-
1
-
-
0035370949
-
Intracellular signaling from the endoplasmic reticulum to the nucleus: The unfolded protein response in yeast and mammals
-
Patil, C. & Walter, P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 13, 349-355 (2001).
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 349-355
-
-
Patil, C.1
Walter, P.2
-
2
-
-
0030297537
-
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
-
Cox, J. S. & Walter, P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87, 391-404 (1996).
-
(1996)
Cell
, vol.87
, pp. 391-404
-
-
Cox, J.S.1
Walter, P.2
-
3
-
-
0034724520
-
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
-
Travers, K. J. et al. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101, 249-258 (2000).
-
(2000)
Cell
, vol.101
, pp. 249-258
-
-
Travers, K.J.1
-
4
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding, H. P., Zhang, Y. & Ron, D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397, 271-274 (1999).
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
5
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control
-
Shi, Y. et al. Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control. Mol. Biol. Cell 18, 7499-7509 (1998).
-
(1998)
Mol. Biol. Cell
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
-
6
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze, K., Yoshida, H., Yanagi, H., Yura, T. & Mori, K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 10, 3787-3799 (1999).
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
7
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891 (2001).
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
8
-
-
0037083755
-
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
-
Lee, K. et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16, 452-466 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 452-466
-
-
Lee, K.1
-
9
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92-96 (2002).
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
-
10
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P. & Ron, D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nature Cell Biol. 2, 326-332 (2000).
-
(2000)
Nature Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
11
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen, J., Chen, X., Hendershot, L. & Prywes, R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3, 99-111 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.3
Prywes, R.4
-
12
-
-
0038308388
-
Genetic evidence for a role of BiP/ Kar2 that regulates Ire1 in response to accumulation of unfolded proteins
-
Kimata, Y. et al. Genetic evidence for a role of BiP/ Kar2 that regulates Ire1 in response to accumulation of unfolded proteins. Mol. Biol. Cell 14, 2559-2569 (2003).
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 2559-2569
-
-
Kimata, Y.1
-
13
-
-
30044432596
-
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
-
Credle, J. J., Finer-Moore, J. S., Papa, F. R., Stroud, R. M. & Walter, P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc. Natl Acad. Sci. USA 102, 18773-18784 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18773-18784
-
-
Credle, J.J.1
Finer-Moore, J.S.2
Papa, F.R.3
Stroud, R.M.4
Walter, P.5
-
14
-
-
35348967427
-
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
-
Kimata, Y. et al. Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins. J. Cell Biol. 179, 75-86 (2007).
-
(2007)
J. Cell Biol
, vol.179
, pp. 75-86
-
-
Kimata, Y.1
-
15
-
-
0032190546
-
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
-
Wang, X. Z. et al. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17, 5708-5717 (1998).
-
(1998)
EMBO J
, vol.17
, pp. 5708-5717
-
-
Wang, X.Z.1
-
16
-
-
0035094262
-
Increased sensitivity to dextran sodium sulfate colitis in IRE1 β-deficient mice
-
Bertolotti, A. et al. Increased sensitivity to dextran sodium sulfate colitis in IRE1 β-deficient mice. J. Clin. Invest. 107, 585-593 (2001).
-
(2001)
J. Clin. Invest
, vol.107
, pp. 585-593
-
-
Bertolotti, A.1
-
17
-
-
0034312290
-
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
-
Tirasophon, W., Lee, K., Callaghan, B., Welihinda, A. & Kaufman, R. J. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev. 14, 2725-2736 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 2725-2736
-
-
Tirasophon, W.1
Lee, K.2
Callaghan, B.3
Welihinda, A.4
Kaufman, R.J.5
-
18
-
-
0029903049
-
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
-
Shamu, C. E. & Walter, P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 15, 3028-3039 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 3028-3039
-
-
Shamu, C.E.1
Walter, P.2
-
19
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase
-
Urano, F. & Wang, X. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase. Science 287, 664-666 (2000).
