Redox control of endoplasmic reticulum function

Antioxidants and Redox Signaling

Volumn 13, Issue 1, 2010, Pages 77-108

  Csala, Miklós ^a   Margittai, Éiva ^a   Bánhegyi, Gábor ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA MANNOSIDASE; ASCORBIC ACID; CASPASE 12; DEHYDROASCORBIC ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BCL 2; PYRIDINE NUCLEOTIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TOCOPHEROL; VITAMIN K GROUP;

APOPTOSIS; AUTOPHAGY; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL FUNCTION; CYTOSOL; DEGENERATIVE DISEASE; DISULFIDE BOND; ELECTRON TRANSPORT; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GLYCOGENOLYSIS; HUMAN; HYPOXIA; ISCHEMIA; MEMBRANE TRANSPORT; METABOLIC DISORDER; NEOPLASM; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REPERFUSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ENDOPLASMIC RETICULUM; HOMEOSTASIS; HUMANS; OXIDATION-REDUCTION;

EID: 77952964587     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.2529     Document Type: Review

References (342)

1. Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, De-gen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, Sharp FR, and Kuan CY. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol 169: 566-583, 2006.
2. Adhami F, Schloemer A, and Kuan CY. The roles of au-tophagy in cerebral ischemia. Autophagy 3: 42-44, 2007.
3. Althausen S, Mengesdorf T, Mies G, Olah L, Nairn AC, Proud CG, and Paschen W. Changes in the phosphoryla-tion of initiation factor eIF-2a, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. J Neurochem 78: 779-787, 2001.
4. Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Ca-merini S, Mezghrani A, Ruffato E, Simmen T, and Sitia R. Thiol-mediated protein retention in the endoplasmic retic-ulum: The role of ERp44. EMBO J 22: 5015-5022, 2003.
5. Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, and Sitia R. ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J 21: 835-844, 2002.
6. Anelli T and Sitia R. Protein quality control in the early secretory pathway. EMBO J 27: 315-327, 2008.
7. Appenzeller-Herzog C and Ellgaard L. The human PDI family: Versatility packed into a single fold. Biochim Biophys Acta 1783: 535-548, 2008.
8. Appenzeller-Herzog C, Riemer J, Christensen B, Sorensen ES, and Ellgaard L. A novel disulfide switch mechanism in Ero1a balances ER oxidation in human cells. EMBO J 27: 2977-2987, 2008.
9. Atkin JD, Farg MA, Turner BJ, Tomas D, Lysaght JA, Nu-nan J, Rembach A, Nagley P, Beart PM, Cheema SS, and Horne MK. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. J Biol Chem 281: 30152-30165, 2006.
10. Atkin JD, Farg MA, Walker AK, McLean C, Tomas D, and Horne MK. Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyo-trophic lateral sclerosis. Neurobiol Dis 30: 400-407, 2008.
11. Baines AC and Zhang B. Receptor-mediated protein transport in the early secretory pathway. Trends Biochem Sci 32: 381-388, 2007.
12. Baker KM, Chakravarthi S, Langton KP, Sheppard AM, Lu H, and Bulleid NJ. Low reduction potential of Ero1a regulatory disulfides ensures tight control of substrate oxidation. EMBO J 27: 2988-2997, 2008.
13. 2\+ release channel has an oxidoreductase-like domain. Proc Natl Acad Sci USA 99: 12155-12160, 2002.
14. Bando Y, Katayama T, Kasai K, Taniguchi M, Tamatani M, and Tohyama M. GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia= reperfusion injury. Eur J Neurosci 18: 829-840, 2003.
15. Banhegyi G, Benedetti A, Csala M, and Mandl J. Stress on redox. FEBS Lett 581: 3634-3640, 2007.
16. Banhegyi G, Benedetti A, Fulceri R, and Senesi S. Co-operativity between 11b-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J Biol Chem 279: 27017-27021, 2004.
17. Banhegyi G, Braun L, Csala M, Puskas F, and Mandl J. Ascorbate metabolism and its regulation in animals. Free Radic Biol Med 23: 793-803, 1997.
18. Banhegyi G, Csala M, and Benedetti A. Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endopsmic reticulum. J Mol Endocrinol 42: 283-289, 2009.
19. Banhegyi G, Csala M, Braun L, Garzo T, and Mandl J. Ascorbate synthesis-dependent glutathione consumption in mouse liver. FEBS Lett 381: 39-41, 1996.
20. Banhegyi G, Lusini L, Puskas F, Rossi R, Fulceri R, Braun L, Mile V, di Simplicio P, Mandl J, and Benedetti A. Preferential transport of glutathione versus glutathione dis-ulfide in rat liver microsomal vesicles. J Biol Chem 274: 12213-12216, 1999.
21. Banhegyi G, Mandl J, and Csala M. Redox-based endo-plasmic reticulum dysfunction in neurological diseases. J Neurochem 107: 20-34, 2008.
22. Banhegyi G, Marcolongo P, Puskas F, Fulceri R, Mandl J, and Benedetti A. Dehydroascorbate and ascorbate transport in rat liver microsomal vesicles. J Biol Chem 273: 2758-2762, 1998. (Pubitemid 28133921)
23. Bass R, Ruddock LW, Klappa P, and Freedman RB. A major fraction of endoplasmic reticulum-located glutathione is present as mixed disulfides with protein. J Biol Chem 279: 5257-5262, 2004.
24. Baumeister P, Dong D, Fu Y, and Lee AS. Transcriptional induction of GRP78=BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol Cancer Ther 8: 1086-1094, 2009.
25. Bedard K, Szabo E, Michalak M, and Opas M. Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57. Int Rev Cytol 245: 91-121, 2005.
26. Belkaid A, Copland IB, Massillon D, and Annabi B. Silencing of the human microsomal glucose-6-phosphate trans-locase induces glioma cell death: Potential new anticancer target for curcumin. FEBS Lett 580: 3746-3752, 2006.
27. Belkaid A, Currie JC, Desgagnes J, and Annabi B. The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Cancer Cell Int 6: 7, 2006.
28. Belousov VV, Fradkov AF, Lukyanov KA, Staroverov DB, Shakhbazov KS, Terskikh AV, and Lukyanov S. Genetically encoded fluorescent indicator for intracellular hydrogen peroxide. Nat Methods 3: 281-286, 2006.
29. Benavides A, Pastor D, Santos P, Tranque P, and Calvo S. CHOP plays a pivotal role in the astrocyte death induced by oxygen and glucose deprivation. Glia 52: 261-275, 2005.
30. Bence NF, Sampat RM, and Kopito RR. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555, 2001.
31. Berndt C, Lillig CH, and Holmgren A. Thioredoxins and glutaredoxins as facilitators of protein folding. Biochim Biophys Acta 1783: 641-650, 2008.
32. Bezprozvanny I, and Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci 31: 454-463, 2008.
33. Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, and Koumenis C. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 24: 3470-3481, 2005.
34. Bjorneboe A, Bjorneboe GE, and Drevon CA. Absorption, transport and distribution of vitamin E. J Nutr 120: 233-242, 1990.
35. Bock KW and Kohle C. Topological aspects of oligomeric UDP-glucuronosyltransferases in endoplasmic reticulum membranes: Advances and open questions. Biochem Pharmacol 77: 1458-2146, 2009.
36. Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH, Jr., Price DL, Sisodia SS, and Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci USA 91: 8292-8296, 1994.
37. Bowling AC, Barkowski EE, McKenna-Yasek D, Sapp P, Horvitz HR, Beal MF, and Brown RH, Jr. Superoxide dis-mutase concentration and activity in familial amyotrophic lateral sclerosis. J Neurochem 64: 2366-2369, 1995.
38. Brady NR, Hamacher-Brady A, Yuan H, and Gottlieb RA. The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco= endoplasmic reticulum calcium stores. FEBS J 274: 3184-3197, 2007.
39. Bruijn LI, Miller TM, and Cleveland DW. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 27: 723-749, 2004.
40. Bublitz C and Lawler CA. The levels of nicotinamide nu-cleotides in liver microsomes and their possible significance to the function of hexose phosphate dehydrogenase. Bio-chem J 245: 263-267, 1987.
41. Buettner GR. The pecking order of free radicals and anti-oxidants: Lipid peroxidation, a-tocopherol, and ascorbate. Arch Biochem Biophys 300: 535-543, 1993.
42. Cabibbo A, Pagani M, Fabbri M, Rocchi M, Farmery MR, Bulleid NJ, and Sitia R. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticu-lum. J Biol Chem 275: 4827-4833, 2000.
43. Camporeale G and Zempleni J. Oxidative folding of inter-leukin-2 is impaired in flavin-deficient jurkat cells, causing intracellular accumulation of interleukin-2 and increased expression of stress response genes. J Nutr 133: 668-672, 2003.
44. Cannon MB and Remington SJ. Redox-sensitive green fluorescent protein: Probes for dynamic intracellular redox responses. A review. Methods Mol Biol 476: 51-65, 2008.
45. Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, Tonon G, and DePinho RA. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11: 349-360, 2007.
46. Cenci S and Sitia R. Managing and exploiting stress in the antibody factory. FEBS Lett 581: 3652-3657, 2007.
47. Chou JY, Matern D, Mansfield BC, and Chen YT. Type I glycogen storage diseases: Disorders of the glucose-6-phosphatase complex. Curr Mol Med 2: 121-143, 2002.
48. Clarke JL and Mason PJ. Murine hexose-6-phosphate de-hydrogenase: A bifunctional enzyme with broad substrate specificity and 6- phosphogluconolactonase activity. Arch Biochem Biophys 415: 229-234, 2003.
49. Clerc S, Hirsch C, Oggier DM, Deprez P, Jakob C, Sommer T, and Aebi M. Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum. J Cell Biol 184: 159-172, 2009.
50. Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, and Lindquist S. a-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313: 324-328, 2006.
51. Cribb AE, Peyrou M, Muruganandan S, and Schneider L. The endoplasmic reticulum in xenobiotic toxicity. Drug Metab Rev 37: 405-442, 2005.
52. Cunha DA, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, and Cnop M. Initiation and execution of lipotoxic ER stress in pancreatic b-cells. J Cell Sci 121: 2308-2318, 2008.
53. Cuozzo JW and Kaiser CA. Competition between gluta-thione and protein thiols for disulfide-bond formation. Nat Cell Biol 1: 130-135, 1999.
54. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, and Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23: 7198-7209, 2003.
55. Cullinan SB and Diehl JA. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 279: 20108-20117, 2004.
56. Czegle I, Piccirella S, Senesi S, Csala M, Mandl J, Banhegyi G, Fulceri R, and Benedetti A. Cooperativity between 11b-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. Mol Cell Endocrinol 248: 24-25, 2006.
57. Czyzyk-Krzeska MF. Molecular aspects of oxygen sensing in physiological adaptation to hypoxia. Respir Physiol 110: 99-111, 1997.
58. Csala M, Banhegyi G, and Benedetti A. Endoplasmic re-ticulum: A metabolic compartment. FEBS Lett 580: 2160-2165, 2006.
59. Csala M, Banhegyi G, Braun L, Szirmai R, Burchell A, Burchell B, Benedetti A, and Mandl J. b-Glucuronidase latency in isolated murine hepatocytes. Biochem Pharmacol 59: 801-805, 2000.
60. Csala M, Braun L, Mile V, Kardon T, Szarka A, Kupcsulik P, Mandl J, and Banhegyi G. Ascorbate-mediated electron transfer in protein thiol oxidation in the endoplasmic re-ticulum. FEBS Lett 460: 539-543, 1999.
61. Csala M, Marcolongo P, Lizak B, Senesi S, Margittai E, Fulceri R, Magyar JE, Benedetti A, and Banhegyi G. Transport and transporters in the endoplasmic reticulum. Biochim Biophys Acta 1768: 1325-1341, 2007.
62. Csala M, Mile V, Benedetti A, Mandl J, and Banhegyi G. Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles. Biochem J 349: 413-415, 2000.
63. Csala M, Szarka A, Margittai E, Mile V, Kardon T, Braun L, Mandl J, and Banhegyi G. Role of vitamin E in ascorbate-dependent protein thiol oxidation in rat liver endoplasmic reticulum. Arch Biochem Biophys 388: 55-59, 2001.
64. Danielson SR and Andersen JK. Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med 44: 1787-1794, 2008.
65. DeGracia DJ and Montie HL. Cerebral ischemia and the unfolded protein response. J Neurochem 91: 1-8, 2004.
66. Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP, and et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261: 1047-1051, 1993.
67. Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, and Ron D. Translational repression mediates activation of nuclear factor k B by phosphorylated translation initiation factor 2. Mol Cell Biol 24: 10161-10168, 2004.
68. Denton RM, Yorke RE, and Randle PJ. Measurement of concentrations of metabolites in adipose tissue and effects of insulin, alloxan-diabetes and adrenaline. Biochem J 100: 407-419, 1966.
69. Dixon BM, Heath SH, Kim R, Suh JH, and Hagen TM. Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation. Anti-oxid Redox Signal 10: 963-972, 2008.
70. Dollins DE, Warren JJ, Immormino RM, and Gewirth DT. Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones. Mol Cell 28: 41-56, 2007.
71. Draper N and Stewart PM. 11b-hydroxysteroid dehydro-genase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol 186: 251-271, 2005.
72. Duennwald ML, and Lindquist S. Impaired ERAD and ER stress are early and specific events in polyglutamine tox-icity. Genes Dev 22: 3308-3319, 2008.
73. \+ and is stimulated by extracellular glucose. Mol Cell Endocrinol 301: 137-141, 2009.
74. Ellgaard L and Ruddock LW. The human protein disulfide isomerase family: Substrate interactions and functional properties. EMBO Rep 6: 28-32, 2005.
75. Fagioli C, Mezghrani A, and Sitia R. Reduction of interchain disulfide bonds precedes the dislocation of Ig-m chains from the endoplasmic reticulum to the cytosol for proteasomal degradation. J Biol Chem 276: 40962-40967, 2001.
76. Feng W, Liu G, Allen PD, and Pessah IN. Transmembrane redox sensor of ryanodine receptor complex. J Biol Chem 275: 35902-35907, 2000.
77. Ferreiro E, Resende R, Costa R, Oliveira CR, and Pereira CM. An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-b peptides neurotoxicity. Neurobiol Dis 23: 669-678, 2006.
78. Fischer H, Koenig U, Eckhart L, and Tschachler E. Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun 293: 722-726, 2002.
