    • 0037221394 scopus 로고    scopus 로고
    • Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States
    • Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003; 124: 71-79.
    • (2003) Gastroenterology , vol.124 , pp. 71-79
    • Ruhl, C.E.1    Everhart, J.E.2
  • 22
    • 0037299949 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: What is it, and why is it important in the Asia-Pacific region?
    • Farrell GC. Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region? J Gastroenterol Hepatol 2003; 18: 124-138.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 124-138
    • Farrell, G.C.1
  • 23
    • 0242475802 scopus 로고    scopus 로고
    • Prevalence and risk factors for nonalcoholic fatty liver in Indonesia
    • Hasan I, Gani RA, Machmud R. Prevalence and risk factors for nonalcoholic fatty liver in Indonesia. J Gastroenterol Hepatol 2002; 17: A30.
    • (2002) J Gastroenterol Hepatol , vol.17
    • Hasan, I.1    Gani, R.A.2    Machmud, R.3
  • 24
    • 0038544021 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver among administrative officiers in Shangai: An epidemiological survey
    • Shen L, Fan JG, Shao Y, Zeng MD, Wang JR, Luo GH, Li JQ, Chen SY. Prevalence of nonalcoholic fatty liver among administrative officiers in Shangai: an epidemiological survey. World J Gastroenterol 2003; 9: 1106-1110.
    • (2003) World J Gastroenterol , vol.9 , pp. 1106-1110
    • Shen, L.1    Fan, J.G.2    Shao, Y.3    Zeng, M.D.4    Wang, J.R.5    Luo, G.H.6    Li, J.Q.7    Chen, S.Y.8
  • 26
    • 0028810805 scopus 로고
    • Prevalence of fatty liver in Japanese children and relationship to obesity: An epidemiological ultrasonographic survey
    • Tominaga K, Kurata JH, Chen YK, Fujimoto E, Miyagawa S, Abe I, Kusano Y. Prevalence of fatty liver in Japanese children and relationship to obesity: an epidemiological ultrasonographic survey. Dig Dis Sci 1995; 40: 2002-2009.
    • (1995) Dig Dis Sci , vol.40 , pp. 2002-2009
    • Tominaga, K.1    Kurata, J.H.2    Chen, Y.K.3    Fujimoto, E.4    Miyagawa, S.5    Abe, I.6    Kusano, Y.7
  • 27
    • 0030872385 scopus 로고    scopus 로고
    • Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosing and during follow-up in an Italian population
    • Franzese A, Vajro P, Argenziano A, Puzziello A, Iannucci MP, Saviano MC, Brunetti M, Rubino A. Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosing and during follow-up in an Italian population. Dig Dis Sci 1997; 42: 1438-1442.
    • (1997) Dig Dis Sci , vol.42 , pp. 1438-1442
    • Franzese, A.1    Vajro, P.2    Argenziano, A.3    Puzziello, A.4    Iannucci, M.P.5    Saviano, M.C.6    Brunetti, M.7    Rubino, A.8
  • 29
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang SO, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acd Sci USA 1997; 94: 2557-2562.
    • (1997) Proc Natl Acd Sci USA , vol.94 , pp. 2557-2562
    • Yang, S.O.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 30
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-1364.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 36
    • 0034631865 scopus 로고    scopus 로고
    • Screening for alcohol problems in primary care. A systematic review
    • Fiellin DA, Reid MC, O'Connor PG. Screening for alcohol problems in primary care. A systematic review. Arch Intern Med 2000; 160: 1977-1989.
    • (2000) Arch Intern Med , vol.160 , pp. 1977-1989
    • Fiellin, D.A.1    Reid, M.C.2    O'Connor, P.G.3
  • 39
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30: 1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 45
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. JAMA 2001; 285: 2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 47
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two 'hits'?
    • Day C, James O. Steatohepatitis: a tale of two 'hits'? Gastroenterology 1998; 114: 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.1    James, O.2
  • 49
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocrine Rev 2002; 23: 201-229.
