Changes in the phosphorylation of initiation factor eIF-2α, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice

Journal of Neurochemistry

Volumn 78, Issue 4, 2001, Pages 779-787

  Althausen, Sonja ^a   Mengesdorf, Thorsten ^a   Mies, Günter ^a   Oláh, Laszlo ^a   Nairn, Angus C ^b   Proud, Christopher G ^c   Paschen, Wulf ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Elongation; Endoplasmic reticulum; Initiation; P70 S6 kinase; Protein synthesis; Transient focal cerebral ischaemia

Indexed keywords

ELONGATION FACTOR 2; INITIATION FACTOR 2; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN ISCHEMIA; CALCIUM HOMEOSTASIS; CELL DAMAGE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOPLASMIC RETICULUM; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REPERFUSION; TRANSIENT ISCHEMIC ATTACK; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; LASER-DOPPLER FLOWMETRY; MICE; MIDDLE CEREBRAL ARTERY; NEURONS; PEPTIDE ELONGATION FACTOR 2; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6 KINASES; THAPSIGARGIN;

EID: 0034889904     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00462.x     Document Type: Article

References (46)

1. Cerebral protein synthesis and ischemia
2. Barbiturate promotes post-ischemic reaggregation of polyribosomes in gerbil hippocampus
3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
4. Calcium dependent regulation of protein synthesis in intact mammalian cells
5. Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischemia in the rat
6. Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis
7. The effect of ischemia and recirculation on protein synthesis in the brain
8. Global brain ischemia and reperfusion-modifications in eukaryotic initiation factors associated with inhibition of translational initiation
9. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2-alpha
10. Translation initiation: Adept at adapting
11. Regulation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: Implications for stress-induced suppression of protein synthesis
12. Recovery of neuronal protein synthesis after irreversible inhibition of the endoplasmic reticulum calcium pump
13. Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: Effect of clamping cytoplasmic calcium activity at resting levels
14. Ultrastructural localisation of phosphorylated eIF2α [eIF2αP] in rat dorsal hippocampus during reperfusion
15. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
16. A reproducible model of middle cerebral artery occlusion in mice, hemodynamic, biochemical, and magnetic resonance imaging
17. Evolution of brain infarction after transient focal cerebral ischemia in mice
18. Relationship between metabolic dysfunction, gene responses and delayed ischemic injury after middle cerebral ischemia in mice
19. Disturbances of cerebral protein synthesis and ischemic cell death
20. Stress-induced inhibition of protein synthesis initiation modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat
21. 2+ ATPases
22. Facilitated recovery from postischemic suppression of protein synthesis in the gerbil brain with ischemic tolerance
23. Resuscitation of the monkey brain after one hour complete ischemia: III. Indications of metabolic recovery
24. Calcium in ischemic cell death
25. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase. PERK
26. 2+ concentrations in the inhibition of mRNA translation
27. Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons
28. Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2 alpha, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells
29. Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia
30. Phosphorylation of eukaryotic elongation factor 2 in differentiating and proliferating HL-60 cells
31. Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil
32. Disturbances of the functioning of endoplasmic reticulum a key mechanism underlying neuronal cell injury?
33. Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin effect on protein synthesis
34. Effect of transient focal ischemia of mouse brain on energy state and NAD levels no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism
35. Phosphorylation of the eukaryotic initiation factor (eIF) 2α and inhibition of eIF-2B in GH3 pituary cells by perturbants of early protein processing that induce grp78
36. Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticulum calcium stores
37. p70, S6 kinase an enigma with variations
38. s6K
39. s6k by PDK1
40. Caspasemediated cleavage of eukaryotic translation initiation factor subunit 2 alpha
41. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
42. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus
43. Protective effect of hypothermia on hippocampal injury after 30 min forebrain ischemia in rats is mediated by postischemic recovery of protein synthesis
44. PKR; a sentinel kinase for cellular stress
45. Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein
46. Effect of barbiturate treatment on post-ischemic protein biosynthesis in gerbil brain