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
-
20
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh, H. et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16, 1345-1355 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
-
21
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
Ogata, M. et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 26, 9220-9231 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
-
22
-
-
34548188741
-
Self-eating and self-killing: Crosstalk between autophagy and apoptosis
-
Maiuri, M. C., Zalckvar, E., Kimchi, A. & Kroemer, G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nature Rev. Mol. Cell Biol. 8, 741-752 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol
, vol.8
, pp. 741-752
-
-
Maiuri, M.C.1
Zalckvar, E.2
Kimchi, A.3
Kroemer, G.4
-
23
-
-
0035957929
-
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
-
Yoneda, T. et al. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 276, 13935-13940 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 13935-13940
-
-
Yoneda, T.1
-
24
-
-
0043193876
-
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
-
Lee, A. H., Iwakoshi, N. N., Anderson, K. C. & Glimcher, L. H. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc. Natl Acad. Sci. USA 100, 9946-9951 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 9946-9951
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Anderson, K.C.3
Glimcher, L.H.4
-
25
-
-
33646824929
-
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response
-
Tirosh, B., Iwakoshi, N. N., Glimcher, L. H. & Ploegh, H. L. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J. Biol. Chem. 281, 5852-5860 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 5852-5860
-
-
Tirosh, B.1
Iwakoshi, N.N.2
Glimcher, L.H.3
Ploegh, H.L.4
-
26
-
-
32644432826
-
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
-
Yoshida, H., Oku, M., Suzuki, M. & Mori, K. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J. Cell Biol. 172, 565-575 (2006).
-
(2006)
J. Cell Biol
, vol.172
, pp. 565-575
-
-
Yoshida, H.1
Oku, M.2
Suzuki, M.3
Mori, K.4
-
27
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
Lee, A. H., Iwakoshi, N. N. & Glimcher, L. H. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell. Biol. 23, 7448-7459 (2003).
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
28
-
-
0025320560
-
A new member of the leucine zipper class of proteins that binds to the HLA DR α promoter
-
Liou, H. C. et al. A new member of the leucine zipper class of proteins that binds to the HLA DR α promoter. Science 247, 1581-1584 (1990).
-
(1990)
Science
, vol.247
, pp. 1581-1584
-
-
Liou, H.C.1
-
29
-
-
0029889755
-
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core
-
Clauss, I. M., Chu, M., Zhao, J. L. & Glimcher, L. H. The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core. Nucleic Acids Res. 24, 1855-1864 (1996).
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 1855-1864
-
-
Clauss, I.M.1
Chu, M.2
Zhao, J.L.3
Glimcher, L.H.4
-
30
-
-
0027170850
-
In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis
-
Clauss, I. M. et al. In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev. Dyn. 197, 146-156 (1993).
-
(1993)
Dev. Dyn
, vol.197
, pp. 146-156
-
-
Clauss, I.M.1
-
31
-
-
0034650851
-
An essential role in liver development for transcription factor XBP-1
-
Reimold, A. M. et al. An essential role in liver development for transcription factor XBP-1. Genes Dev. 14, 152-157 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 152-157
-
-
Reimold, A.M.1
-
32
-
-
29244448729
-
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
-
This paper shows additional roles for XBP1 and the UPR in the genesis of secretory structures such as exocrine gland acinar cells
-
Lee, A. H., Chu, G. C., Iwakoshi, N. N. & Glimcher, L. H. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J. 24, 4368-4380 (2005). This paper shows additional roles for XBP1 and the UPR in the genesis of secretory structures such as exocrine gland acinar cells.
-
(2005)
EMBO J
, vol.24
, pp. 4368-4380
-
-
Lee, A.H.1
Chu, G.C.2
Iwakoshi, N.N.3
Glimcher, L.H.4
-
33
-
-
33646237823
-
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α
-
Hetz, C. et al. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α. Science 312, 572-576 (2006).
-
(2006)
Science
, vol.312
, pp. 572-576
-
-
Hetz, C.1
-
34
-
-
9644303176
-
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress
-
Gu, F. et al. Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J. Biol. Chem. 279, 49689-49693 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 49689-49693
-
-
Gu, F.1
-
35
-
-
37849026130
-
The daily job of night killers: Alternative roles of the BCL-2 family in organelle physiology
-
Hetz, C. & Glimcher, L. The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology. Trends Cell Biol. 18, 38-44 (2008).