79. Fraldi A, Zito E, Annunziata F, Lombardi A, Cozzolino M, Monti M, Spampanato C, Ballabio A, Pucci P, Sitia R, and Cosma MP. Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum Mol Genet 17: 2610-2621, 2008.
80. Frand AR and Kaiser CA. The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum. Mol Cell 1: 161-170, 1998.
81. Fujimoto T, Ohsaki Y, Cheng J, Suzuki M, and Shinohara Y. Lipid droplets: A classic organelle with new outfits. His-tochem Cell Biol 130: 263-279, 2008.
82. Fujimoto T, Onda M, Nagai H, Nagahata T, Ogawa K, and Emi M. Upregulation and overexpression of human X-box binding protein 1 (hXBP-1) gene in primary breast cancers. Breast Cancer 10: 301-306, 2003.
83. Garcia AA and Reitsma PH. VKORC1 and the vitamin K cycle. Vitam Horm 78: 23-33, 2008.
84. Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirch-gessner TG, and Lusis AJ. The unfolded protein response is an important regulator of inflammatory genes in endo-thelial cells. Arterioscler Thromb Vasc Biol 26: 2490-2496, 2006.
85. Gerin I and Van Schaftingen E. Evidence for glucose-6-phosphate transport in rat liver microsomes. FEBS Lett 517: 257-260, 2002.
86. Gerin I, Veiga-da-Cunha M, Achouri Y, Collet JF, and Van Schaftingen E. Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. FEBS Lett 419: 235-238, 1997.
87. Gess B, Hofbauer KH, Wenger RH, Lohaus C, Meyer HE, and Kurtz A. The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-La. Eur J Biochem 270: 2228-2235, 2003. (Pubitemid 36605572)
88. Ghosh D. Human sulfatases: A structural perspective to catalysis. Cell Mol Life Sci 64: 2013-2022, 2007.
89. Glembotski CC. Endoplasmic reticulum stress in the heart. Circ Res 101: 975-984, 2007.
90. Glembotski CC. The role of the unfolded protein response in the heart. J Mol Cell Cardiol 44: 453-459, 2008.
91. Gooding JM, Shayeghi M, and Saggerson ED. Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes. Eur J Biochem 271: 954-961, 2004.
92. Gregor MF and Hotamisligil GS. Thematic review series: Adipocyte Biology. Adipocyte stress: The endoplasmic re-ticulum and metabolic disease. J Lipid Res 48: 1905-1914, 2007.
93. Gross E, Sevier CS, Heldman N, Vitu E, Bentzur M, Kaiser CA, Thorpe C, and Fass D. Generating disulfides enzy-matically: Reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p. Proc Natl Acad Sci USA 103: 299-304, 2006.
94. Guerre-Millo M. Adiponectin: Aan update. Diabetes Metab 34: 12-18, 2008.
95. Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, and Mattson MP. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid b-peptide: involvement of calcium and oxyradicals. J Neurosci 17: 4212-4222, 1997.
96. Gustafsson AB and Gottlieb RA. Autophagy in ischemic heart disease. Circ Res 104: 150-158, 2009.
97. Halliwell B. Oxidative stress and neurodegeneration: Where are we now? J Neurochem 97: 1634-1658, 2006.
98. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, and Papa FR. IRE1a kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138: 562-575, 2009
99. Hartl FU. Molecular chaperones in cellular protein folding. Nature 381: 571-579, 1996.
100. Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Dodd RL, and Chan PH. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxi-dative stress in ischemic neurons. J Cereb Blood Flow Metab 25: 41-53, 2005.
101. Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Dodd RL, Nishi T, Maier CM, Kinouchi H, and Chan PH. Oxidative damage to the endoplasmic reticulum is implicated in is-chemic neuronal cell death. J Cereb Blood Flow Metab 23: 1117-1128, 2003.
102. He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, and Alam J. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 276: 20858-20865, 2001.
103. Heath-Engel HM, Chang NC, and Shore GC. The endo-plasmic reticulum in apoptosis and autophagy: Role of the BCL-2 protein family. Oncogene 27: 6419-6433, 2008.
104. Hebert DN and Molinari M. In and out of the ER: Protein folding, quality control, degradation, and related human diseases. Physiol Rev 87: 1377-1408, 2007.
105. Heckler EJ, Rancy PC, Kodali VK, and Thorpe C. Generating disulfides with the Quiescin-sulfhydryl oxidases. Biochim Biophys Acta 1783: 567-577, 2008.
106. Henrich M and Buckler KJ. Effects of anoxia and aglycae-mia on cytosolic calcium regulation in rat sensory neurons. J Neurophysiol 100: 456-473, 2008.
107. Heritage D and Wonderlin WF. Translocon pores in the endoplasmic reticulum are permeable to a neutral, polar molecule. J Biol Chem 276: 22655-22662, 2001.
108. Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, An-tonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, and Korsmeyer SJ. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1a. Science 312: 572-576, 2006.
109. Hewitt KN, Walker EA, and Stewart PM. Minireview: Hexose-6-phosphate dehydrogenase and redox control of 11b-hydroxysteroid dehydrogenase type 1 activity. Endocrinology 146: 2539-2543, 2005.
110. Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, and Mikoshiba K. Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell 120: 85-98, 2005.
111. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, and Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature 420: 333-336, 2002.
112. Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, and Tohyama M. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Ab-induced cell death. J Cell Biol 165: 347-356, 2004.
113. Hoffmann F and Maser E. Carbonyl reductases and plu-ripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase=reductase superfamily. Drug Metab Rev 39: 87-144, 2007.
114. Holmes MC, Yau JL, Kotelevtsev Y, Mullins JJ, and Seckl JR. 11 b-Hydroxysteroid dehydrogenases in the brain: Two enzymes two roles. Ann NY Acad Sci 1007: 357-366, 2003.
115. Holtz WA and O'Malley KL. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopami-nergic neurons. J Biol Chem 278: 19367-19377, 2003.
116. Holtz WA, Turetzky JM, Jong YJ, and O'Malley KL. Oxi-dative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics. J Neurochem 99: 54-69, 2006.
117. Hoozemans JJ, van Haastert ES, Eikelenboom P, de Vos RA, Rozemuller JM, and Scheper W. Activation of the unfolded protein response in Parkinson's disease. Biochem Biophys Res Commun 354: 707-711, 2007.
118. Hoozemans JJ, Stieler J, van Haastert ES, Veerhuis R, Rozemuller AJ, Baas F, Eikelenboom P, Arendt T, and Scheper W. The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis. Exp Gerontol 41: 380-386, 2006.
119. Hoozemans JJ, Veerhuis R, Van Haastert ES, Rozemuller JM, Baas F, Eikelenboom P, and Scheper W. The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol 110: 165-172, 2005.
120. Horemans N, Foyer CH, and Asard H. Transport and action of ascorbate at the plant plasma membrane. Trends Plant Sci 5: 263-267, 2000.
121. Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, and Mizushima T. Endoplasmic reticulum chaperones inhibit the production of amyloid-b peptides. Biochem J 402: 581-589, 2007.
122. Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, and Shimomura I. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56: 901-911, 2007.
123. Hosokawa N and Nagata K. Procollagen binds to both prolyl 4-hydroxylase=protein disulfide isomerase and HSP47 within the endoplasmic reticulum in the absence of ascorbate. FEBS Lett 466: 19-25, 2000.
124. Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 Suppl 2: S73-78, 2005.