    • (2002) Endocrine Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 50
    • 0029938022 scopus 로고    scopus 로고
    • Glucose transporters in the regulation of intestinal, renal and liver glucose fluxes
    • Thorens B. Glucose transporters in the regulation of intestinal, renal and liver glucose fluxes. Am J Physiol 1996; 270: G451-G453.
    • (1996) Am J Physiol , vol.270
    • Thorens, B.1
  • 51
    • 0032533162 scopus 로고    scopus 로고
    • Specific features of glycogen metabolism in the liver
    • Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 1998; 336: 19-31.
    • (1998) Biochem J , vol.336 , pp. 19-31
    • Bollen, M.1    Keppens, S.2    Stalmans, W.3
  • 52
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glicolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c
    • Foufelle F, Ferrè P. New perspectives in the regulation of hepatic glicolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002; 366: 377-391.
    • (2002) Biochem J , vol.366 , pp. 377-391
    • Foufelle, F.1    Ferrè, P.2
  • 54
    • 0342314436 scopus 로고    scopus 로고
    • Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
    • Ryysy L, Häkkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, Yki-Jarvinen H. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 2000; 49: 749-758.
    • (2000) Diabetes , vol.49 , pp. 749-758
    • Ryysy, L.1    Häkkinen, A.M.2    Goto, T.3    Vehkavaara, S.4    Westerbacka, J.5    Halavaara, J.6    Yki-Jarvinen, H.7
  • 55
    • 50549202600 scopus 로고
    • The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; i: 785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 58
    • 0036841764 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: What we know in the new millennium
    • Harrison SA, Kadakia S, Lang KA, Schenker S. Nonalcoholic steatohepatitis: what we know in the new millennium. Am J Gastroenterol 2002; 97: 2714-2724.
    • (2002) Am J Gastroenterol , vol.97 , pp. 2714-2724
    • Harrison, S.A.1    Kadakia, S.2    Lang, K.A.3    Schenker, S.4
  • 59
    • 0037085471 scopus 로고    scopus 로고
    • Blocking the secretion of hepatic very low density lipoprotein renders the liver more susceptible to fixed drug injury
    • Bjorkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG. Blocking the secretion of hepatic very low density lipoprotein renders the liver more susceptible to fixed drug injury. J Biol Chem 2002; 277: 5476-5483.
    • (2002) J Biol Chem , vol.277 , pp. 5476-5483
    • Bjorkegren, J.1    Beigneux, A.2    Bergo, M.O.3    Maher, J.J.4    Young, S.G.5
  • 60
    • 0030467446 scopus 로고    scopus 로고
    • The OB protein (leptin) pathway: A link between adipose tissue mass and central neural networks
    • Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway: a link between adipose tissue mass and central neural networks. Horm Metab Res 1996; 28: 619-632.
    • (1996) Horm Metab Res , vol.28 , pp. 619-632
    • Campfield, L.A.1    Smith, F.J.2    Burn, P.3
  • 63
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • Saxena NK, Ikeda K, Rockey DC, Friedman SI, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 2002; 35: 762-771.
    • (2002) Hepatology , vol.35 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.I.4    Anania, F.A.5
  • 64
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodelling of extracellular matrix in the rat
    • Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, Zhang YJ, Lang T. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodelling of extracellular matrix in the rat. Gastroenterology 2002; 122: 1399-1410.
    • (2002) Gastroenterology , vol.122 , pp. 1399-1410
    • Ikejima, K.1    Takei, Y.2    Honda, H.3    Hirose, M.4    Yoshikawa, M.5    Zhang, Y.J.6    Lang, T.7
  • 65
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger RH. Lipotoxic diseases. Ann Rev Med 2002; 53: 319-336.
    • (2002) Ann Rev Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 66
    • 0011120363 scopus 로고    scopus 로고
    • A genetic mutation in the proliferators activated receptor alpha (PPAR-A) gene in patients with non-alcoholic steatohepatitis
    • Molley MJ, Kane JP, Bacon B. A genetic mutation in the proliferators activated receptor alpha (PPAR-A) gene in patients with non-alcoholic steatohepatitis. Hepatology 2001; 34: 441.