-
(2008)
Trends Cell Biol
, vol.18
, pp. 38-44
-
-
Hetz, C.1
Glimcher, L.2
-
36
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding, H. P. et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6, 1099-1108 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
-
37
-
-
5444264022
-
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
-
Lu, P. D., Harding, H. P. & Ron, D. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J. Cell Biol. 167, 27-33 (2004).
-
(2004)
J. Cell Biol
, vol.167
, pp. 27-33
-
-
Lu, P.D.1
Harding, H.P.2
Ron, D.3
-
38
-
-
3843117589
-
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
-
Vattem, K. M. & Wek, R. C. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc. Natl Acad. Sci. USA 101, 11269-11274 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11269-11274
-
-
Vattem, K.M.1
Wek, R.C.2
-
39
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
-
Novoa, I., Zeng, H., Harding, H. P. & Ron, D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α. J. Cell Biol. 153, 1011-1022 (2001).
-
(2001)
J. Cell Biol
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
40
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak, S. J. et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18, 3066-3077 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
-
41
-
-
0037066741
-
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
-
Chen, X., Shen, J. & Prywes, R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 277, 13045-13052 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 13045-13052
-
-
Chen, X.1
Shen, J.2
Prywes, R.3
-
42
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
Ye, J. et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6, 1355-1364 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
-
43
-
-
35848940511
-
Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response
-
Bailey, D. & O'Hare, P. Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response. Antioxid. Redox Signal. 9, 2305-2321 (2007).
-
(2007)
Antioxid. Redox Signal
, vol.9
, pp. 2305-2321
-
-
Bailey, D.1
O'Hare, P.2
-
44
-
-
0030941803
-
The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown, M. S. & Goldstein, J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340 (1997).
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
45
-
-
0035310752
-
Identification of the G13 (cAMP-response-element- binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
-
Haze, K. et al. Identification of the G13 (cAMP-response-element- binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem. J. 355, 19-28 (2001).
-
(2001)
Biochem. J
, vol.355
, pp. 19-28
-
-
Haze, K.1
-
46
-
-
2442647920
-
Opposing roles for ATF6α and ATF6β in endoplasmic reticulum stress response gene induction
-
Thuerauf, D. J., Morrison, L. & Glembotski, C. C. Opposing roles for ATF6α and ATF6β in endoplasmic reticulum stress response gene induction. J. Biol. Chem. 279, 21078-21084 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 21078-21084
-
-
Thuerauf, D.J.1
Morrison, L.2
Glembotski, C.C.3
-
47
-
-
44449101173
-
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum
-
Adachi, Y. et al. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct. Funct. 33, 75-89 (2008).
-
(2008)
Cell Struct. Funct
, vol.33
, pp. 75-89
-
-
Adachi, Y.1
-
48
-
-
34548172495
-
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1
-
Yamamoto, K. et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1. Dev. Cell 13, 365-376 (2007).
-
(2007)
Dev. Cell
, vol.13
, pp. 365-376
-
-
Yamamoto, K.1
-
49
-
-
34548189283
-
ATF6α optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
-
Wu, J. et al. ATF6α optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev. Cell 13, 351-364 (2007).
-
(2007)
Dev. Cell
, vol.13
, pp. 351-364
-
-
Wu, J.1
-
50
-
-
0034282912
-
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
-
Wang, Y. et al. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J. Biol. Chem. 275, 27013-27020 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 27013-27020
-
-
Wang, Y.1
-
51
-
-
0032509216
-
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
-
Yoshida, H., Haze, K., Yanagi, H., Yura, T. & Mori, K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273, 33741-33749 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 33741-33749
-
-
Yoshida, H.1
Haze, K.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
52
-
-
0033815971
-
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
-
Yoshida, H. et al. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 20, 6755-6767 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 6755-6767
-
-
Yoshida, H.1
-
53
-
-
0033559493
-
The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex
-
Roy, B. & Lee, A. S. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex. Nucleic Acids Res. 27, 1437-1443 (1999).
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 1437-1443
-
-
Roy, B.1
Lee, A.S.2
-
54
-
-
0346331895
-
Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response
-
Gass, J. N., Gunn, K. E., Sriburi, R. & Brewer, J. W. Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response. Trends Immunol. 25, 17-24 (2004).