125. Hou ZQ, Li HL, Gao L, Pan L, Zhao JJ, and Li GW. Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Mol Cell Endocrinol 291: 71-78, 2008.
126. Hoyer-Hansen M and Jaattela M. Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14: 1576-1582, 2007.
127. Hu P, Han Z, Couvillon AD, Kaufman RJ, and Exton JH. Autocrine tumor necrosis factor a links endoplasmic retic-ulum stress to the membrane death receptor pathway through IRE1a-mediated NF-kB activation and down-regulation of TRAF2 expression. Mol Cell Biol 26: 3071-3084, 2006.
128. Hwang C, Sinskey AJ, and Lodish HF. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257: 1496-1502, 1992.
129. Iadecola C, Zhang F, Casey R, Nagayama M, and Ross ME. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide syn-thase gene. J Neurosci 17: 9157-9164, 1997.
130. Ilieva EV, Ayala V, Jove M, Dalfo E, Cacabelos D, Pove-dano M, Bellmunt MJ, Ferrer I, Pamplona R, and Portero-Otin M. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 130: 3111-3123, 2007.
131. Iyanagi T. Molecular mechanism of phase I and phase II drug-metabolizing enzymes: Implications for detoxification. Int Rev Cytol 260: 35-112, 2007.
132. Jakubowski H. Molecular basis of homocysteine toxicity in humans. Cell Mol Life Sci 61: 470-487, 2004.
133. Jamora C, Dennert G, and Lee AS. Inhibition of tumor progression by suppression of stress protein GRP78=BiP induction in fibrosarcoma B=C10ME. Proc Natl Acad Sci USA 93: 7690-7694, 1996.
134. Ji C. Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol He-patol 23 Suppl 1: S16-24, 2008.
135. Ji C and Kaplowitz N. ER stress: Can the liver cope? J Hepatol 45: 321-333, 2006.
136. Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, and Wek RC. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol 24: 1365-1377, 2004.
137. Kadowaki H, Nishitoh H, Urano F, Sadamitsu C, Matsu-zawa A, Takeda K, Masutani H, Yodoi J, Urano Y, Nagano T, and Ichijo H. Amyloid b induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ 12: 19-24, 2005.
138. Kamata H, Honda S, Maeda S, Chang L, Hirata H, and Karin M. Reactive oxygen species promote TNFa-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-661, 2005.
139. Kanehara K, Kawaguchi S, and Ng DT. The EDEM and Yos9p families of lectin-like ERAD factors. Semin Cell Dev Biol 18: 743-750, 2007.
140. Kanekura K, Suzuki H, Aiso S, and Matsuoka M. ER stress and unfolded protein response in amyotrophic lateral sclerosis. Mol Neurobiol 39: 81-89, 2009.
141. Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Mat-suoka TA, Matsuhisa M, and Yamasaki Y. Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic b-cell dysfunction and insulin resistance. Int J Biochem Cell Biol 38: 782-793, 2006.
142. Kaplowitz N. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis 22: 137-144, 2002.
143. Karala AR, Lappi AK, Saaranen M, and Ruddock LW. Efficient peroxide mediated oxidative refolding of a protein at physiological pH and implications for oxidative folding in the endoplasmic reticulum. Antioxid Redox Signal 11: 963-970, 2009.
144. Kardon T, Senesi S, Marcolongo P, Legeza B, Banhegyi G, Mandl J, Fulceri R, and Benedetti A. Maintenance of lu-minal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. FEBS Lett 582: 1809-1815, 2008.
145. Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, and Eizirik DL. Free fatty acids and cytokines induce pancreatic b-cell apoptosis by different mechanisms: Role of nuclear factor-kB and endoplasmic reticulum stress. Endocrinology 145: 5087-5096, 2004.
146. nd, and Przedborski S. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci USA 103: 6025-6030, 2006.
147. Kim I, Xu W, and Reed JC. Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7: 1013-1030, 2008.
148. Kim SJ, Zhang Z, Hitomi E, Lee YC, and Mukherjee AB. Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL. Hum Mol Genet 15: 1826-1834, 2006.
149. Kim YK, Kim KS, and Lee AS. Regulation of the glucose-regulated protein genes by b-mercaptoethanol requires de novo protein synthesis and correlates with inhibition of protein glycosylation. J Cell Physiol 133: 553-559, 1987.
150. Kimata Y, Oikawa D, Shimizu Y, Ishiwata-Kimata Y, and Kohno K. A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J Cell Biol 167: 445-456, 2004.
151. Kiuchi K, Nishikimi M, and Yagi K. Purification and characterization of L-gulonolactone oxidase from chicken kidney microsomes. Biochemistry 21: 5076-5082, 1982.
152. Kivirikko KI, Myllyla R, and Pihlajaniemi T. Protein hy-droxylation: Prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit. FASEB J 3: 1609-1617, 1989.
153. Klivenyi P, Siwek D, Gardian G, Yang L, Starkov A, Cleren C, Ferrante RJ, Kowall NW, Abeliovich A, and Beal MF. Mice lacking a-synuclein are resistant to mitochondrial toxins. Neurobiol Dis 21: 541-548, 2006.
154. Koch HG, Goebeler M, Marquardt T, Roth J, and Harms E. The redox status of aminothiols as a clue to homocysteine-induced vascular damage? Eur J Pediatr 157: S102-106, 1998.
155. Kohno K, Higuchi T, Ohta S, Kohno K, Kumon Y, and Sakaki S. Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil. Neurosci Lett 224: 17-20, 1997.
156. Kondo S, Murakami T, Tatsumi K, Ogata M, Kanemoto S, Otori K, Iseki K, Wanaka A, and Imaizumi K. OASIS, a CREB=ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol 7: 186-194, 2005.
157. Kondo S, Saito A, Hino S, Murakami T, Ogata M, Kane-moto S, Nara S, Yamashita A, Yoshinaga K, Hara H, and Imaizumi K. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol Cell Biol 27: 1716-1729, 2007.
158. Koumenis C and Wouters BG. "Translating" tumor hyp-oxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol Cancer Res 4: 423-436, 2006.
159. Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, and DeGracia DJ. Brain ischemia and reperfu-sion activates the eukaryotic initiation factor 2a kinase, PERK. J Neurochem 77: 1418-1421, 2001.
160. Kuwabara K, Matsumoto M, Ikeda J, Hori O, Ogawa S, Maeda Y, Kitagawa K, Imuta N, Kinoshita T, Stern DM, Yanagi H, and Kamada T. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J Biol Chem 271: 5025-5032, 1996.
161. 2\+ binding site on GRP78 is differentially enhanced by ADP and ATP. J Biol Chem 281: 8796-8805, 2006.
162. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, and Vandenabeele P. Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 44-55, 2007.
163. Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, and Bunn HF. Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem 283: 29285-29291, 2008.
164. Larade K, Jiang ZG, Dejam A, Zhu H, and Bunn HF. The reductase NCB5OR is responsive to the redox status in b-cells and is not involved in the ER stress response. Bio-chem J 404: 467-476, 2007.
165. Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, Shackleton CH, Parker KL, White PC, and Stewart PM. Hexose-6-phosphate dehydrogenase knock-out mice lack 11b-hydroxysteroid dehydrogenase type 1-mediated glu-cocorticoid generation. J Biol Chem 281: 6546-6551, 2006.