    • (2001) Hepatology , vol.34 , pp. 441
    • Molley, M.J.1    Kane, J.P.2    Bacon, B.3
  • 67
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis
    • Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis. J Clin Invest 2000; 105: 1067-1075.
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 73
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver disease in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KSL, Cooper GJS. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver disease in mice. J Clin Invest 2003; 112: 91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 75
    • 0016264245 scopus 로고
    • Injury produced by free fatty acids to lysosomes amd mitochondria in cultures of heart muscle and endothelial cells
    • Acosta D, Wenzel DG. Injury produced by free fatty acids to lysosomes amd mitochondria in cultures of heart muscle and endothelial cells. Atherosclerosis 1974; 20: 417-426.
    • (1974) Atherosclerosis , vol.20 , pp. 417-426
    • Acosta, D.1    Wenzel, D.G.2
  • 76
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
    • Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 1996; 111: 1645-1653.
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrell, G.C.2    Liddle, C.3
  • 77
    • 0035082455 scopus 로고    scopus 로고
    • Paroxysmal-oxidation and steatohepatitis
    • Rao MS, Reddy JK. Paroxysmal-oxidation and steatohepatitis. Semin Liver Dis 2001; 21: 43-55.
    • (2001) Semin Liver Dis , vol.21 , pp. 43-55
    • Rao, M.S.1    Reddy, J.K.2
  • 78
    • 0038621885 scopus 로고    scopus 로고
    • Interaction of iron, insulin resistance, and nonalcoholic steatohepatitis
    • Chitturi S, George J. Interaction of iron, insulin resistance, and nonalcoholic steatohepatitis. Curr Gastroenterol Rep 2003; 5: 18-25.
    • (2003) Curr Gastroenterol Rep , vol.5 , pp. 18-25
    • Chitturi, S.1    George, J.2
  • 79
    • 0036718446 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis and the role of antioxidants
    • Metha K, Van Thiel DH, Shah N, Mobarhan S. Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. Nutrition Rev 2002; 60: 289-293.
    • (2002) Nutrition Rev , vol.60 , pp. 289-293
    • Metha, K.1    Van Thiel, D.H.2    Shah, N.3    Mobarhan, S.4
  • 80
    • 0029142555 scopus 로고
    • Nuclear migration of NF-KB correlates with TNF-mRNA accumulation
    • Albrecht H, Schook LB, Jongeneel CV. Nuclear migration of NF-KB correlates with TNF-mRNA accumulation. J Inflamm 1995; 45: 64-71.
    • (1995) J Inflamm , vol.45 , pp. 64-71
    • Albrecht, H.1    Schook, L.B.2    Jongeneel, C.V.3
  • 81
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity and diet induced insulin resistance with salicylates or targeted disruption of IKK-beta
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity and diet induced insulin resistance with salicylates or targeted disruption of IKK-beta. Science 2001; 293: 1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 85
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and non alcoholic steatohepatitis
    • Tilg H, Diehl AM. Cytokines in alcoholic and non alcoholic steatohepatitis. N Engl J Med 2000; 343: 1467-1476.
    • (2000) N Engl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 87
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995; 22: 1714-1719.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 88
    • 0015166045 scopus 로고
    • Natural history of alcoholic hepatitis. II: The long-term prognosis
    • Alexander JF, Lischner MW, Galambos JT. Natural history of alcoholic hepatitis. II: the long-term prognosis. Am J Gastroenterol 1971; 56: 515-525.
    • (1971) Am J Gastroenterol , vol.56 , pp. 515-525
    • Alexander, J.F.1    Lischner, M.W.2    Galambos, J.T.3
  • 89
    • 0038142845 scopus 로고    scopus 로고
    • Non alcoholic fatty liver disease. An underrecognized cause of cryptogenic cirrhosis
    • Clark JM, Diehl AM. Non alcoholic fatty liver disease. An underrecognized cause of cryptogenic cirrhosis. JAMA 2003; 289: 3000-3004.