-
(2004)
Trends Immunol
, vol.25
, pp. 17-24
-
-
Gass, J.N.1
Gunn, K.E.2
Sriburi, R.3
Brewer, J.W.4
-
55
-
-
3142658576
-
-
Shaffer, A. L. et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21, 81-93 (2004). This paper shows that the transcription factor BLIMP1 is upstream of XBP1 in plasma cells and is an important contribution to unmasking the network of transcription factors involved in plasma-cell development.
-
Shaffer, A. L. et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21, 81-93 (2004). This paper shows that the transcription factor BLIMP1 is upstream of XBP1 in plasma cells and is an important contribution to unmasking the network of transcription factors involved in plasma-cell development.
-
-
-
-
56
-
-
38449092991
-
Identification of ERdj3 and OBF-1/BOB-1/OCA-B as direct targets of XBP-1 during plasma cell differentiation
-
Shen, Y. & Hendershot, L. M. Identification of ERdj3 and OBF-1/BOB-1/OCA-B as direct targets of XBP-1 during plasma cell differentiation. J. Immunol. 179, 2969-2978 (2007).
-
(2007)
J. Immunol
, vol.179
, pp. 2969-2978
-
-
Shen, Y.1
Hendershot, L.M.2
-
57
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee, A.-H., Scapa, E. F., Cohen, D. E. & Glimcher, L. H. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320, 1492-1496 (2008).
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.-H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
58
-
-
5444222234
-
XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
-
Sriburi, R., Jackowski, S., Mori, K. & Brewer, J. W. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 167, 35-41 (2004).
-
(2004)
J. Cell Biol
, vol.167
, pp. 35-41
-
-
Sriburi, R.1
Jackowski, S.2
Mori, K.3
Brewer, J.W.4
-
59
-
-
0037058574
-
Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK
-
Yan, W. et al. Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc. Natl Acad. Sci. USA 99, 15920-15925 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 15920-15925
-
-
Yan, W.1
-
60
-
-
0038182518
-
-
IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2α signaling. J. Biol. Chem. 278, 15558-15564 (2003).
-
IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2α signaling. J. Biol. Chem. 278, 15558-15564 (2003).
-
-
-
-
61
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner, H. et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 12, 982-995 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
-
62
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
This is the first report showing that plasma-cell growth and survival are dependent on XBP1, although the UPR-dependent mechanism had yet to be identified
-
Reimold, A. M. et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412, 300-307 (2001). This is the first report showing that plasma-cell growth and survival are dependent on XBP1, although the UPR-dependent mechanism had yet to be identified.
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
-
63
-
-
0037385313
-
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
-
Iwakoshi, N. N. et al. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nature Immunol. 4, 321-329 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 321-329
-
-
Iwakoshi, N.N.1
-
64
-
-
0030052190
-
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1
-
Reimold, A. M. et al. Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J. Exp. Med. 183, 393-401 (1996).
-
(1996)
J. Exp. Med
, vol.183
, pp. 393-401
-
-
Reimold, A.M.1
-
65
-
-
0027215522
-
RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
-
Chen, J., Lansford, R., Stewart, V., Young, F. & Alt, F. W. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc. Natl Acad. Sci. USA. 90, 4528-4532 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 4528-4532
-
-
Chen, J.1
Lansford, R.2
Stewart, V.3
Young, F.4
Alt, F.W.5
-
66
-
-
0037073712
-
Activation of an unfolded protein response during differentiation of antibody-secreting B cells
-
Gass, J. N., Gifford, N. M. & Brewer, J. W. Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J. Biol. Chem. 277, 49047-49054 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 49047-49054
-
-
Gass, J.N.1
Gifford, N.M.2
Brewer, J.W.3
-
67
-
-
23944434028
-
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
-
Tirosh, B., Iwakoshi, N. N., Glimcher, L. H. & Ploegh, H. L. XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. J. Exp. Med. 202, 505-516 (2005).