166. Lavery GG, Walker EA, Turan N, Rogoff D, Ryder JW, Shelton JM, Richardson JA, Falciani F, White PC, Stewart PM, Parker KL, and McMillan DR. Deletion of
167. Lavoie C and Paiement J. Topology of molecular machines of the endoplasmic reticulum: A compilation of proteomics and cytological data. Histochem Cell Biol 129: 117-128, 2008.
168. Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, and Biden TJ. Endoplasmic reticulum stress contributes to b cell apoptosis in type 2 diabetes. Diabetologia 50: 752-763, 2007.
169. Lee AS. GRP78 induction in cancer: Therapeutic and prognostic implications. Cancer Res 67: 3496-3499, 2007.
170. Lentz SR. Mechanisms of homocysteine-induced athero-thrombosis. J Thromb Haemost 3: 1646-1654, 2005.
171. Leuzzi R, Banhegyi G, Kardon T, Marcolongo P, Capecchi PL, Burger HJ, Benedetti A, and Fulceri R. Inhibition of microsomal glucose-6-phosphate transport in human neu-trophils results in apoptosis: A potential explanation for neutrophil dysfunction in glycogen storage disease type 1b. Blood 101: 2381-2387, 2003.
172. 2\+-dependent redox modulation of SERCA 2b by ERp57. J Cell Biol 164: 35-46, 2004.
173. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, and Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-a and interleukin-6: Model of NF-kB-and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem 280: 21763-21772, 2005.
174. Li Z and Srivastava PK. Tumor rejection antigen gp96= grp94 is an ATPase: implications for protein folding and antigen presentation. EMBO J 12: 3143-3151, 1993.
175. Lin JH, Li H, Zhang Y, Ron D, and Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. PLoS ONE 4: e4170. 2009.
176. Lin MT and Beal MF. Mitochondrial dysfunction and oxi-dative stress in neurodegenerative diseases. Nature 443: 787-795, 2006.
177. Lindholm D, Wootz H, and Korhonen L. ER stress and neu-rodegenerative diseases. Cell Death Differ 13: 385-392, 2006.
178. Linster CL and Van Schaftingen E. Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J 274: 1-22, 2007.
179. Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, and Hetz C. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1a. Mol Cell 33: 679-691, 2009.
180. Little E, Ramakrishnan M, Roy B, Gazit G, and Lee AS. The glucose-regulated proteins (GRP78 and GRP94): Functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr 4: 1-18, 1994.
181. Liu D, Bao F, Wen J, and Liu J. Mutation of superoxide dismutase elevates reactive species: Comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis. Neu-roscience 146: 255-264, 2007.
182. Liu Q, Berchner-Pfannschmidt U, Moller U, Brecht M, Wotzlaw C, Acker H, Jungermann K, and Kietzmann T. A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression. Proc Natl Acad Sci USA 101: 4302-4307, 2004.
183. Lizak B, Czegle I, Csala M, Benedetti A, Mandl J, and Banhegyi G. Translocon pores in the endoplasmic reticu-lum are permeable to small anions. Am J Physiol Cell Physiol 291: C511-517, 2006.
184. Lizak B, Csala M, Benedetti A, and Banhegyi G. The trans-locon and the non-specific transport of small molecules in the endoplasmic reticulum. Mol Membr Biol 25: 95-101, 2008.
185. Lundstrom-Ljung J, Birnbach U, Rupp K, Soling HD, and Holmgren A. Two resident ER-proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: Comparison with protein disulfide isomerase. FEBS Lett 357: 305-308, 1995.
186. Luu-The V. Analysis and characteristics of multiple types of human 17b-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol 76: 143-151, 2001.
187. Ma Y, Brewer JW, Diehl JA, and Hendershot LM. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318: 1351-1365, 2002.
188. Magyar JE, Gamberucci A, Konta L, Margittai E, Mandl J, Banhegyi G, Benedetti A, and Csala M. Endoplasmic re-ticulum stress underlying the pro-apoptotic effect of epi-gallocatechin gallate in mouse hepatoma cells. Int J Biochem Cell Biol 41: 694-700, 2009.
189. Malhotra JD and Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword? Antioxid Redox Signal 9: 2277-2293, 2007.
190. Manthey KC, Chew YC, and Zempleni J. Riboflavin deficiency impairs oxidative folding and secretion of apolipo-protein B-100 in HepG2 cells, triggering stress response systems. J Nutr 135: 978-982, 2005.
191. Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, and Cnop M. The endoplasmic reticulum in pancreatic b cells of type 2 diabetes patients. Diabetologia 50: 2486-2494, 2007.
192. Marciniak SJ and Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149, 2006.
193. Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, and Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18: 3066-3077, 2004.
194. Marcolongo P, Piccirella S, Senesi S, Wunderlich L, Gerin I, Mandl J, Fulceri R, Banhegyi G, and Benedetti A. The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11b-hydroxysteroid dehydrogenase type 1 system of the adipose tissue. Endocrinology 148: 2487-2495, 2007.
195. Marcolongo P, Senesi S, Gava B, Fulceri R, Sorrentino V, Margittai E, Lizak B, Csala M, Banhegyi G, and Benedetti A. Metyrapone prevents cortisone-induced preadipocyte differentiation by depleting luminal NADPH of the endo-plasmic reticulum. Biochem Pharmacol 76: 382-390, 2008.
196. Margittai E and Banhegyi G. Isocitrate dehydrogenase: A NADPH-generating enzyme in the lumen of the endo-plasmic reticulum. Arch Biochem Biophys 471: 184-190, 2008.
197. Margittai E, Banhegyi G, Kiss A, Nagy G, Mandl J, Schaff Z, and Csala M. Scurvy leads to endoplasmic reticulum stress and apoptosis in the liver of Guinea pigs. J Nutr 135: 2530-2534, 2005.
198. Margittai E, Low P, Szarka A, Csala M, Benedetti A, and Banhegyi G. Intraluminal hydrogen peroxide induces a permeability change of the endoplasmic reticulum membrane. FEBS Lett 582: 4131-4136, 2008.
199. Mariappan M, Radhakrishnan K, Dierks T, Schmidt B, and von Figura K. ERp44 mediates a thiol-independent retention of formylglycine-generating enzyme in the endoplas-mic reticulum. J Biol Chem 283: 6375-6383, 2008.
200. Marinho HS, Antunes F, and Pinto RE. Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophospholipid hydro-peroxides. Free Radic Biol Med 22: 871-883, 1997.
201. Martinet W, Schrijvers DM, Timmermans JP, and Bult H. Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells. Br J Pharmacol 154: 1236-1246, 2008.
202. Mason PJ, Stevens D, Diez A, Knight SW, Scopes DA, and Vulliamy TJ. Human hexose-6-phosphate dehydroge-nase (glucose 1-dehydrogenase) encoded at 1p36: Coding sequence and expression. Blood Cells Mol Dis 25: 30-37, 1999.
203. Matsumoto A, Okado A, Fujii T, Fujii J, Egashira M, Nii-kawa N, and Taniguchi N. Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member. FEBS Lett 443: 246-250, 1999.
204. Matus S, Lisbona F, Torres M, Leon C, Thielen P, and Hetz C. The stress rheostat: An interplay between the unfolded protein response (UPR) and autophagy in neurodegenera-tion. Curr Mol Med 8: 157-172, 2008.