    • (2003) JAMA , vol.289 , pp. 3000-3004
    • Clark, J.M.1    Diehl, A.M.2
  • 90
    • 0036288123 scopus 로고    scopus 로고
    • Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis?
    • Nair S, Mason A, Eason J, Loss G, Perrillo RP. Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis? Hepatology 2002; 36: 150-155.
    • (2002) Hepatology , vol.36 , pp. 150-155
    • Nair, S.1    Mason, A.2    Eason, J.3    Loss, G.4    Perrillo, R.P.5
  • 96
    • 0034831067 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • Reid AE. Nonalcoholic steatohepatitis. Gastroenterology 2001; 121: 710-723.
    • (2001) Gastroenterology , vol.121 , pp. 710-723
    • Reid, A.E.1
  • 97
    • 0037464510 scopus 로고    scopus 로고
    • Over-weight, obesity, and mortality from cancer in a prospectively studied cohort of US adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Over-weight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med 2003; 348: 1625-1638.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 99
    • 0036894480 scopus 로고    scopus 로고
    • NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
    • Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 2002, 36, 1349-1354.
    • (2002) Hepatology , vol.36 , pp. 1349-1354
    • Marrero, J.A.1    Fontana, R.J.2    Su, G.L.3    Conjeevaram, H.S.4    Emick, D.M.5    Lok, A.S.6
  • 102
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • Palmer M, Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 1990; 99: 1408-1413.
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 103
    • 0036829752 scopus 로고    scopus 로고
    • American Gastroenterological Association Medical Position Statement: Nonalcoholic fatty liver disease
    • Sanyal AJ. American Gastroenterological Association Medical Position Statement: nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 1702-1725.
    • (2002) Gastroenterology , vol.123 , pp. 1702-1725
    • Sanyal, A.J.1
  • 105
    • 0033862760 scopus 로고    scopus 로고
    • Diabetes guidelines: A summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical Endocrinologists
    • Clark MJ, Sterrett JJ, Carson DS. Diabetes guidelines: a summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical Endocrinologists. Clin Ther 2000; 22: 899-910.
    • (2000) Clin Ther , vol.22 , pp. 899-910
    • Clark, M.J.1    Sterrett, J.J.2    Carson, D.S.3
  • 107
    • 0000906311 scopus 로고    scopus 로고
    • Metformin treatment in patients with nonalcoholic steatohepatitis normalizes LFTs and improves histology
    • Coyle WJ, Delaney N, Yoshihashi A, Lawson P. Metformin treatment in patients with nonalcoholic steatohepatitis normalizes LFTs and improves histology. Gastroenterology 1999; 116: A1198.
    • (1999) Gastroenterology , vol.116
    • Coyle, W.J.1    Delaney, N.2    Yoshihashi, A.3    Lawson, P.4
  • 113
    • 0141532275 scopus 로고    scopus 로고
    • Improved non-alcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oivier D, Bacon BR. Improved non-alcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone. Hepatology 2003; 38: 1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oivier, D.4    Bacon, B.R.5
  • 115
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol 1999; 31: 384.
    • (1999) J Hepatol , vol.31 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 116
    • 0033594768 scopus 로고    scopus 로고
    • Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis
    • Saibara T, Onishi S, Ogawa Y, Yoshida S, Enzan H. Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis. Lancet 1999; 353: 1802.
    • (1999) Lancet , vol.353 , pp. 1802
    • Saibara, T.1    Onishi, S.2    Ogawa, Y.3    Yoshida, S.4    Enzan, H.5
  • 118
    • 0038471742 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors in no alcoholic fatty liver disease. Is their potential hepatotoxicity an issue in these patients? A case control study based on histology
    • Nair S, Wiseman M. HMG-CoA reductase inhibitors in no alcoholic fatty liver disease. is their potential hepatotoxicity an issue in these patients? A case control study based on histology. Hepatology 2002; 36: 409A.