-
(2005)
J. Exp. Med
, vol.202
, pp. 505-516
-
-
Tirosh, B.1
Iwakoshi, N.N.2
Glimcher, L.H.3
Ploegh, H.L.4
-
68
-
-
28844497905
-
Rapid B cell receptor-induced unfolded protein response in nonsecretory B Cells correlates with pro- versus antiapoptotic cell fate
-
Skalet, A. H. et al. Rapid B cell receptor-induced unfolded protein response in nonsecretory B Cells correlates with pro- versus antiapoptotic cell fate. J. Biol. Chem. 280, 39762-39771 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 39762-39771
-
-
Skalet, A.H.1
-
69
-
-
0026078463
-
Biogenesis of the endoplasmic reticulum in activated B lymphocytes: Temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid
-
Rush, J. S., Sweitzer, T., Kent, C., Decker, G. L. & Waechter, C. J. Biogenesis of the endoplasmic reticulum in activated B lymphocytes: temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid. Arch. Biochem. Biophys. 284, 63-70 (1991).
-
(1991)
Arch. Biochem. Biophys
, vol.284
, pp. 63-70
-
-
Rush, J.S.1
Sweitzer, T.2
Kent, C.3
Decker, G.L.4
Waechter, C.J.5
-
70
-
-
0025291580
-
Membrane biogenesis during B cell differentiation: Most endoplasmic reticulum proteins are expressed coordinately
-
Wiest, D. L. et al. Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately. J. Cell Biol. 110, 1501-1511 (1990).
-
(1990)
J. Cell Biol
, vol.110
, pp. 1501-1511
-
-
Wiest, D.L.1
-
71
-
-
14944371187
-
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
-
Zhang, K. et al. The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 115, 268-281 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 268-281
-
-
Zhang, K.1
-
72
-
-
35548935675
-
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells
-
Gass, J. N., Jiang, H.-Y., Wek, R. C. & Brewer, J. W. The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Mol. Immunol. 45, 1035-1043 (2008).
-
(2008)
Mol. Immunol
, vol.45
, pp. 1035-1043
-
-
Gass, J.N.1
Jiang, H.-Y.2
Wek, R.C.3
Brewer, J.W.4
-
73
-
-
0036217975
-
Origins and functions of B-1 cells with notes on the role of CD5
-
Berland, R. & Wortis, H. H. Origins and functions of B-1 cells with notes on the role of CD5. Annu. Rev. Immunol. 20, 253-300 (2002).
-
(2002)
Annu. Rev. Immunol
, vol.20
, pp. 253-300
-
-
Berland, R.1
Wortis, H.H.2
-
74
-
-
34250192856
-
TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
-
Genestier, L. et al. TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J. Immunol. 178, 7779-7786 (2007).
-
(2007)
J. Immunol
, vol.178
, pp. 7779-7786
-
-
Genestier, L.1
-
75
-
-
17444429245
-
Cutting Edge: Spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated transcription factors
-
Tumang, J. R., Frances, R., Yeo, S. G. & Rothstein, T. L. Cutting Edge: spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated transcription factors. J. Immunol. 174, 3173-3177 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 3173-3177
-
-
Tumang, J.R.1
Frances, R.2
Yeo, S.G.3
Rothstein, T.L.4
-
76
-
-
0142219442
-
Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
-
Shapiro-Shelef, M. et al. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19, 607-620 (2003).
-
(2003)
Immunity
, vol.19
, pp. 607-620
-
-
Shapiro-Shelef, M.1
-
77
-
-
33745182931
-
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
-
Klein, U. et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nature Immunol. 7, 773-782 (2006).
-
(2006)
Nature Immunol
, vol.7
, pp. 773-782
-
-
Klein, U.1
-
78
-
-
0032128002
-
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor
-
Niu, H., Ye, B. H. & Dalla-Favera, R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12, 1953-1961 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 1953-1961
-
-
Niu, H.1
Ye, B.H.2
Dalla-Favera, R.3
-
79
-
-
23444459544
-
Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
-
Turner, C. A., Mack, D. H. & Davis, M. M. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77, 297-306 (1994).
-
(1994)
Cell
, vol.77
, pp. 297-306
-
-
Turner, C.A.1
Mack, D.H.2
Davis, M.M.3
-
80
-
-
0030950523
-
Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation
-
Lin, Y. & Wong, K.-K. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276, 596-599 (1997).
-
(1997)
Science
, vol.276
, pp. 596-599
-
-
Lin, Y.1
Wong, K.-K.2
-
81
-
-
18444395232
-
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
-
Shaffer, A. L. et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17, 51-62 (2002).