205. McCullough KD, Martindale JL, Klotz LO, Aw TY, and Holbrook NJ. Gadd153 sensitizes cells to endoplasmic re-ticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259, 2001.
206. Meissner G. NADH, a new player in the cardiac ryanodine receptor? Circ Res 94: 418-419, 2004. (Pubitemid 38326276)
207. Merksamer PI, Trusina A, and Papa FR. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell 135: 933-947, 2008.
208. Mhaille AN, McQuaid S, Windebank A, Cunnea P, McMahon J, Samali A, and FitzGerald U. Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions. J Neuro-pathol Exp Neurol 67: 200-211, 2008.
209. Michalak M, Groenendyk J, Szabo E, Gold LI, and Opas M. Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 417: 651-666, 2009.
210. 2\+ channel and its cellular function. Biochem Soc Symp 9-22, 2007.
211. 2\+ channel: From discovery to new signaling concepts. J Neurochem 102: 1426-1446, 2007.
212. Miller WL. Minireview: Regulation of steroidogenesis by electron transfer. Endocrinology 146: 2544-2550, 2005.
213. Mintz M, Vanderver A, Brown KJ, Lin J, Wang Z, Kaneski C, Schiffmann R, Nagaraju K, Hoffman EP, and Hathout Y. Time series proteome profiling to study endoplasmic re-ticulum stress response. J Proteome Res 7: 2435-2444, 2008.
214. Mizutani A, Sanuki R, Kakimoto K, Kojo S, and Taketani S. Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions. J Biochem 142: 699-705, 2007.
215. Molinari M and Sitia R. The secretory capacity of a cell depends on the efficiency of endoplasmic reticulum-associated degradation. Curr Top Microbiol Immunol 300: 1-15, 2005.
216. Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, and Sitia R. Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum. J Biol Chem 279: 32667-32673, 2004.
217. Momoi T. Caspases involved in ER stress-mediated cell death. J Chem Neuroanat 28: 101-105, 2004.
218. Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, and Farese RV Jr. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 6: 69-78, 2007.
219. Morishima N, Nakanishi K, Takenouchi H, Shibata T, and Yasuhiko Y. An endoplasmic reticulum stress-specific cas-pase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277: 34287-34294, 2002.
220. Morton NM and Seckl JR. 11b-Hydroxysteroid dehydroge-nase type 1 and obesity. Front Horm Res 36: 146-164, 2008.
221. Mouw G, Zechel JL, Gamboa J, Lust WD, Selman WR, and Ratcheson RA. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. Neuroreport 14: 183-186, 2003.
222. Nadanaka S, Okada T, Yoshida H, and Mori K. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol Cell Biol 27: 1027-1043, 2007.
223. Nadanaka S, Yoshida H, and Mori K. Reduction of dis-ulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. Cell Struct Funct 31: 127-134, 2006.
224. Nagy G, Kardon T, Wunderlich L, Szarka A, Kiss A, Schaff Z, Banhegyi G, and Mandl J. Acetaminophen induces ER dependent signaling in mouse liver. Arch Biochem Biophys 459: 273-279, 2007.
225. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, and Yuan J. Caspase-12 mediates endoplasmic reticulum-specific apoptosis and cytotoxicity by amyloid-b. Nature 403: 98-103, 2000.
226. Nakamura T and Lipton SA. Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxid Redox Signal 10: 87-101, 2008.
227. Nardai G, Braun L, Csala M, Mile V, Csermely P, Benedetti A, Mandl J, and Banhegyi G. Protein-disulfide isomerase-and protein thiol-dependent dehydroascorbate reduction and ascorbate accumulation in the lumen of the endoplas-mic reticulum. J Biol Chem 276: 8825-8828, 2001.
228. Ni M and Lee AS. ER chaperones in mammalian development and human diseases. FEBS Lett 581: 3641-3651, 2007.
229. Nishikimi M, Noguchi E, and Yagi K. Occurrence in yeast of L-galactonolactone oxidase which is similar to a key enzyme for ascorbic acid biosynthesis in animals, L-gulonolactone oxidase. Arch Biochem Biophys 191: 479-486, 1978.
230. Nishikimi M and Yagi K. Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Am J Clin Nutr 54: 1203S-1208S, 1991.
231. Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, and Ichijo H. ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev 22: 1451-1464, 2008.
232. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuro-nal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355, 2002.
233. Nowak TS, Jr., Fried RL, Lust WD, and Passonneau JV. Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil. J Neu-rochem 44: 487-494, 1985.
234. Odermatt A, Atanasov AG, Balazs Z, Schweizer RA, Nashev LG, Schuster D, and Langer T. Why is 11b-hydroxysteroid dehydrogenase type 1 facing the endo-plasmic reticulum lumen? Physiological relevance of the membrane topology of 11b-HSD1. Mol Cell Endocrinol 248: 15-23, 2006.
235. Ohsaki Y, Cheng J, Suzuki M, Fujita A, and Fujimoto T. Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100. J Cell Sci 121: 2415-2422, 2008.
236. Ohsaki Y, Cheng J, Suzuki M, Shinohara Y, Fujita A, and Fujimoto T. Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structure. Biochim Biophys Acta 1791: 399-407, 2009.
237. Oida Y, Izuta H, Oyagi A, Shimazawa M, Kudo T, Im-aizumi K, and Hara H. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res 1208: 217-224, 2008.
238. Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, and Sitia R. Dynamic retention of Ero1a and Ero1b in the endoplasmic reticulum by interactions with PDI and ERp44. Antioxid Redox Signal 8: 274-282, 2006.
239. Oyadomari S and Mori M. Roles of CHOP=GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389, 2004.
240. Oyadomari S, Harding HP, Zhang Y, Oyadomari M, and Ron D. Dephosphorylation of translation initiation factor 2a enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7: 520-532, 2008.
241. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, and Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461, 2004.
242. Ozols J. Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate de-hydrogenase. Proc Natl Acad Sci USA 90: 5302-5306, 1993.
243. Ozols J. Lumenal orientation and post-translational modifications of the liver microsomal 11b-hydroxysteroid de-hydrogenase. J Biol Chem 270: 10360, 1995.
244. 2\+ and reactive oxygen intermediates as messengers. FEBS Lett 392: 129-136, 1996.
245. Papp E, Nardai G, Soti C, and Csermely P. Molecular chaperones, stress proteins and redox homeostasis. Biofac-tors 17: 249-257, 2003.
246. Papp E, Szaraz P, Korcsmaros T, and Csermely P. Changes of endoplasmic reticulum chaperone complexes, redox state, and impaired protein disulfide reductase activity in misfolding a1-antitrypsin transgenic mice. FASEB J 20: 1018-1020, 2006.
247. Paschen W, Gissel C, Linden T, Althausen S, and Doutheil J. Activation of gadd153 expression through transient cerebral ischemia: Evidence that ischemia causes endo-plasmic reticulum dysfunction. Brain Res Mol Brain Res 60: 115-122, 1998.
248. Paschen W and Mengesdorf T. Endoplasmic reticulum stress response and neurodegeneration. Cell Calcium 38: 409-415, 2005.
249. Perry TL, Godin DV, and Hansen S. Parkinson's disease: A disorder due to nigral glutathione deficiency? Neurosci Lett 33: 305-310, 1982.
250. Petrelli MD, Lim-Tio SS, Condon J, Hewison M, and Stewart PM. Differential expression of nuclear 11b-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues. Endocrinology 138: 3077-3080, 1997.
