The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis

Experimental Gerontology

Volumn 41, Issue 4, 2006, Pages 380-386

  Hoozemans, Jeroen J M ^a   Stieler, Jens ^c   van Haastert, Elise S ^a   Veerhuis, Robert ^b   Rozemuller, Annemieke J M ^a   Baas, Frank ^a   Eikelenboom, Piet ^a   Arendt, Thomas ^c   Scheper, Wiep ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alzheimer's disease; Cell cycle; Endoplasmic reticulum stress; Neuron; Unfolded protein response

Indexed keywords

AMYLOID; CYCLIN D1; CYCLIN E; GLUCOSE REGULATED PROTEIN 78; PROTEIN P27; RETINOBLASTOMA PROTEIN; THAPSIGARGIN; TUNICAMYCIN;

ALZHEIMER DISEASE; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE CELL; NERVE DEGENERATION; NEUROBLASTOMA CELL; NEUROPATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; STRESS;

ALZHEIMER DISEASE; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CYCLIN D; CYCLIN E; CYCLINS; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR CHAPERONES; NEUROBLASTOMA; NEURONS; PHOSPHORYLATION; PROTEIN FOLDING; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 33646188838     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.01.013     Document Type: Article

References (27)

1. Arendt T. Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization. Neuroscience 102 (2001) 723-765
2. Arendt T., Rodel L., Gartner U., and Holzer M. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport 7 (1996) 3047-3049
3. Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 82 (1991) 239-259
4. Brewer J.W., and Diehl J.A. PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc. Natl Acad. Sci. USA 97 (2000) 12625-12630
5. Brewer J.W., Hendershot L.M., Sherr C.J., and Diehl J.A. Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc. Natl Acad. Sci. USA 96 (1999) 8505-8510
6. Busser J., Geldmacher D.S., and Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J. Neurosci. 18 (1998) 2801-2807
7. Copani A., Condorelli F., Caruso A., Vancheri C., Sala A., Giuffrida Stella A.M., Canonico P.L., Nicoletti F., and Sortino M.A. Mitotic signaling by beta-amyloid causes neuronal death. FASEB J. 13 (1999) 2225-2234
8. Forman M.S., Lee V.M., and Trojanowski J.Q. 'Unfolding' pathways in neurodegenerative disease. Trends Neurosci. 26 (2003) 407-410
9. Gartner U., Holzer M., and Arendt T. Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration. Neuroscience 91 (1999) 1-5
10. Gouras G.K., Almeida C.G., and Takahashi R.H. Intraneuronal abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol. Aging 26 (2005) 1235-1244
11. Hoozemans J.J., Bruckner M.K., Rozemuller A.J., Veerhuis R., Eikelenboom P., and Arendt T. Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J. Neuropathol. Exp. Neurol. 61 (2002) 678-688
12. Hoozemans J.J., Veerhuis R., Rozemuller A.J., Arendt T., and Eikelenboom P. Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. Neurobiol. Dis. 15 (2004) 492-499
13. Hoozemans J.J., Veerhuis R., Van Haastert E.S., Rozemuller J.M., Baas F., Eikelenboom P., and Scheper W. The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol. (Berl.) 110 (2005) 165-172
14. Hoozemans, J.J., Veerhuis, R., Rozemuller, J.M., Eikelenboom, P., 2006. Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology. Int. J. Dev. Neurosci. 24, 157-165.
15. Klyubin I., Walsh D.M., Lemere C.A., Cullen W.K., Shankar G.M., Betts V., Spooner E.T., Jiang L., Anwyl R., Selkoe D.J., and Rowan M.J. Amyloid beta protein immunotherapy neutralizes abeta oligomers that disrupt synaptic plasticity in vivo. Nat. Med. 11 (2005) 556-561
16. Kozutsumi Y., Segal M., Normington K., Gething M.J., and Sambrook J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332 (1988) 462-464
17. Kranenburg O., van der Eb A.J., and Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15 (1996) 46-54
18. Liu D.X., and Greene L.A. Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res. 305 (2001) 217-228
19. Nagy Z., Esiri M.M., Cato A.M., and Smith A.D. Cell cycle markers in the hippocampus in Alzheimer's disease. Acta Neuropathol. (Berl.) 94 (1997) 6-15
20. Ogawa O., Lee H.G., Zhu X., Raina A., Harris P.L., Castellani R.J., Perry G., and Smith M.A. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell 2 (2003) 105-110
21. Rutkowski D.T., and Kaufman R.J. A trip to the ER: coping with stress. Trends Cell Biol. 14 (2004) 20-28
22. Suen K.C., Lin K.F., Elyaman W., So K.F., Chang R.C., and Hugon J. Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity. J. Neurochem. 87 (2003) 1413-1426
23. Taylor J.P., Hardy J., and Fischbeck K.H. Toxic proteins in neurodegenerative disease. Science 296 (2002) 1991-1995
24. Ueberham U., and Arendt T. The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease. Curr. Drug. Targets CNS Neurol. Disord. 4 (2005) 293-306
25. Vincent I., Jicha G., Rosado M., and Dickson D.W. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci. 17 (1997) 3588-3598
26. Yang Y., Mufson E.J., and Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci. 23 (2003) 2557-2563
27. Yu Z., Luo H., Fu W., and Mattson M.P. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp. Neurol. 155 (1999) 302-314