-
(2002)
Immunity
, vol.17
, pp. 51-62
-
-
Shaffer, A.L.1
-
82
-
-
0036272784
-
Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells
-
Lin, K.-I., Angelin-Duclos, C., Kuo, T. C. & Calame, K. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol. Cell. Biol. 22, 4771-4780 (2002).
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 4771-4780
-
-
Lin, K.-I.1
Angelin-Duclos, C.2
Kuo, T.C.3
Calame, K.4
-
83
-
-
0030273557
-
-
Rinkenberger, J. L., Wallin, J. J., Johnson, K. W. & Koshland, M. E. An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. Immunity 5, 377-386 (1996).
-
Rinkenberger, J. L., Wallin, J. J., Johnson, K. W. & Koshland, M. E. An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. Immunity 5, 377-386 (1996).
-
-
-
-
84
-
-
15444346834
-
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
-
Mittrucker, H.-W. et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 275, 540-543 (1997).
-
(1997)
Science
, vol.275
, pp. 540-543
-
-
Mittrucker, H.-W.1
-
85
-
-
33747133955
-
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
-
Sciammas, R. et al. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25, 225-236 (2006).
-
(2006)
Immunity
, vol.25
, pp. 225-236
-
-
Sciammas, R.1
-
86
-
-
34948897411
-
The transcription factor XBP-1 is essential for the development and survival of dendritic cells
-
This paper shows that XBP1 is important for DC development and survival, which has implications for the role of the UPR in early facets of the immune response
-
Iwakoshi, N. N., Pypaert, M. & Glimcher, L. H. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J. Exp. Med. 204, 2267-2275 (2007). This paper shows that XBP1 is important for DC development and survival, which has implications for the role of the UPR in early facets of the immune response.
-
(2007)
J. Exp. Med
, vol.204
, pp. 2267-2275
-
-
Iwakoshi, N.N.1
Pypaert, M.2
Glimcher, L.H.3
-
87
-
-
0035873671
-
CREB-H: A novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression
-
Omori, Y. et al. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res. 29, 2154-2162 (2001).
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2154-2162
-
-
Omori, Y.1
-
88
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang, K. et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587-599 (2006).
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
-
89
-
-
0036175125
-
Proteotoxicity in the endoplasmic reticulum: Lessons from the Akita diabetic mouse
-
Ron, D. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J. Clin. Invest. 109, 443-445 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 443-445
-
-
Ron, D.1
-
90
-
-
33846548110
-
-
Yoshida, H. ER stress and diseases. FASEB J. 274, 630-658 (2007). A review that highlights the potential role of the UPR in various diseases, including neurodegenerative diseases and type 1 diabetes.
-
Yoshida, H. ER stress and diseases. FASEB J. 274, 630-658 (2007). A review that highlights the potential role of the UPR in various diseases, including neurodegenerative diseases and type 1 diabetes.
-
-
-
-
91
-
-
0015914854
-
High association of an HL-A antigen, W27, with ankylosing spondylitis
-
Schlosstein, L., Terasaki, P. I., Bluestone, R. & Pearson, C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N. Engl. J. Med. 288, 704-706 (1973).
-
(1973)
N. Engl. J. Med
, vol.288
, pp. 704-706
-
-
Schlosstein, L.1
Terasaki, P.I.2
Bluestone, R.3
Pearson, C.M.4
-
93
-
-
0032742012
-
Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies
-
Mear, J. P. et al. Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J. Immunol. 163, 6665-6670 (1999).
-
(1999)
J. Immunol
, vol.163
, pp. 6665-6670
-
-
Mear, J.P.1
-
94
-
-
0037189545
-
HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum
-
Dangoria, N. S. et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J. Biol. Chem. 277, 23459-23468 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23459-23468
-
-
Dangoria, N.S.1
-
95
-
-
33846194065
-
HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease
-
Turner, M. J., Delay, M. L., Bai, S., Klenk, E. & Colbert, R. A. HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: implications for the pathogenesis of spondylarthritis-like disease. Arthritis Rheum. 56, 215-223 (2007).