    • (2002) Hepatology , vol.36
    • Nair, S.1    Wiseman, M.2
  • 120
    • 0035085858 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver: Present and emerging therapies
    • Angulo P, Lindor K. Treatment of nonalcoholic fatty liver: present and emerging therapies. Semin Liver Dis 2001; 21: 81-88.
    • (2001) Semin Liver Dis , vol.21 , pp. 81-88
    • Angulo, P.1    Lindor, K.2
  • 121
    • 0036211568 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An agenda for clinical research
    • Younossi ZM, Diehl AM, Ong JP. Nonalcoholic fatty liver disease: an agenda for clinical research. Hepatology 2002; 35: 746-752.
    • (2002) Hepatology , vol.35 , pp. 746-752
    • Younossi, Z.M.1    Diehl, A.M.2    Ong, J.P.3
  • 122
    • 0031950282 scopus 로고    scopus 로고
    • Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis modulating mitochondrial transmembrane potential and reactive oxygen species production
    • Rodriguez CMP, Fan GS, Wong PY, Kren BT, Steer CJ. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med 1998; 4: 165-178.
    • (1998) Mol Med , vol.4 , pp. 165-178
    • Rodriguez, C.M.P.1    Fan, G.S.2    Wong, P.Y.3    Kren, B.T.4    Steer, C.J.5
  • 125
    • 0001083778 scopus 로고    scopus 로고
    • Ursodeoxycholic acid in the treatment of nonalcoholic steatohepatitis: Results of a prospective clinical controlled trial
    • Guma G, Viola L, Thomé M, Galdame O, Alverez E. Ursodeoxycholic acid in the treatment of nonalcoholic steatohepatitis: results of a prospective clinical controlled trial. Hepatology 1997; 26: 387A.
    • (1997) Hepatology , vol.26
    • Guma, G.1    Viola, L.2    Thomé, M.3    Galdame, O.4    Alverez, E.5
  • 126
    • 0000685882 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid plus diet in patients with nonalcoholic steatohepatitis
    • Ceriani R, Bunati S, Morini L, Sacchi E, Colombo G. Effect of ursodeoxycholic acid plus diet in patients with nonalcoholic steatohepatitis. Hepatology 1998; 28: 386A.
    • (1998) Hepatology , vol.28
    • Ceriani, R.1    Bunati, S.2    Morini, L.3    Sacchi, E.4    Colombo, G.5
  • 127
    • 0038132646 scopus 로고    scopus 로고
    • Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease: A randomized double-blind, placebo controlled trial
    • Mendez-Sanchez N, Gonzalez V, Pichardo-Bahena R, Uribe M. Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease: a randomized double-blind, placebo controlled trial. Hepatology 2002; 36: 412A.
    • (2002) Hepatology , vol.36
    • Mendez-Sanchez, N.1    Gonzalez, V.2    Pichardo-Bahena, R.3    Uribe, M.4
  • 128
    • 0034834208 scopus 로고    scopus 로고
    • Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: Results of a pilot study
    • Abdelmalek MF, Angulo P, Jorgensen RA, Sylvestre PB, Lindor KD. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001; 96: 2711-2717.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2711-2717
    • Abdelmalek, M.F.1    Angulo, P.2    Jorgensen, R.A.3    Sylvestre, P.B.4    Lindor, K.D.5
  • 129
    • 0033884107 scopus 로고    scopus 로고
    • Efficacy and safety of oral beatine glucuronate in non-alcohol steatohepatitis. A double-blind, randomized parallel group, placebo-controlled prospective clinical study
    • Miglio F, Rovati LC, Santoro A, Semikar I. Efficacy and safety of oral beatine glucuronate in non-alcohol steatohepatitis. A double-blind, randomized parallel group, placebo-controlled prospective clinical study. Arzneimittelforschung 2000; 50: 722-727.
    • (2000) Arzneimittelforschung , vol.50 , pp. 722-727
    • Miglio, F.1    Rovati, L.C.2    Santoro, A.3    Semikar, I.4
  • 130
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
    • Levine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr 2000; 136: 734-738.