251. Piccirella S, Czegle I, Lizak B, Margittai E, Senesi S, Papp E, Csala M, Fulceri R, Csermely P, Mandl J, Benedetti A, and Banhegyi G. Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. J Biol Chem 281: 4671-4677, 2006.
252. Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, and Cardozo AK. Transcriptional regulation of the endo-plasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes 56: 1069-1077, 2007.
253. Pollak N, Dolle C, and Ziegler M. The power to reduce: Pyridine nucleotides-small molecules with a multitude of functions. Biochem J 402: 205-218, 2007.
254. Pollard MG, Travers KJ, and Weissman JS. Ero1p: A novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell 1: 171-182, 1998.
255. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papape-tropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, and Nussbaum RL. Mutation in the a-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047, 1997.
256. Prentki M and Nolan CJ. Islet b cell failure in type 2 diabetes. J Clin Invest 116: 1802-1812, 2006.
257. Puskas F, Braun L, Csala M, Kardon T, Marcolongo P, Benedetti A, Mandl J, and Banhegyi G. Gulonolactone oxidase activity-dependent intravesicular glutathione oxidation in rat liver microsomes. FEBS Lett 430: 293-296, 1998.
258. Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, and Weissman JS. Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell 32: 870-877, 2008.
259. Radominska-Pandya A, Czernik PJ, Little JM, Battaglia E, and Mackenzie PI. Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev 31: 817-899, 1999.
260. Randle PJ. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-283, 1998.
261. Randle PJ, Garland PB, Hales CN, and Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789, 1963.
262. Rao RV and Bredesen DE. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 16: 653-662, 2004.
263. Revesz K, Tutto A, Margittai E, Banhegyi G, Magyar JE, Mandl J, and Csala M. Glucuronide transport across the endoplasmic reticulum membrane is inhibited by epi-gallocatechin gallate and other green tea polyphenols. Int J Biochem Cell Biol 39: 922-930, 2007.
264. Rhee SG, Chae HZ, and Kim K. Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med 38: 1543-1552, 2005.
265. Roberts GG, Di Loreto MJ, Marshall M, Wang J, and De-Gracia DJ. Hippocampal cellular stress responses after global brain ischemia and reperfusion. Antioxid Redox Signal 9: 2265-2275, 2007.
266. Robertson RP, Harmon J, Tran PO, and Poitout V. b-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 Suppl 1: S119-124, 2004.
267. Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, and Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 64: 5943-5947, 2004.
268. Ron D and Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C=EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453, 1992.
269. Ron D and Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529, 2007.
270. Ruddock LW and Molinari M. N-glycan processing in ER quality control. J Cell Sci 119: 4373-4380, 2006.
271. Ruiz-Vela A, Opferman JT, Cheng EH, and Korsmeyer SJ. Proapoptotic BAX and BAK control multiple initiator cas-pases. EMBO Rep 6: 379-385, 2005.
272. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, and Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 22: 10690-10698, 2002.
273. Saaranen MJ, Karala AR, Lappi AK, and Ruddock LW. The role of dehydroascorbate in disulfide bond formation. Antioxid Redox Signal 12: 15-25, 2010.
274. Scheuner D and Kaufman RJ. The unfolded protein response: A pathway that links insulin demand with b-cell failure and diabetes. Endocr Rev 29: 317-333, 2008.
275. Schrag JD, Procopio DO, Cygler M, Thomas DY, and Bergeron JJ. Lectin control of protein folding and sorting in the secretory pathway. Trends Biochem Sci 28: 49-57, 2003.
276. Schroder M. Endoplasmic reticulum stress responses. Cell Mol Life Sci 65: 862-894, 2008.
277. Schroder M and Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 569: 29-63, 2005.
278. Schwarzlander M, Fricker MD, Muller C, Marty L, Brach T, Novak J, Sweetlove LJ, Hell R, and Meyer AJ. Confocal imaging of glutathione redox potential in living plant cells. J Microsc 231: 299-316, 2008.
279. Schweizer RA, Zurcher M, Balazs Z, Dick B, and Odermatt A. Rapid hepatic metabolism of 7-ketocholesterol by 11b-hydroxysteroid dehydrogenase type 1: Species-specific differences between the rat, human, and hamster enzyme. J Biol Chem 279: 18415-18424, 2004.
280. Sciandra JJ, Subjeck JR, and Hughes CS. Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation. Proc Natl Acad Sci USA 81: 4843-4847, 1984.
281. Seckl JR. 11b-hydroxysteroid dehydrogenases: Changing glucocorticoid action. Curr Opin Pharmacol 4: 597-602, 2004.
282. Seckl JR and Walker BR. 11b-hydroxysteroid dehydroge-nase type 1 as a modulator of glucocorticoid action: From metabolism to memory. Trends Endocrinol Metab 15: 418-424, 2004.
283. Sekar N, Qian S, and Shechter Y. Vanadate elevates lipo-genicity of starved rat adipose tissue: Mechanism of action. Endocrinology 139: 2514-2518, 1998.
284. Semenza GL. HIF-1: Mediator of physiological and patho-physiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
285. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
286. Senesi S, Marcolongo P, Manini I, Fulceri R, Sorrentino V, Csala M, Banhegyi G, and Benedetti A. Constant expression of hexose-6-phosphate dehydrogenase during differentiation of human adipose-derived mesenchymal stem cells. J Mol Endocrinol 41: 125-133, 2008.
287. Sevier CS, Qu H, Heldman N, Gross E, Fass D, and Kaiser CA. Modulation of cellular disulfide-bond formation and the ER redox environment by feedback regulation of Ero1. Cell 129: 333-344, 2007.
288. Sharma MK and Buettner GR. Interaction of vitamin C and vitamin E during free radical stress in plasma: An ESR study. Free Radic Biol Med 14: 649-653, 1993.
289. Sharma NK, Das SK, Mondal AK, Hackney OG, Chu WS, Kern PA, Rasouli N, Spencer HJ, Yao-Borengasser A, and Elbein SC. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin En-docrinol Metab 93: 4532-4541, 2008.
290. Shastry BS. Neurodegenerative disorders of protein aggregation. Neurochem Int 43: 1-7, 2003.
291. Shen J, Snapp EL, Lippincott-Schwartz J, and Prywes R. Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol Cell Biol 25: 921-932, 2005.
292. Shintani-Ishida K, Nakajima M, Uemura K, and Yoshida K. Ischemic preconditioning protects cardiomyocytes against ischemic injury by inducing GRP78. Biochem Biophys Res Commun 345: 1600-1605, 2006.
293. Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, and Yamamoto M. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcino-genesis. J Hepatol 38: 605-614, 2003.
294. Sitia R and Molteni SN. Stress, protein (mis)folding, and signaling: The redox connection. Sci STKE 2004: pe27, 2004.
295. Suzuki H, Kanekura K, Levine TP, Kohno K, Olkkonen VM, Aiso S, and Matsuoka M. ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB. J Neurochem 108: 973-985, 2009.
296. Szarka A, Stadler K, Jenei V, Margittai E, Csala M, Jakus J, Mandl J, and Banhegyi G. Ascorbyl free radical and dehy-droascorbate formation in rat liver endoplasmic reticulum. J Bioenerg Biomembr 34: 317-323, 2002.