-
(2007)
Arthritis Rheum
, vol.56
, pp. 215-223
-
-
Turner, M.J.1
Delay, M.L.2
Bai, S.3
Klenk, E.4
Colbert, R.A.5
-
97
-
-
33746897749
-
-
Smith, J. A., Marker-Hermann, E. & Colbert, R. A. Pathogenesis of ankylosing spondylitis: current concepts. Best Pract. Res. Clin. Rheumatol. 20, 571-591 (2006). This is a review on the role of the UPR in the pathogenesis of ankylosing spondylitis based on research obtained from the HLA-B27 transgenic rat model of the disease.
-
Smith, J. A., Marker-Hermann, E. & Colbert, R. A. Pathogenesis of ankylosing spondylitis: current concepts. Best Pract. Res. Clin. Rheumatol. 20, 571-591 (2006). This is a review on the role of the UPR in the pathogenesis of ankylosing spondylitis based on research obtained from the HLA-B27 transgenic rat model of the disease.
-
-
-
-
98
-
-
14644390321
-
An initial blueprint for myogenic differentiation
-
Blais, A. et al. An initial blueprint for myogenic differentiation. Genes Dev. 19, 553-569 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 553-569
-
-
Blais, A.1
-
99
-
-
34250794495
-
-
Acosta-Alvear, D. et al. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol. Cell 27, 53-66 (2007). A compelling study that uses genome-wide approaches to identify many putative XBP1 target genes, including Mist1.
-
Acosta-Alvear, D. et al. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol. Cell 27, 53-66 (2007). A compelling study that uses genome-wide approaches to identify many putative XBP1 target genes, including Mist1.
-
-
-
-
100
-
-
1442299170
-
Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract
-
Johnson, C. L., Kowalik, A. S., Rajakumar, N. & Pin, C. L. Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract. Mech. Dev. 121, 261-272 (2004).
-
(2004)
Mech. Dev
, vol.121
, pp. 261-272
-
-
Johnson, C.L.1
Kowalik, A.S.2
Rajakumar, N.3
Pin, C.L.4
-
101
-
-
1542784578
-
Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle
-
Vattemi, G., Engel, W. K., McFerrin, J. & Askanas, V. Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle. Am. J. Pathol. 164, 1-7 (2004).
-
(2004)
Am. J. Pathol
, vol.164
, pp. 1-7
-
-
Vattemi, G.1
Engel, W.K.2
McFerrin, J.3
Askanas, V.4
-
102
-
-
20744448833
-
Activation of the endoplasmic reticulum stress response in autoimmune myositis: Potential role in muscle fiber damage and dysfunction
-
Nagaraju, K. et al. Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis Rheum. 52, 1824-1835 (2005).
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1824-1835
-
-
Nagaraju, K.1
-
103
-
-
0011261078
-
Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
-
Nagaraju, K. et al. Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc. Natl Acad. Sci. USA 97, 9209-9214 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 9209-9214
-
-
Nagaraju, K.1
-
104
-
-
0035054076
-
The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis
-
Blass, S. et al. The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Arthritis Rheum. 44, 761-771 (2001).
-
(2001)
Arthritis Rheum
, vol.44
, pp. 761-771
-
-
Blass, S.1
-
105
-
-
0035253485
-
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis
-
Corrigall, V. M. et al. The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J. Immunol. 166, 1492-1498 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 1492-1498
-
-
Corrigall, V.M.1
-
106
-
-
0030775140
-
Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic t lymphocyte response and tumor immunity
-
Blachere, N. E. et al. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic t lymphocyte response and tumor immunity. J. Exp. Med. 186, 1315-1322 (1997).
-
(1997)
J. Exp. Med
, vol.186
, pp. 1315-1322
-
-
Blachere, N.E.1
-
107
-
-
0038555742
-
Association of stress proteins with autoantigens: A possible mechanism for triggering autoimmunity?
-
Purcell, A. W. et al. Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity? Clin. Exp. Immunol. 132, 193-200 (2003).