    • (2000) J Pediatr , vol.136 , pp. 734-738
    • Levine, J.E.1
  • 131
    • 0033979964 scopus 로고    scopus 로고
    • A-Tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals
    • van Tits LJ, Demaker PN, de Graaf J, Hak-Lemmers HL, Stalenhoef AF. A-Tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am J Clin Nutr 2000; 71: 458-464.
    • (2000) Am J Clin Nutr , vol.71 , pp. 458-464
    • Van Tits, L.J.1    Demaker, P.N.2    De Graaf, J.3    Hak-Lemmers, H.L.4    Stalenhoef, A.F.5
  • 132
    • 0030854425 scopus 로고    scopus 로고
    • A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C
    • Houglum K, Venkataramuni A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 1997; 113: 1069-1073.
    • (1997) Gastroenterology , vol.113 , pp. 1069-1073
    • Houglum, K.1    Venkataramuni, A.2    Lyche, K.3    Chojkier, M.4
  • 133
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-β level and efficacy of α-tocopherol in patients with non-alcoholic hepatitis: A pilot study
    • Hasewaga T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-β level and efficacy of α-tocopherol in patients with non-alcoholic hepatitis: a pilot study. Aliment Pharmacol Ther 2001; 15: 1667-1672.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasewaga, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 134
    • 0008731894 scopus 로고    scopus 로고
    • Effect of phlebotomy on serum ALT levels in patients with non-alcoholic steatohepatitis and stainable hepatic iron
    • Macdonald GA, Dixon J, Powell LW. Effect of phlebotomy on serum ALT levels in patients with non-alcoholic steatohepatitis and stainable hepatic iron. Hepatology 2001; 34: 457A.
    • (2001) Hepatology , vol.34
    • Macdonald, G.A.1    Dixon, J.2    Powell, L.W.3
  • 135
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of non-alcoholic fatty liver disease
    • Facchini FS, Hua NW, Stoohs RA. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of non-alcoholic fatty liver disease. Gastroenterology 2002; 122: 931-939.
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 136
    • 0141594639 scopus 로고    scopus 로고
    • Is obesity a risk factor for cirrhosis-related death or hospitalization? A population-based cohort study
    • Ioannou GN, Weiss NS, Kowdley KV, Dominitz JA. Is obesity a risk factor for cirrhosis-related death or hospitalization? A population-based cohort study. Gastroenterology 2003; 125: 1053-1059.
    • (2003) Gastroenterology , vol.125 , pp. 1053-1059
    • Ioannou, G.N.1    Weiss, N.S.2    Kowdley, K.V.3    Dominitz, J.A.4
  • 139
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990; 12: 1106-1110.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 140
    • 0034799113 scopus 로고    scopus 로고
    • Ninety patients with non-alcoholic steatohepatitis. Insulin resistance, familial tendency, and severity of disease
    • Willner IR, Waters B, Patil SR. Ninety patients with non-alcoholic steatohepatitis. insulin resistance, familial tendency, and severity of disease. Am J Gastroenterol 2001; 96: 2957-2961.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2957-2961
    • Willner, I.R.1    Waters, B.2    Patil, S.R.3
  • 141
    • 0014051568 scopus 로고
    • Liver morphology and function tests in obesity and during total starvation
    • Rrozental P, Biava C, Spencer H, Zimmerman HJ. Liver morphology and function tests in obesity and during total starvation. Am J Dig Dis 1967; 12: 198-208.
    • (1967) Am J Dig Dis , vol.12 , pp. 198-208
    • Rrozental, P.1    Biava, C.2    Spencer, H.3    Zimmerman, H.J.4
  • 142
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91-100.
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 143
    • 0014937883 scopus 로고
    • Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small bowel bypass
    • Drenick EJ, Simmons F, Murphy JF. Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small bowel bypass. N Engl J Med 1970; 282: 829-834.