297. Szegezdi E, Logue SE, Gorman AM, and Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885, 2006.
298. Tajiri S, Oyadomari S, Yano S, Morioka M, Gotoh T, Ha-mada JI, Ushio Y, and Mori M. Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death Differ 11: 403-415, 2004.
299. Takahashi T and Hori SH. Intramembraneous localization of rat liver microsomal hexose-6-phosphate dehydrogenase and membrane permeability to its substrates. Biochim Bio-phys Acta 524: 262-276, 1978.
300. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O, Nishimura H, Yamashita A, Okabe M, Yanagi H, Stern DM, Ogawa S, and Tohyama M. ORP150 protects against hypoxia=ischemia-induced neuronal death. Nat Med 7: 317-323, 2001.
301. Tan Y, Dourdin N, Wu C, De Veyra T, Elce JS, and Greer PA. Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced ap-optosis. J Biol Chem 281: 16016-16024, 2006.
302. Tanaka S, Uehara T, and Nomura Y. Up-regulation of protein-disulfide isomerase in response to hypoxia=brain ischemia and its protective effect against apoptotic cell death. J Biol Chem 275: 10388-10393, 2000.
303. Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, and Hugon J. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress. J Neurosci Res 69: 530-539, 2002.
304. Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, and Glembotski CC. Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res 99: 275-282, 2006.
305. Tobisawa S, Hozumi Y, Arawaka S, Koyama S, Wada M, Nagai M, Aoki M, Itoyama Y, Goto K, and Kato T. Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice. Biochem Biophys Res Commun 303: 496-503, 2003.
306. Todd DJ, Lee AH, and Glimcher LH. The endoplasmic re-ticulum stress response in immunity and autoimmunity. Nat Rev Immunol 8: 663-674, 2008.
307. Tomlinson JW. 11b-Hydroxysteroid dehydrogenase type 1 in human disease: A novel therapeutic target. Minerva En-docrinol 30: 37-46, 2005.
308. Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, and Stewart PM. 11b-Hydroxysteroid dehydrogenase type 1: A tissue-specific regulator of glucocorticoid response. Endocr Rev 25: 831-866, 2004.
309. Tu BP, Ho-Schleyer SC, Travers KJ, and Weissman JS. Biochemical basis of oxidative protein folding in the en-doplasmic reticulum. Science 290: 1571-1574, 2000.
310. 2-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol Cell 10: 983-994, 2002.
311. Tu BP and Weissman JS. Oxidative protein folding in eu-karyotes: Mechanisms and consequences. J Cell Biol 164: 341-346, 2004.
312. Uehara T. Accumulation of misfolded protein through ni-trosative stress linked to neurodegenerative disorders. Antioxid Redox Signal 9: 597-601, 2007.
313. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, and Lipton SA. S-nitrosylated protein-disulfide isomerase links protein misfolding to neurodegeneration. Nature 441: 513-517, 2006.
314. Unterberger U, Höftberger R, Gelpi E, Flicker H, Budka H, and Voigtländer T. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J Neuropathol Exp Neurol 65: 348-357, 2006.
315. Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, and Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666, 2000.
316. Ushioda R, Hoseki J, Araki K, Jansen G, Thomas DY, and Nagata K. ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. Science 321: 569-572, 2008.
317. van Reyk DM, Brown AJ, Hult'en LM, Dean RT, and Jessup W. Oxysterols in biological systems: Sources, metabolism and pathophysiological relevance. Redox Rep 11: 255-262, 2006.
318. van Schaftingen E and Gerin I. The glucose-6-phosphatase system. Biochem J 362: 513-532, 2002.
319. Varsanyi M, Szarka A, Papp E, Makai D, Nardai G, Fulceri R, Csermely P, Mandl J, Benedetti A, and Banhegyi G. FAD transport and FAD-dependent protein thiol oxidation in rat liver microsomes. J Biol Chem 279: 3370-3374, 2004.
320. Veiga-da-Cunha M, Gerin I, Chen YT, de Barsy T, de Lonlay P, Dionisi-Vici C, Fenske CD, Lee PJ, Leonard JV, Maire I, McConkie-Rosell A, Schweitzer S, Vikkula M, and Van Schaftingen E. A gene on chromosome 11q23 coding for a putative glucose-6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic. Am J Hum Genet 63: 976-983, 1998.
321. Vembar SS and Brodsky JL. One step at a time: En-doplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol 9: 944-957, 2008.
322. Verkhratsky A. Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev 85: 201-279, 2005.
323. Wahlman J, DeMartino GN, Skach WR, Bulleid NJ, Brodsky JL, and Johnson AE. Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system. Cell 129: 943-955, 2007.
324. Wajih N, Hutson SM, and Wallin R. Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomer-ase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. J Biol Chem 282: 2626-2635, 2007.
325. Wallin R and Martin LF. Warfarin poisoning and vitamin K antagonism in rat and human liver. Design of a system in vitro that mimics the situation in vivo. Biochem J 241: 389-396, 1987.
326. Wang Y, Lam KS, Yau MH, and Xu A. Post-translational modifications of adiponectin: Mechanisms and functional implications. Biochem J 409: 623-633, 2008.
327. Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, and Scherer PE. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 27: 3716-3731, 2007.
328. Wells WW, Xu DP, Yang YF, and Rocque PA. Mammalian thioltransferase (glutaredoxin) and protein disulfide isom-erase have dehydroascorbate reductase activity. J Biol Chem 265: 15361-15364, 1990.
329. Werner R, Manthey KC, Griffin JB, and Zempleni J. HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem 16: 617-624, 2005.
330. White PC, Rogoff D, McMillan DR, and Lavery GG. Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism. Mol Cell Endocrinol 265-266: 89-92, 2007.
331. Williams DB. Beyond lectins: The calnexin=calreticulin chaperone system of the endoplasmic reticulum. J Cell Sci 119: 615-623, 2006.
332. Wolf G. New insights into thiol-mediated regulation of adiponectin secretion. Nutr Rev 66: 642-645, 2008.
333. Wonderlin WF. Constitutive, translation-independent opening of the protein-conducting channel in the endo-plasmic reticulum. Pflugers Arch 457: 917-930, 2009.
334. Wootz H, Hansson I, Korhonen L, Napankangas U, and Lindholm D. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem Biophys Res Commun 322: 281-286, 2004.
335. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, and Li P. Cideb, an ER-and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab 9: 177-190, 2009.
336. Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, and Tohyama M. Activation of caspase-12, an en-doplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem 276: 13935-13940, 2001.
337. Yoshida H. ER stress and diseases. FEBS J 274: 630-658, 2007.
338. 2\+ release mechanism. J Biol Chem 272:
339. Zhang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, and Kitajima S. Activation of JNK and transcrip-tional repressor ATF3=LRF1 through the IRE1=TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun 289: 718-724, 2001.
340. Zhang K and Kaufman RJ. From endoplasmic reticulum stress to the inflammatory response. Nature 454: 455-462, 2008.
341. Zhu H, Larade K, Jackson TA, Xie J, Ladoux A, Acker H, Berchner-Pfannschmidt U, Fandrey J, Cross AR, Lukat-Rodgers GS, Rodgers KR, and Bunn HF. NCB5OR is a novel soluble NAD(P)H reductase localized in the endo-plasmic reticulum. J Biol Chem 279: 30316-30325, 2004.
342. Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, and Thompson CB. Bax and Bak can localize to the en-doplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69, 2003.