-
(2003)
Clin. Exp. Immunol
, vol.132
, pp. 193-200
-
-
Purcell, A.W.1
-
108
-
-
33846811702
-
The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
-
Lin, W. et al. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J. Clin. Invest. 117, 448-456 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 448-456
-
-
Lin, W.1
-
109
-
-
17644412023
-
Inflammation, atherosclerosis, and coronary artery disease
-
Hansson, G. K. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352, 1685-1695 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 1685-1695
-
-
Hansson, G.K.1
-
110
-
-
20444461628
-
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-α and interleukin-6: Model of NF-κB- and MAP kinase-dependent inflammation in advanced atherosclerosis
-
Li, Y. et al. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-α and interleukin-6: model of NF-κB- and MAP kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 280, 21763-21772 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 21763-21772
-
-
Li, Y.1
-
111
-
-
33750221963
-
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells
-
Gargalovic, P. S. et al. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 26, 2490-2496 (2006).
-
(2006)
Arterioscler. Thromb. Vasc. Biol
, vol.26
, pp. 2490-2496
-
-
Gargalovic, P.S.1
-
112
-
-
0035144199
-
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
-
Bays, N. W., Gardner, R. G., Seelig, L. P., Joazeiro, C. A. & Hampton, R. Y. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nature Cell Biol. 3, 24-29 (2001).
-
(2001)
Nature Cell Biol
, vol.3
, pp. 24-29
-
-
Bays, N.W.1
Gardner, R.G.2
Seelig, L.P.3
Joazeiro, C.A.4
Hampton, R.Y.5
-
113
-
-
10744222535
-
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy
-
Amano, T. et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 17, 2436-2449 (2003).
-
(2003)
Genes Dev
, vol.17
, pp. 2436-2449
-
-
Amano, T.1
-
114
-
-
25144521314
-
Rheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation disease
-
Yamasaki, S., Yagishita, N., Tsuchimochi, K., Nishioka, K. & Nakajima, T. Rheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation disease. Arthritis Res. Ther. 7, 181-186 (2005).
-
(2005)
Arthritis Res. Ther
, vol.7
, pp. 181-186
-
-
Yamasaki, S.1
Yagishita, N.2
Tsuchimochi, K.3
Nishioka, K.4
Nakajima, T.5
-
115
-
-
43049096083
-
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis
-
480-485
-
Gao, B. et al. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep. 9, 480-485 (2008).
-
(2008)
EMBO Rep
, vol.9
-
-
Gao, B.1
-
116
-
-
33645852216
-
2- microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats
-
2- microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum. 54, 1317-1327 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1317-1327
-
-
Tran, T.M.1
-
117
-
-
34047136169
-
-
Carrasco, D. R. et al. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11, 349-360 (2007). This study connects myeloma-cell survival with XBP1 function and introduces a mouse model of multiple myeloma that is based on the overexpression of XBP1s.
-
Carrasco, D. R. et al. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11, 349-360 (2007). This study connects myeloma-cell survival with XBP1 function and introduces a mouse model of multiple myeloma that is based on the overexpression of XBP1s.
-
-
-
-
118
-
-
46749088320
-
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
-
Neubert, K. et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nature Med. 14, 748-755 (2008).
-
(2008)
Nature Med
, vol.14
, pp. 748-755
-
-
Neubert, K.1
-
119
-
-
33749492425
-
Endoplasmic reticulum stress signaling in disease
-
Marciniak, S. J. & Ron, D. Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86, 1133-1149 (2006).
-
(2006)
Physiol. Rev
, vol.86
, pp. 1133-1149
-
-
Marciniak, S.J.1
Ron, D.2
-
120
-
-
35448934091
-
Multiple myeloma: Charging toward a bright future
-
Katzel, J. A., Hari, P. & Vesole, D. H. Multiple myeloma: charging toward a bright future. CA Cancer J. Clin. 57, 301-318 (2007).
-
(2007)
CA Cancer J. Clin
, vol.57
, pp. 301-318
-
-
Katzel, J.A.1
Hari, P.2
Vesole, D.H.3
-
122
-
-
33744539521
-
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
-
Obeng, E. A. et al. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107, 4907-4916 (2006).
-
(2006)
Blood
, vol.107
, pp. 4907-4916
-
-
Obeng, E.A.1
-
123
-
-
34948890040
-
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
-
Davenport, E. L. et al. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 110, 2641-2649 (2007).
-
(2007)
Blood
, vol.110
, pp. 2641-2649
-
-
Davenport, E.L.1
|