    • (1970) N Engl J Med , vol.282 , pp. 829-834
    • Drenick, E.J.1    Simmons, F.2    Murphy, J.F.3
  • 144
    • 0033119425 scopus 로고    scopus 로고
    • The ratio of aspartate aminotransferase to alanine aminotransferase: Potential value in differentiating non-alcoholic steatohepatitis from alcoholic liver disease
    • Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating non-alcoholic steatohepatitis from alcoholic liver disease. Am J Gastroenterol 1999; 94: 1018-1022.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1018-1022
    • Sorbi, D.1    Boynton, J.2    Lindor, K.D.3
  • 145
    • 0022492463 scopus 로고
    • Nonalcoholic steatohepatitis in obesity: A reversible condition
    • Eriksson S, Eriksson KF, Bondesson L. Nonalcoholic steatohepatitis in obesity: a reversible condition. Acta Med Scand 1986; 220: 83-88.
    • (1986) Acta Med Scand , vol.220 , pp. 83-88
    • Eriksson, S.1    Eriksson, K.F.2    Bondesson, L.3
  • 146
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese subjects
    • Andersen T, Gluud C, Franzmann MB, Christoffersen P. Hepatic effects of dietary weight loss in morbidly obese subjects. J Hepatol 1991; 12: 224-229.
    • (1991) J Hepatol , vol.12 , pp. 224-229
    • Andersen, T.1    Gluud, C.2    Franzmann, M.B.3    Christoffersen, P.4
  • 147
    • 0034068984 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Association with obesity and insulin resistance, and influence of weight loss
    • Luyckx FH, Lefebre PJ, Scheen AJ. Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. Diabetes Metab 2000; 26: 98-106.
    • (2000) Diabetes Metab , vol.26 , pp. 98-106
    • Luyckx, F.H.1    Lefebre, P.J.2    Scheen, A.J.3
  • 148
    • 0023253921 scopus 로고
    • Steatosis and cirrhosis in an obese diabetic. Resolution of fatty liver by fasting
    • Keeffe EB, Adesman PW, Stenzel P, Palmer RM. Steatosis and cirrhosis in an obese diabetic. Resolution of fatty liver by fasting. Dig Dis Sci 1987; 32: 441-445.
    • (1987) Dig Dis Sci , vol.32 , pp. 441-445
    • Keeffe, E.B.1    Adesman, P.W.2    Stenzel, P.3    Palmer, R.M.4
  • 149
    • 0028022928 scopus 로고
    • Persistent hyperaminotransferasemia resolving after weight reduction in obese children
    • Vajro P, Fontanella A, Perna C, Orso G, Tedesco M, De Vincenzo A. Persistent hyperaminotransferasemia resolving after weight reduction in obese children. J Pediatr 1994; 125: 239-241.
    • (1994) J Pediatr , vol.125 , pp. 239-241
    • Vajro, P.1    Fontanella, A.2    Perna, C.3    Orso, G.4    Tedesco, M.5    De Vincenzo, A.6
  • 151
    • 0028998719 scopus 로고
    • Regression of hepatic steatosis in morbidly obese persons after gastric bypass
    • Silverman EM, Sapala JA, Appelman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol 1995; 104: 23-31.
    • (1995) Am J Clin Pathol , vol.104 , pp. 23-31
    • Silverman, E.M.1    Sapala, J.A.2    Appelman, H.D.3
  • 154
    • 0002746060 scopus 로고    scopus 로고
    • Dietary lecithin, anti-oxidant and vitamin B complex (LAB) decrease hepatic steatosis in patients with NASH
    • Fu CS, Esrason K, Alshak NS, Conteas CN, Simmons VJ. Dietary lecithin, anti-oxidant and vitamin B complex (LAB) decrease hepatic steatosis in patients with NASH. Gastroenterology 1998; 114: A1243.
    • (1998) Gastroenterology , vol.114
    • Fu, C.S.1    Esrason, K.2    Alshak, N.S.3    Conteas, C.N.4    Simmons, V.J.5


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